Abstract
At present, several teams of investigators have provided evidence that endogenous opiate peptides play an important role in interactions between the nervous, endocrine and immune systems, their dysfunctions being intimately associated with stress (Arrigo-Reina and Ferri, 1980). Hence, the rapid growth of psychoneuroimmunology, a new field of neurobiology, largely relies on investigation of opiatergic modulations of these systems. Non-opiate peptides, however, are equally involved in regulating the integrity of biochemical and physiological processes responsible for homeostasis.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Agarwal, R. A., Rastogi, R. B., and Singhal, R. L., 1976, Changes in brain catecholamines and spontaneous locomotor activity in response to thyrotropin releasing activity, Res. Comm. Chem. Pathol. Pharmacol., 15: 743–752.
Ashmarin, I. P., 1983, Neuropeptide complexes, in: Rational Search for New Neurotropic Agents, Zinâtne, Riga.
Ashmarin, I. P., Antonova, L. V., Burbaeva, G. Sh., and Kamensky, A. A., 1981, On the possibility of native ACTH4–10 being present in the rat, in: Abstr. 4th USSR Symp. on Drug Design, Riga.
Arrigo-Reina, R., and Ferri, S., 1980, Evidence of an involvement of the opioid peptidergic system in the reaction to stressful conditions, Eur. J. Pharmacol., 64: 885–888.
Berntson, G. G., and Berson, B. S., 1980, Antinociceptive effects of intraventricular or systemic administration of vasopressin in the rat, Life Sci., 26: 255–259.
Bhargava, H. N., 1982, Dissociation of tolerance to the analgesic and hypothermic effects of morphine using thyrotropin releasing hormone, Life Sci., 29: 1015–1020.
Block, L. H., Locher, R., and Tenschest, W., 1981, 125J-8-L-Arginine vasopressir, binding to human mononuclear phagocytes, J. Clin. Investig., 68: 374–381.
Bulaev, V. M., 1982, Opiate receptors and their ligands, in: Advances in Science and Technology, Series: Pharmacology. Chemotherapeutic Drugs. “Opioid Peptides and Their Receptors”, I. P. Ashmarin, Ed., Moscow.
Bukharin, O. V., Vasiliev, N. V., and Volodina, E. P., 1982, Oxytocin and vasopressin - regulators of immune homeostasis, in: Abstr. 3rd USSR Symp. on Regulation of Immune Homeostasis, Leningrad, 129–130.
Chipens, G., 1971, Similarity of signature carriers in some physiologically active peptides, in: Chemistry and Biology of Peptides, Zinâtne, Riga.
Chipens, G., Blüger, A., Wechsler, H., Timoshenko, Zh., Baumanis, E., Iriste, A., Daija, D., Mergina, G., Poluektova, L., Veretennikova, N., 1982, Comparative study of immunobiochemical effect of tuftsin and rigin, in: Abstr. USSR Symp. on Bioorganic Chemistry and Drug Design, Riga.
Chipens, G. I., Veretennikova, N. I., Zâlitis, G. M., Atare, Z. A., Afanasyeva, G. A., and Kukaine, E. M., 1980, New IgG fragments and their analogus possessing immunostimulating and immunoinhibitory activity, in: Abstr. 3rd Intern. Colloquium on Physico-Chemical Information Transfer of Reproduction and Ageing, Varna, Bulgaria, 22–23 Sept.:20.
De Wied, D., 1979, Pituitary and brain peptides and behaviour, in: Brain Peptides: a New Endocrinology, A. M. Gotto, ed., Elsevier/North Holland Biomed. Press, Amsterdam.
Deschodt-Lanckman, M., and Strosberg, A. D., 1983, In vitro degradation of the C-terminal octapeptide of cholecystokinin by enkephalinase, Febs Let., 152: 109–183.
DiAugustine, R. P., Lazarus, L. H., Jahnke, G., Khan. M. N., Erisman, M. D., and Linnoilar, R. I., 1980, Corticotropin/ß-endorphin immunoreactivity in rat mast cells. Peptide or protease? Life Sci., 27: 2663–2668.
Dolzhenko, A. T., and Komissarov, I. V., 1982, A comparative study of the modulating effect of thyroliberin and melanostatin on neuromediator release by rat brain slices, in: Abstr. USSR Symp. on Bioorganic Chemistry and Drug Design Riga.
Donoso, A. O., and Alvarez, E. O., 1984, Brain histamine as neuroendocrine transmitter, TIPS, March: 98–100.
Faith, R. E., Plotnikoff N. P., Murgo, A. J. (In press), Effects of opiates and enkephalins-endorphins on immune functions.
Feldberg, W., and Paton, W. D. M., 1949, Release of histamine by morphine alkaloids, J. Physiol. (Loud.), 111: 19P.
Greengard, P., 1979, Cyclic nucleotides, phosphorylated proteins, and the nervous system, Federat. Proc., 39: 2208–2217.
Haldar, J., Hofman, D. L., Nilaver, G., and Zimmerman, E. A., 1980, Oxytocin and vasopressin release by substance P injected into the cerebral ventricles of rats, in: Abstr. 9th Annu. Meet. Atlanta, Georgia, Nov. 2–6, 1979, Bethesda, Soc. Neurosci., 5: 447.
Henderson, N. D., 1970, Behavioural reactions of Wistar rats to conditioned fear stimuli, novelty and noxious stimulation, J. Psychol., 75: 19–34.
Johnson, H. M., 1983, Neuroendocrine polypeptide hormone regulation of lymphokine production and lymphocyte function, Lymphokine Research, 2: 49–56.
Johnson, H. M., Smith, E. M., Torres, B. A., and Blalock, J. E., 1982, Regulation of the in vitro antibody response by neuroendocrine hormones, Proc. Natl. Acad. Sci., 79 (13): 4171–4174.
Jörnvall, H.,Carlström, A.,Pettersson, T., Jacobsson, B., Persson, M., and Mutt, V., 1981, Structural homologies between prealbumin gastrointestinal prohormones and other proteins, Nature, 291: 261–263.
Kastin, A. J., Olson, R. D., Ehrensing, R. H., Berzas, M. C., Schally, A. V., and Coy, D. H., 1980, MIF-I differential actions as an opiate antagonists, Pharmacol. Biochem. Behay., 11: 721–723.
Kendler, K. S., Weitzman, R. E., and Fisher, D. A., 1978, The effect of pain on plasma arginine vasopressin concentration in man, Clin. Endocrinol., 8: 89–94.
Kluga, V., 1984, Peptides as Regulators of Brain Functions, Zinâtne, Riga.
Kluga, V., Abissova, N., Kukaine, E., Afanasyeva, G., Misiga, I., Myshliakova, N., Muceniece, R., and Svirskis, S., 1981a, Possible functional relationship between neuro-, immun-and glucomodulating peptides: A hypothesis, in: Abstr. 4th USSR Symp. on Drug Design, Riga.
Kluga, V., Abissova, N., Muceniece, R., Svirskis, S., Bienert, M., and Lipkowski, A., 1981b, Comparative study of substance P and its fragments: analgesic properties, effects on behaviour and monoaminergic processes, Byul. eksp. biol. i med., 12: 692–694.
Kluga, V., Muceniece, R., and Svirskis, S., 1982, Fragments of peptide hormones as possible central regulation factors, in: Neuropharmacology of Peptides, A. V. Waldman, Ed., Moscow.
Kluga, V., Praultte, G., Svirskis, S., Muceniece, R., Kukaine, E., and Abissova, N. A., 1984, Comparative study of the central effects of the immunopeptides tuftsin and rigin, LPSR Zin. Akad. véstis, 12: 103–109.
Kozlovskaya, M., Kluga, V., and Bondarenko, N., 1982, A comparison of psycho-tropic and neurochemical effects of short peptides, in: Neurochemical aspects of psychotropic action, A. V. Waldman, Ed., Moscow.
Kukaine, E., 1981, Effects of neuropeptides and neurotransmitters on the humoral immune system, in: Abstr. 4th USSR Symp. on Drug Design, Riga.
Kukaine, E., Muceniece, R., and Kluga, V., 1982, Comparison of neuro-and immunomodulating properties of low-molecular neuropeptides, Byul. eksp. biol. i med., 8: 79–82.
Kukaine, E., Rosenthal, G., and Kluga, V., 1984, Tuftsin and rigin–opiate or non-opiate peptides? in: Abstr. Conf. on Synthesis and Properties of Physiol. Active Agents, Vilnius, 70–71.
Lin, T. M., 1972, Gastrointestinal actions of the C-terminal tripeptide of gastrin, Gastroenterology, 63: 922–923.
Lolait, S. J., Lim, A. T. W., Toh, B. H., and Funder, J. M., 1984, Immunoreactive ß-endorphin in a subpopulation of mouse spleen macrophages, J. Clin. Invest., 73 (1): 277–280.
May, Ch. D., Lyman, M., Alberto, R., and Cheng, J., 1970, Procedures for immunochemical study of histamine release from leukocytes with small volume of blood, J. Allerg., 46: 12–20.
Miller, G. C., Murgo, A. J., and Plotnikoff, N. P., 1983, Enkephalins–enhancement of active T-cell rosettes from lymphoma patients, Clin. Immunol. Immunopathol., 26 (3): 446–451.
Najjar, V. A., and Nishioka, K., 1970, Tuftsin, a natural phagocytosis stimulatory peptide, Nature, 228: 672–673.
Nikitina, Z. S., Batuner, A. S., and Sytinsky, I. A., 1983, Activity of gamma-glutamine transferase in the brain following tuftsin administration, in: Abstr. 4th USSR Conf. on Biochemistry and Nervous System, Yerevan, 216–217.
Oehme, P., Bienert, M., Hecht, K. B., and Bergman, J., 1981, Substance P. Ausgewählte Probleme der Chemie, Biochemie, Pharmacologie, Physiologie und Pathophysiologie, Berlin.
Parviz, M. A., 1978, Psychopharmacology of morphinomimetic peptides in relation to schizophrenia, Gen. Pharmacol., 9: 221–222.
Porsolt, R. D., Bertin, A., and Jalfre, M., 1977, Behavioral despair in mice: a primary screening test for antidepressants, Arch. Intern. Pharmacodyn., 229: 327–336.
Rehfeld, J. F., and Golterman, N. R., 1979, Immunochemical evidence of cholecystokinin tetrapeptides in hog brain, J. Neurochemistry, 32: 1339–1341.
Ribeiro, S. A., Corrade, A. P., and Graff, F. G., 1968, Analgesia induced by intraventricular administration of bradykinin in the rabbit, Acta Physiol. Latinoam., 18: 78–81.
Rossie, S. S., and Miller, R. J., 1982, Regulation of mast cell histamine release by neurotensin, Life Sci., 31: 509–516.
Said, S. J., 1984, Vasoactive intestinal polypeptide (VIP): Current Status, Peptides, 5: 143–150.
Sewell, R. D. E., and Spencer, P. S. J., 1977, The role of biogenic agents in the actions of centrally-acting analgesics, in: Progress in Medicinal Chemistry, G. P. Ellis, G. B. West, Eds., Elsewier/North Holland Biomedical Press, Amsterdam.
Sofina, Z. P., Lagova, N. D., and Kalashnikova, N. M., 1982, Hypothalamic peptide factors as potential antitumour agents, in: Abstr. USSR Symp. on Bioorgan. Chemistry and Drug Design, Riga, 53.
Tagaki, H., Shiomi, H., Ueda, H., and Amano, H., 1979, A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser, Nature, 282: 410–413.
Vaught, J. C., Rothman, R. B., and Westfall, T. C., 1982, Mu and delta receptors: their role in analgesia and in differential effects of opioid peptides on analgesia, Life Sci., 30: 1443–1455.
Waksman, B. H., 1979, Adjuvants and immune regulation by lymphoid cells, Springer Seminar of Immunopathology, 2: 5–33.
Walaszek, E. J., 1970, Effect of bradykinin on the central nervous system, in: Handbook of Experimental Pharmacology, v. 25, Bradykinin, Kallidin and Kallikrein, E. G. Erdös, Ed., Springer Verlag, Berlin-Heidelberg-New York.
Waldman, A. W., 1982, Peptides as modulators of monoaminergic processes, in: Pharmacology of Neropeptides, A. V. Waldman, Ed., Moscow.
Weber, R., and Pert, C., 1984, Opiatergic modulation of the immune system, in: Central and Peripheral Endorphins: Basic and Clinical Aspects, E. E. Müller, A. R. Genazzani, Eds., Raven Press, New York.
Whitefield, J. F., Mac Manus, J. P., and Rixon, R. H., 1970, Potentiation by antidiuretic hormone (vasopressin) of the activity of parathyroid hormone to stimulate the proliferation of rat thymic lymphocytes, Hormone Metabol. Research, 2: 235–237.
Yamasaki, Y., Shimamura, O., Kizu, A., Nakagawa, M., and Ijichi, H., 1982, IgE-mediated 14C-serotonin release from rat mast cells modulated by morphine and endorphins, Life Sci., 31: 471–478.
Yoshinori, I., Kazunori, M., Yukihiro, A., Tetsuya, N., Michihiro, F., and Showa, U., 1983, Attact stress and IgE antibody production in rats, Pharmacol. Biochem. and Behay., 19: 883–886.
Zalitis, G., Afanasyeva, G., G., Golubeva, V., Veretennikova, N., and Chipens, 1981, Immunochemical properties of rigin and tuftsin and their effects on cellular and humoral immunity, in: Abstr. of USSR Symp. Bioorg. Chemistry and Drug Design, Riga, 49.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kluša, V. et al. (1986). Involvement of Non-Opiate Peptides in Psychoneuroimmunological Modulations. In: Plotnikoff, N.P., Faith, R.E., Murgo, A.J., Good, R.A. (eds) Enkephalins and Endorphins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0557-4_13
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0557-4_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0559-8
Online ISBN: 978-1-4899-0557-4
eBook Packages: Springer Book Archive