Prepubertal and Pubertal Endocrinology

  • Michael A. Preece


The processes of growth and development imply increases in cell size and number with all the accompanying requirements for protein and nucleic acid synthesis. For orderly growth, the availability of appropriate nutrients as the building blocks of macromolecular synthesis is fundamental. It has become clear over recent years that there is also a requirement for a network of supervising processes to control many or all of these metabolic steps. Most of the supervisory processes are controlled by the endocrine system. This network of interrelating hormones links the activity of the neuroendocrine system with cellular operations both in controlling relatively unchanging processes, which are little affected by the aging process, and in entraining processes that subserve changes and occur at specific times of life such as the development of puberty.


Growth Hormone Thyroid Hormone Luteinizing Hormone Pineal Gland Adrenal Androgen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Anderson, D. C., 1980, The adrenal androgen-stimulating hormone does not exist, Lancet 2: 454–456.CrossRefGoogle Scholar
  2. Apter, D., 1980, Serum steroids and pituitary hormones in female puberty: A partly longitudinal study, Clin. Endocrinol. 12: 107–120.CrossRefGoogle Scholar
  3. Apter, D., and Vihko, R., 1977, Serum pregnenolone, progesterone, 17-hydroxyprogesterone, testosterone and 5aipha-dihydrotestosterone during female puberty, J. Clin. Endocrinol. Metab. 45: 1039–1048.CrossRefGoogle Scholar
  4. Apter, D., Pakarinen, A., and Vihko, R., 1978a, Serum prolactin, FSH and LH during puberty in girls and boys, Acta Paediatr. Scand. 67: 417–423.CrossRefGoogle Scholar
  5. Apter, D., Viinikka, L., and Vihko, R., 1978b, Hormonal pattern of adolescent menstrual cycles, J. Clin. Endocrinol. Metab. 47: 944–954.CrossRefGoogle Scholar
  6. Apter, D., Pakarinen, A., and Hammond, G. L., et al.,1979, Adrenocortical function in puberty, Acta Paediatr. Scand. 68:599–604.Google Scholar
  7. Avruskin, T. W., Tang, S. C., Shenkman, L., Mitsuma, T., and Hollander, C. S., 1973, Serum triiodothyronine concentrations in infancy, childhood, adolescence and pediatric thyroid disorders, J. Clin. Endocrinol. Metab. 37: 235–237.CrossRefGoogle Scholar
  8. Boyer, R. M., Rosenfeld, R. S., Kapen, S., et al.,1974, Simultaneous augmented secretion of luteinising hormone and testosterone during sleep, J. Clin. Invest. 54:609–618.Google Scholar
  9. Boyar, R. M., Wu, R. H. K., Roffwatg, H., Kapen, S., Weitzman, E. D., Hellman, L., and Finkelstein, J. W., 1976, Human puberty-24 hour estradiol patterns in prepubertal girls, J. Clin. Endocrinol. Metab. 43: 1418–1421.CrossRefGoogle Scholar
  10. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., and Guillemin, R., 1973, Hypothalamic polypeptide that inhibits the secretion of immunocreactive pituitary growth hormone, Science 179: 77–79.CrossRefGoogle Scholar
  11. Costin, G., Kogut, M. D., Phillips, L. S., and Daughaday, W. H., 1976, Craniopharyngioma: The role of insulin in promoting post-operative growth, J. Clin. Endocrinol. Metab. 42: 370–379.CrossRefGoogle Scholar
  12. Curry, D. L., and Bennett, L. I., 1973, Dynamics of insulin release by perfused rat pancreases: Effect of hypophysectomy, growth hormone, adrenocorticotrophic hormone and hydrocortisone, Endocrinology 93: 602–609.CrossRefGoogle Scholar
  13. Ducharme, J. R., Forest, M. G., Peretti, E. de, Sempé, M., Collu, R., and Bertrand, J., 1976, Plasma adrenal and gonadal sex steroids in human pubertal development, J. Clin. Endocrinol. Metabl. 42: 468–476.CrossRefGoogle Scholar
  14. Faiman, C., and Winter, J. S. D., 1974, Gonadotrophins and sex hormone patterns in pubescence: Clinical data, in: Control of the Onset of Puberty (M. M. Grumbach, G. D. Grave, and F. E. Meyer, eds.), pp. 32–55, Wiley, New York.Google Scholar
  15. Finkelstein, J. W., Roffwarg, H. P., Boyar, R. M., ‘Cream, J., and Hellman, L., 1972, Age-related change in the 24-hour spontaneous secretion of growth hormone, J. Clin. Endocrinol. Metab. 35: 665–670.Google Scholar
  16. Fisher, D. A., Sack, J., Oddie, T. H., Pekary, A. E., Hershman, J. M., Lam, R. W., and Parslow, M. E., 1977, Serum T4, TBG, T3-uptake, reverse T3 and TSH concentrations in children 1–15 years of age, J. Clin. Endocrinol. 45: 191–198.CrossRefGoogle Scholar
  17. Forest, M. G., Peretti, E., de, and Bertrand, J., 1979, Developmental patterns of the plasma levels of testosterone, z4-androstenedione, 17-alphahydroxyprogesterone, dehydroepiandrosterone and its sulfate in normal infants and prepubertal children, in: The Endocrine Function of the Human Adrenal Cortex ( M. Serio, ed.), pp. 561–582, Academic Press, New York.Google Scholar
  18. Franchimont, P., Henderson, K., Verhoeven, G., HazeeHagelstein, M-T., Charlet-Renard, C., Demoulin, A., Bourguignon, J-P., and Lecomte-Yerna, M-J., 1981, Inhibin: Mechanisms of action and secretion, in: Intra-gonadal Regulation of Reproduction ( P. Franchimont and C. P. Channing, eds.), pp. 167–191, Academic Press, New York.Google Scholar
  19. Franks, S., 1983, Prolactin, in: Hormones in Blood 3rd ed. (C. H. Gray and V. H. T. James, eds.), Vol. IV, pp. 109–136, Academic Press, New York.Google Scholar
  20. Furlanetto, R. W., 1980, The somatomedin-C binding protein—Evidence for a heterologous subunit structure, Clin. Endocrinol. Metab. 51: 12–19.CrossRefGoogle Scholar
  21. Gallagher, T. F., Yoshida, K., Roffwarg, H. D., Fukushima, D. K., Weitzman, E. D., and Hellman, L., 1973, ACTH and cortisol secretory patterns in man, J. Clin. Endocrinol. Metab. 36: 1058–1068.CrossRefGoogle Scholar
  22. Gillies, G. E., and Lowry, P. J., 1982, in: Frontiers in Neuroendocrinology (W. F. Ganong and L. Martinit, eds.), Vol. 7 pp. 45–74, Raven Press, New York.Google Scholar
  23. Greenberg, A. H., Najjar, S., and Blizzard, R. M., 1974, Effects of thyroid hormone on growth, differentiation and development, in: Handbook of Physiology, Section 7: Endocrinology, Vol. 3: Thyroid ( M. A. Greer and D. H. Solomon, eds.), pp. 377–389, Williams and Wilkins, Baltimore.Google Scholar
  24. Grossman, A., Kruseman, A. C., Perry, L., Tomkin, S., Schally, A. V., Coy, D. H., Rees, L. H., ComaruSchally, A-M., and Besser, G. M., 1982, New hypothalamic hormone, corticotropin-releasing factor, specifically stimulates the release of adrenocorticotropic hormone and cortisol in man, Lancet 1: 921–922.CrossRefGoogle Scholar
  25. Gupta, D., McCafferty, E. M., and Rager, K., 1972, Plasma 5-alpha-dihydrotestosterone in adolescent males at different stages of sexual maturation, Steroids 19: 411–431.CrossRefGoogle Scholar
  26. Gupta, D., Attanasio, A., and Raaf, S., 1975, Plasma estrogen and androgen concentrations in children during adolescence, J. Clin. Endocrinol. Metab. 40: 636643.Google Scholar
  27. Hall, K., Sara, V. R., Enberg, G., and Ritzen, E. M., 1981, Somatomedins and postnatal growth, in: Biology of Normal Human Growth (M. Ritzen et al., eds.), pp. 275–283, Raven Press, New York.Google Scholar
  28. Ilondo, M. M., Vanderschueren-Lodeweyckx, M., Vlietinck, R., Pizarro, M., Malvaux, P., Aggermont, E., and Eeckels, R., 1982, Plasma androgens in children and adolescents, Horm. Res. 16: 61–77.CrossRefGoogle Scholar
  29. Ishimaru, T., Edmiston, W. A., Pages, L., and Horton, R., 1978, Splanchnic extraction and conversion of testosterone and dihydrotestosterone in Man, J. Clin. Endocrinol. Metab. 46: 528–533.CrossRefGoogle Scholar
  30. Kelch, R. P., Jenner, M. R., Weinstein, R., Kaplan, S. L., and Grumbach, M. M., 1972, Estradiol and testosterone secretion by human, simian and canine testes, in males with hypogonadism and in male pseudohermaphrodites with feminizing testis syndrome, J. Clin. Invest. 51: 824–830.CrossRefGoogle Scholar
  31. Klenar, C. J. H., and Brook, C. G. D., 1983, A mixed longitudinal study of adrenal steroid excretion in childhood and the mechanism of adrenarche, Clin. Endocrinol. 19: 117–129.CrossRefGoogle Scholar
  32. Kostyo, J. L., and Isaksson, O., 1977, Growth hormone and the regulation of somatic growth, Int. Rev. Physiol. 13: 255–274.Google Scholar
  33. Large, D. M., and Anderson, D. C., 1979, Twenty-four hour profiles of circulating androgens and oestrogens in male puberty with and without gynaecomastia, Clin, Endocrinol. 11: 505–521.Google Scholar
  34. Lee, P. A., Plotnick, L. P., Steele, R. E., Thompson, R. G., and Blizzard, R. M., 1976a, Integrated concentrations of luteinising hormone and puberty, J. Clin. Endocrinol. Metab. 43: 168–172.CrossRefGoogle Scholar
  35. Lee, P. A., Xenakis, T., Winer, J., 1976b, Puberty in girls: Correlation of serum levels of gonadotropins, prolactin, androgens, estrogens and progestins with physical changes, J. Clin. Endocrinol. Metab. 43: 775–784.CrossRefGoogle Scholar
  36. Lee, P. A., Plotnick, L. P., Migeon, C. J., and Kowarski, A. A., 1978, Integrated concentrations of follicle stimulating hormone and puberty, J. Clin. Endocrinol. Metab. 46: 488–490.CrossRefGoogle Scholar
  37. Lenko, H. L., Laing, U., Aubert, M. L., Paunier, L., and Sizonenko, P. C., 1981, Hormonal changes in puberty. VII. Lack of variation of daytime melatonin, J. Clin. Endocrinol. Metab. 54: 1056–1058.CrossRefGoogle Scholar
  38. Manchester, K. L., 1972, The effect of insulin on protein synthesis in diabetes, Diabetes 21: 447–452.Google Scholar
  39. Milman, A. E., de Moor, P., and Luckens, F. D. W., 1951, Relation of purified pituitary growth hormone and insulin in regulation of nitrogen balance, Am. J. Physiol. 166: 354–363.Google Scholar
  40. Nagarajan, L., and Anderson, W. B., 1982, Insulin promotes the growth of F9 embryonal carcinoma cells apparently by acting through its own receptor, Biochem. Biophys, Res. Commun. 106: 974–980.Google Scholar
  41. Pakarinen, A., Hammond, G. L., and Vihko, R., 1979, Serum pregnenolone, progesterone, 17 alpha-hydroxyprogesterone, androstenedione, testosterone, 5-alphadihydrotestosterone and androsterone during puberty in boys, Clin. Endocrinol. 11: 465–474.CrossRefGoogle Scholar
  42. Parker, L. N., and Odell, W. D., 1979, Evidence for existence of cortical-androgen stimulating hormone, Am. J. Physiol 236: 616–620.Google Scholar
  43. Parker, D. C., Jadd, H. J., Rossman, L. G., and Yen, S. S. C., 1975, Pubertal sleep-wake patterns of episodic LH, FSH and testosterone release in twin bodys, J. Clin. Endocrinol. Metab. 40: 1099–1109.CrossRefGoogle Scholar
  44. Parker, L. N., Lifrak, E. T., and Odell, W. D., 1983, A 60,000 moleculare weight human pituitary glycopeptide stimulates adrenal androgen secretion, Endocrinology 113: 2092–2096.CrossRefGoogle Scholar
  45. Parra, A., Villalpando, S., Junco, E., Urquieta, B., Ala-torre, S., and Garcia Bulnes, G., 1980, Thyroid gland function during childhood and adolescence, changes in serum TSH, T4, T3, thyroxine binding globulin, reverse T3 and free T4 and T3 concentrations, Acta Endocrinol. 93: 306–314.Google Scholar
  46. Prader, A., Tanner, J. M., and von Harnack, G. A., 1963, Catch-up growth following illness or starvation, J. Pediatr. 62: 646–659.CrossRefGoogle Scholar
  47. Preece, M. A., 1976, The effect of administered corticosteroids on the growth of children, Br. Postgrad. Med. J. 52: 625–630.CrossRefGoogle Scholar
  48. Preece, M. A., and Holder, A. T., 1982, The somatomedins: A family of serum growth factors, in: Recent Advances in Endocrinology and Metabolism ( J. L. H. O’-Riordan, ed.), Vol. 2, pp. 47–72, Churchill Livingstone, Edinburgh.Google Scholar
  49. Preece, M. A., Cameron, N., Baines Preece, J. C., and Sil-man, R., 1980, Auxological and serum hormonal changes during puberty, in: Pathophysiology of Puberty ( E. Cacciari and A. Prader, eds.), Vol. 36, pp. 79–88, Academic Press, London.Google Scholar
  50. Preece, M. A., Cameron, N., Donmall, M. C., Dunger, D. B., Holder, A. T., Baines Preece, J. C., Seth, J., Sharp, G. M., and Taylor, A. M., 1984, The endocrinology of male puberty, in: Proceedings of the IlIrd Congress of Auxology, Brussels, 1982 ( J. Bones, R. Hauspie, A, Sand, C. Susanne, and M. Hebbelinck, eds.), pp. 23–37, Plenum, New York.Google Scholar
  51. Radfar, N., Ansusingha K., and Kenny, F. M., 1976, Circulating bound and free estradiol and estrone during normal growth and development and in premature thelarche and isosexual precocity, J. Pediatr. 89: 719–723.CrossRefGoogle Scholar
  52. Rees, L. H., and Lowry, P. J., 1983, Adrenocorticotrophin and lipotrophin, in: Hormones in Blood, 3rd ed., ( C. H. Gray and V. H. T. James, eds.), Vol. IV, pp. 279–284, Academic Press, New York.Google Scholar
  53. Reiter, E. O., and Root, A. W., 1977, Effect of an infusion of Gn-RH upon levels of sex hormones in prepubertal and pubertal girls: Evidence for relative ovarian insensitivity, Steroids 30: 61–69.CrossRefGoogle Scholar
  54. Rich, B. H., Rosenfield, R. L., Lucky, A. W., Helke, J. C, and Otto, P., 1981, Adrenarche: changing adrenal response to adrenocorticotropin, J. Clin. Endocrinol. Metab. 52: 1129–1136.CrossRefGoogle Scholar
  55. Robbins, J., and Rall, J. E., 1983, The iodine containing hormones, in: Hormones in Blood, 3rd ed. ( C. H. Gray and V. H. T. James, eds.), Vol. IV, pp. 219–265, Academic Press, New York.Google Scholar
  56. Rosenfeld, R. I., Furlanetto, R., and Bock, D., 1983, Relationship of somatomedin-C concentrations to pubertal changes, J. Pediatr. 103: 723–728.CrossRefGoogle Scholar
  57. Sack, J., Bar-On, Z., Shemesh, J., and Becker, R., 1982, Serum T4, T3 and TBG concentrations during puberty in males, Eur. J. Pediatr. 138: 136–137.CrossRefGoogle Scholar
  58. Savage, D. C. L., Forsyth, C. C., McCafferty, E., and Cameron, J., 1975, The excretion of individual adrenocortical steroids during normal childhood and adolescence, Acta Endocrinol. (Kbh) 79: 551–567.Google Scholar
  59. Schally, A. V., Redding, T. W., Bowers, C. V., and Barrett, J. F., 1969, Isolation and properties of porcine thyrotropin-releasing hormone, J. Biol. Chem. 244: 4077–4088.Google Scholar
  60. Schally, A. V., Arimura, A., Baba, Y., Nair, R., Matsuo, H., Redding, T. W., Debeljuk, L., and White, W. F., 1971, Isolation and properties of the FSH and LH-releasing hormone, Biochem. Biophys. Res. Commun. 43: 393–399.CrossRefGoogle Scholar
  61. Schwartz, A. G., and Amos, H., 1968, Insulin dependence of cells in primary culture: Influence on ribosome integrity, Nature (London) 219: 1366–1367.CrossRefGoogle Scholar
  62. Silberman, H., 1983, Hormone and cartilage, in: Cartilage ( B. K. Hall, ed.), pp. 327–368. Academic Press, New York.Google Scholar
  63. Silman, R. E., Leone, R. M., Hooper, R. J. L., and Preece, M. A., 1979, Melatonin, the pineal gland and human puberty, Nature (London) 282: 301–302.CrossRefGoogle Scholar
  64. Sizonenko, P. C., Paunier, L., and Carmignac, D., 1976, Hormonal changes during puberty. IV: Longitudinal study of adrenal androgen secretions, Horm. Res. 7: 288–302.CrossRefGoogle Scholar
  65. Smith, S. R., Bledsoe, T., and Chhetri, M. K., 1975, Cortisol metabolism and the pituitary-adrenal axis in adults with protein-calorie malnutrition, J. Clin. Endocrinol. Metab. 40: 43–52.CrossRefGoogle Scholar
  66. Spiess, J., Rivier, J., Thorner, M., and Vale, W., 1982, Sequence analysis of a growth hormone releasing factor from a human pancreatic islet tumor, Biochemistry 21: 6037–6040.CrossRefGoogle Scholar
  67. Tanner, J. M., 1962, Growth at Adolescence, Blackwell, Oxford.Google Scholar
  68. Tanner, J. M., 1981, Endocrinology of puberty, in: Clinical Paediatric Endocrinology ( C. G. D. Brook, ed.), pp. 207–223, Blackwell, Oxford.Google Scholar
  69. Tanner, J. M., and Gupta, D., 1968, A longitudinal study of the excretion of individual steroids in children from 8 to 12 years, J. Endocrinol. 4: 139–156.CrossRefGoogle Scholar
  70. Tanner, J. M., Whitehouse, R. H., Jackson, D., and Gupta, D., 1978, A longitudinal study of 24-hour urinary excretion rates of LH, FSH, sex steroids, creati-nine and hydroxyproline throughout puberty, Proceedings of the 17th Annual Meeting of the European Society of Paediatric Endocrinology, Athens, 1978.Google Scholar
  71. Underwood, L. E., Smith, E. P., Van Wyk, J. J., Clemmons, D. R., D’Ercole, A. J., Pandian, M. R., Preece, M. A., and Moore, W. V., 1986, Somatomedin-C/insulin-like Growth factor I: Regulation and clinical applications, in: Human Growth Hormone (S. Raiti, ed.), Plenum Press, New York (in press).Google Scholar
  72. Waldhauser, F., and Wurtman, R. J., 1983, The secretion and actions of melatonin, in: Biochemical Actions of Hormones ( G. Litwack, ed.), pp. 187–225, Academic Press, New York.Google Scholar
  73. Waldhauser, F., Weiszenbacher, G., Frisch, H., Zeitalhuber, U., Waldhauser, N., and Wurtman, R. J., 1984, Fall in nocturnal serum melatonin during prepuberty and pubescence, Lancet 1: 362–365.CrossRefGoogle Scholar
  74. Winter, J. S. D., and Faiman, C., 1973, The development of cyclic pituitary gonadal function in adolescent females, J. Clin. Endocrinol. Metab. 37: 714–718.CrossRefGoogle Scholar
  75. Wurtman, R. J., Axelrod, J., and Chu, E. W., 1963, Melatonin, a pineal substance: Effect on the rat ovary, Science 141: 277–278.CrossRefGoogle Scholar
  76. Zumoff, B., Fukushima, D. K., Weitzman, E. D., Kream, J., and Hellman, L., 1974, The sex difference in plasma cortisol concentration in man, J. Clin. Endocrinol. Metab. 39: 805–808.CrossRefGoogle Scholar
  77. Zumoff, B., Bradlow, H. L., Finkelstein, J., Boyar, R. M., and Hellamn, L., 1976, The influence of age and sex on the matabolism of testosterone, J. Clin. Endocrinol. Metab. 42: 703–706.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Michael A. Preece
    • 1
  1. 1.Department of Growth and Development, Institute of Child HealthUniversity of LondonLondonEngland

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