Synthesis and Biological Activities of Endo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalimide and Its Polymers
The high molecular weight antitumor compounds(HMAC) are attracting much interest from the standpoints of polymers synthesis as well as drug development, because of their high specificity of action, low toxic side effects and longer duration of drug action as compared with low molecular weight antitumor compounds(LMAC).1–9 HMAC may be combined with large molecules in the living body and be slowly released into the biological fluids, giving effective concentrations over long periods.
KeywordsAntitumor Activity Maleic Anhydride Cytotoxicity Test Methine Proton Cyclic Ether
Unable to display preview. Download preview PDF.
- 3.M. Akashi, K. Beppu, I. Kikuchi and N. Mizauchi, J. Mcromol. Sci-Chem. ED.,17, 351 (1986).Google Scholar
- 4.R. M. Ottenbrite, J. Mcrowol. Sci. chem., A22(57), 819(1985).Google Scholar
- 5.T. Oucin, H. Juzei, Y. Sakamoto, H. Chikachita and O. Vogl, J.Polym.Sci.,Polym.Chem. Vol.23, 2059(1986).Google Scholar
- 10.J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, Proc. 3rd Pacific Polymer Conf., Gold Coast, Australia, Dec.13–17,pp.75–76(1993).Google Scholar
- 11.D. Y. Lee, N. J. Lee, J. G. Jeong, C. S. Ha and W. J. Cho, The Society of Polymer Science, Japan, 797 Chapaffil l0/12–10/14.(1994).Google Scholar
- 12.G. T. Gam, J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, J.Appl.Polym.Sci. in print(1995).Google Scholar
- 13.G. T. Gam, J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, IUPAC International Symposium on Functional and High Performance Polymers, Taipei, Taiwan, Nov. 14–16,p.(1994).Google Scholar