Synthesis and Biological Activities of Endo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalimide and Its Polymers

  • Gi Cheol Kim
  • Jin Gon Jeong
  • Neung Ju Lee
  • Chang Sik Ha
  • Won Jei Cho


The high molecular weight antitumor compounds(HMAC) are attracting much interest from the standpoints of polymers synthesis as well as drug development, because of their high specificity of action, low toxic side effects and longer duration of drug action as compared with low molecular weight antitumor compounds(LMAC).1–9 HMAC may be combined with large molecules in the living body and be slowly released into the biological fluids, giving effective concentrations over long periods.


Antitumor Activity Maleic Anhydride Cytotoxicity Test Methine Proton Cyclic Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. Ozaki, Y. Ike, H. Mizuno, K. Ishikawa and H. Mon, Bull.Chem.Soc.Japan, 50, 2406 (1977).CrossRefGoogle Scholar
  2. 2.
    P. P. Umrigar, S. Ohashi and G. B. Butler, J.Polym.Sci.,Polym.Chem.Ed., 17, 351 (1919).CrossRefGoogle Scholar
  3. 3.
    M. Akashi, K. Beppu, I. Kikuchi and N. Mizauchi, J. Mcromol. Sci-Chem. ED.,17, 351 (1986).Google Scholar
  4. 4.
    R. M. Ottenbrite, J. Mcrowol. Sci. chem., A22(57), 819(1985).Google Scholar
  5. 5.
    T. Oucin, H. Juzei, Y. Sakamoto, H. Chikachita and O. Vogl, J.Polym.Sci.,Polym.Chem. Vol.23, 2059(1986).Google Scholar
  6. 6.
    R. M. Ottenbrite, J. Sunamoto, T. Sato, K. Kojima, K. Sahara, K. Hara, M. Oka, J. Bioact & Compati. Polym. 3, 184,(1988).CrossRefGoogle Scholar
  7. 7.
    G. Butler, J. Macromol Sci-Chem., A13(3), 351 (1979).CrossRefGoogle Scholar
  8. 8.
    N. J. Lee, C. S. Ha, and W. J. Cho, J.Macromol.Sci-Chem., 29, 2, 161(1992).CrossRefGoogle Scholar
  9. 9.
    N. J. Lee, C. S. Ha, and W. J. Cho, Bioact.& Compati.Polym. 7, 39(1992).CrossRefGoogle Scholar
  10. 10.
    J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, Proc. 3rd Pacific Polymer Conf., Gold Coast, Australia, Dec.13–17,pp.75–76(1993).Google Scholar
  11. 11.
    D. Y. Lee, N. J. Lee, J. G. Jeong, C. S. Ha and W. J. Cho, The Society of Polymer Science, Japan, 797 Chapaffil l0/12–10/14.(1994).Google Scholar
  12. 12.
    G. T. Gam, J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, J.Appl.Polym.Sci. in print(1995).Google Scholar
  13. 13.
    G. T. Gam, J. G. Jeong, N. J. Lee, C. S. Ha and W. J. Cho, IUPAC International Symposium on Functional and High Performance Polymers, Taipei, Taiwan, Nov. 14–16,p.(1994).Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Gi Cheol Kim
    • 1
  • Jin Gon Jeong
    • 1
  • Neung Ju Lee
    • 2
  • Chang Sik Ha
    • 1
  • Won Jei Cho
    • 1
  1. 1.Department of Polymer Science and EngineeringPusan National UniversityPusanKorea
  2. 2.Department of Premedical SciencesKosin UniversityPusanKorea

Personalised recommendations