Pharmacological Agents and the Release of Arachidonic Acid and Prostaglandin Biosynthesis by Rabbit Iris Muscle

  • Ata A. Abdel-Latif
  • Shokofeh Naderi
  • Sardar Y. K. Yousufzai
Part of the FIDIA Research Series book series (FIDIA, volume 4)


Arachidonic acid (AA), the precursor of prostaglandins (PGs) and other biological active substances, is found mainly esterified to membrane phospholipids, almost exclusively in the 2-acyl position, from which it could be released by the action of lipases (Lands and Samuelson, 1968; Vogt, 1978) and reincorporated by a deacylation-reacylation cycle (for reviews see Hill and Lands, 1970; Holub and Kuksis, 1978; Irvine, 1982).


Arachidonic Acid Arachidonic Acid Release Myoinositol Phosphate Rabbit Iris Iris Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





platelets-activating factor




1, 2-diacylglycerol


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abdel-Latif AA, Akhtar RA and Hawthorne JN (1977) Biochem J 162: 61–73.PubMedGoogle Scholar
  2. Abdel-Latif AA, Luke B and Smith JP (1980) Biochim Biophys Acta 614: 425–434.PubMedCrossRefGoogle Scholar
  3. Abdel-Latif AA and Smith JP (1982) Biochim Biophys Acta 711: 478–489.PubMedCrossRefGoogle Scholar
  4. Abdel-Latif AA and Smith JP (1984) Can J Biochem Cell Biol 62: 170–177.PubMedCrossRefGoogle Scholar
  5. Abdel-Latif AA, Smith JP and Dover RK (1983a) Biochem Pharmacol 32: 729–732.PubMedCrossRefGoogle Scholar
  6. Abdel-Latif AA, Smith JP, Yousufzai SYK and Dover RK (1983b) In: Sun GY, Bazan N, Wu J-Y, Porcellati G and Sun AY (eds): Neural Membranes. The Humana Press, Clifton, New Jersey pp 97–122.CrossRefGoogle Scholar
  7. Abdel-Latif AA, Smith JP and Akhtar RA (1985) In: Bleasdale JE, Eichberg J and Hauser G (eds): Inosital and phosphoinositides: Metabolism and Regulation. The Humana Press, Clifton, New Jersey, pp. 275–298.CrossRefGoogle Scholar
  8. Akhtar RA and Abdel-Latif AA (1978) Biochim Biophys Acta 527: 159–170.PubMedCrossRefGoogle Scholar
  9. Akhtar RA and Abdel-Latif AA (1980) Biochem J 192: 783–791.PubMedGoogle Scholar
  10. Akhtar RA and Abdel-Latif AA (1984) Biochem J 224: 291–300.PubMedGoogle Scholar
  11. Akhtar RA, Taft WC and Abdel-Latif AA (1983) J Neurochem 41: 1460–1468.PubMedCrossRefGoogle Scholar
  12. Bell RL, Kennedy DA, Stanford N and Majerus PW (1979) Proc Natl Acad Sci USA 76: 3238–3241.PubMedCrossRefGoogle Scholar
  13. Billah MM and Lapetina EG (1982) J Biol Chem 257: 5196–5200.PubMedGoogle Scholar
  14. Findley SR, Lichtenstein LM, Hanahan DJ and Pinckard RN (1981) Am J Physiol 241: C130–134.Google Scholar
  15. Flower RJ and Blackwell GJ (1979) Nature (London) 278: 456–459.CrossRefGoogle Scholar
  16. Hill EE and Lands WEM (1970) In: Wakil SJ (ed): Lipid Metabolism. Academic Press New York pp. 185–279.CrossRefGoogle Scholar
  17. Holub BJ and Kuksis A (1978) Adv Lipid Res 16: 1–125.PubMedGoogle Scholar
  18. Ieyasu H, Takai Y, Kaibuchi K, Sawamura M and Nishizuka Y (1982) Biochem Biophys Res Commun 108: 1701–1708.PubMedCrossRefGoogle Scholar
  19. Irvine RF (1982) Biochem J 204: 3–16.PubMedGoogle Scholar
  20. Kloprogge E and Akkerman JWN (1984) Biochem J 223: 901–909.PubMedGoogle Scholar
  21. Lands WEM and Samuelsson B (1968) Biochim Biophys Acta 164: 426–429.PubMedCrossRefGoogle Scholar
  22. Lee TC, Malone B, Blank ML and Snyder F (1981) Biochem Biophys Res Commun 102: 1262–1268.PubMedCrossRefGoogle Scholar
  23. MacIntyre DE and Pollock WK (1983) Biochem J 212: 433–437.PubMedGoogle Scholar
  24. Mauco G, Chap H and Douste-Blazy L (1983) FEBS Lett 153: 361–365.PubMedCrossRefGoogle Scholar
  25. McKean ML, Smith JB and Silver MJ (1981) J Biol Chem 256: 1522–1524.PubMedGoogle Scholar
  26. Okazaki T, Sagawa N, Okita JR, Bleasdale JE, MacDonald PC and Johnston JM (1981) J Biol Chem 256: 7316–7321.PubMedGoogle Scholar
  27. Pinckard RN, McManus LM and Hanahan DJ (1982) Adv Inflam Res 4: 147–180.Google Scholar
  28. Shaw JO, Klusick SJ and Hanahan DJ (1981) Biochim Biophys Acta 663: 222–229.PubMedCrossRefGoogle Scholar
  29. Shukla SD and Hanahan DJ (1982) Biochem Biophys Res Commun 106: 697–703.PubMedCrossRefGoogle Scholar
  30. Vargaftig BB, Chignard M, Benveniste J, Lefort J and Wal F (1981) Ann NY Acad Sci 370: 119–137.PubMedCrossRefGoogle Scholar
  31. Vogt W (1978) Adv Prostaglandin and Thromboxane Res 3: 89–95.Google Scholar
  32. Walsh CE, Waite BM, Thomas MJ and DeChatlet LR (1981) J Biol Chem 256: 7228–7234.PubMedGoogle Scholar
  33. Yousufzai SYK and Abdel-Latif AA (1983) Exp Eye Res 37: 279–292.PubMedCrossRefGoogle Scholar
  34. Yousufzai SYK and Abdel-Latif AA (1984) Prostaglandins 28: 399–415.PubMedCrossRefGoogle Scholar
  35. Yousufzai SYK and Abdel-Latif AA (1985a) Biochem Pharmacol 34: 539–544.PubMedCrossRefGoogle Scholar
  36. Yousufzai SYK and Abdel-Latif AA (1985b) Biochem J 228: 697–706.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Ata A. Abdel-Latif
    • 1
  • Shokofeh Naderi
    • 1
  • Sardar Y. K. Yousufzai
    • 1
  1. 1.Department of Cell and Molecular BiologyMedical College of GeorgiaAugustaUSA

Personalised recommendations