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Phospholipid Research and the Nervous System pp 57–66Cite as

Drugs Affecting Membrane Lipid Catabolism: The Brain Free Fatty Acid Effect

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Part of the book series: FIDIA Research Series ((FIDIA,volume 4))

Abstract

In the past 15 years, the brain “free fatty acid effect” has become a well-recognized phenomenon, elicited by a variety of stimuli, including: electroconvulsive shock (ECS) (Bazan 1970; Bazan and Rakowski, 1970; Aveldano and Bazan, 1979), drug-induced convulsions (Bazan, 1971; Marion and Wolfe, 1978; Siesjö et al., 1982; Rodriguez de Turco et al., 1983), anoxia and ischemia (Bazan, 1970; Cenedella et al., 1975; Aveldano and Bazan, 1975a; Rehncrona et al., 1982; Shiu et al., 1983; Yoshida et al., 1983), and cryogenic brain injury (Chan et al., 1983; Bazan et al., 1984). An increase in membrane phospholipid catabolism is the earliest response to brain injuries (Bazan, 1976). Furthermore, diacylglycerols (DAG) are simultaneously accumulated during ischemia (Aveldano and Bazan, 1975b) and convulsions (Rodriguez de Turco et al., 1983). The largest contribution to increases in both free fatty acids (FFA) and DAG is the accumulation of stearic (18:0) and arachidonic (20:4) acids. Based upon this observation, it has been suggested that the breakdown of phospholipids enriched in these fatty acids (i. e. inositol lipids) is involved (Aveldano and Bazan, 1975b).

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Abbreviations

FFA:

free fatty acids

ECS:

electroconvulsive shock

20:4:

arachidonic acid

18:0:

stearic acid

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Author information

Author notes

  1. Elena B. Rodriguez de Turco

    Present address: Department of Physiology, Louisiana State University Medical Center, 1901 Perdido Street, New Orleans, LA, 70112-3098, USA

Authors and Affiliations

  1. Instituto de Investigaciones Bioquimicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad Nacional del Sur (INIBIBB), Bahia Bianca, Argentina

    Elena B. Rodriguez de Turco

Authors
  1. Elena B. Rodriguez de Turco
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Editor information

Editors and Affiliations

  1. Department of Physiological Chemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks

  2. Centre de Neurochimie du CNRS, Strasbourg, France

    Louis Freysz

  3. Fidia Research Laboratories, Abano Terme, Italy

    Gino Toffano

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© 1986 Springer-Verlag Berlin Heidelberg

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Rodriguez de Turco, E.B. (1986). Drugs Affecting Membrane Lipid Catabolism: The Brain Free Fatty Acid Effect. In: Horrocks, L.A., Freysz, L., Toffano, G. (eds) Phospholipid Research and the Nervous System. FIDIA Research Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-0490-4_7

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  • DOI: https://doi.org/10.1007/978-1-4899-0490-4_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-0492-8

  • Online ISBN: 978-1-4899-0490-4

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