Drugs Affecting Membrane Lipid Catabolism: The Brain Free Fatty Acid Effect

  • Elena B. Rodriguez de Turco
Part of the FIDIA Research Series book series (FIDIA, volume 4)


In the past 15 years, the brain “free fatty acid effect” has become a well-recognized phenomenon, elicited by a variety of stimuli, including: electroconvulsive shock (ECS) (Bazan 1970; Bazan and Rakowski, 1970; Aveldano and Bazan, 1979), drug-induced convulsions (Bazan, 1971; Marion and Wolfe, 1978; Siesjö et al., 1982; Rodriguez de Turco et al., 1983), anoxia and ischemia (Bazan, 1970; Cenedella et al., 1975; Aveldano and Bazan, 1975a; Rehncrona et al., 1982; Shiu et al., 1983; Yoshida et al., 1983), and cryogenic brain injury (Chan et al., 1983; Bazan et al., 1984). An increase in membrane phospholipid catabolism is the earliest response to brain injuries (Bazan, 1976). Furthermore, diacylglycerols (DAG) are simultaneously accumulated during ischemia (Aveldano and Bazan, 1975b) and convulsions (Rodriguez de Turco et al., 1983). The largest contribution to increases in both free fatty acids (FFA) and DAG is the accumulation of stearic (18:0) and arachidonic (20:4) acids. Based upon this observation, it has been suggested that the breakdown of phospholipids enriched in these fatty acids (i. e. inositol lipids) is involved (Aveldano and Bazan, 1975b).


Free Fatty Acid Arachidonic Acid Electroconvulsive Shock Muscarinic Cholinergic Receptor Free Fatty Acid Release 
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free fatty acids


electroconvulsive shock


arachidonic acid


stearic acid


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Elena B. Rodriguez de Turco
    • 1
  1. 1.Instituto de Investigaciones Bioquimicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)Universidad Nacional del Sur (INIBIBB)Bahia BiancaArgentina

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