Possible Glial Modulation of Neuronal Activity by Eicosanoids and Phosphoinositide Metabolites
Metabolites of phosphoinositides and of arachidonic acid (AA) may serve central roles as intermediates in signal transmission and regulation of cellular processes. Our understanding of the pathways for the generation of these metabolites and of their biological role is primarily derived from studies in non-neural tissues. An especially detailed body of knowledge has been accumulated concerning their role in the communication between platelets and vascular endothelial cells during platelet activation (Lapetina, 1983; Rittenhouse-Simmons, 1984; Nishizuka, 1984; Zucker and Nacmias, 1985). Similar metabolic pathways are activated in neural tissue in response to a variety of stimuli (for review see: Wolf, 1982; Berridge et al., 1984).
KeywordsArachidonic Acid Metabolism Arachidonic Acid Metabolite Inositol Trisphosphate C62B Cell Inositol Phospholipid
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