Possible Glial Modulation of Neuronal Activity by Eicosanoids and Phosphoinositide Metabolites

  • J. J. DeGeorge
  • P. Morell
  • E. G. Lapetina
Part of the FIDIA Research Series book series (FIDIA, volume 4)


Metabolites of phosphoinositides and of arachidonic acid (AA) may serve central roles as intermediates in signal transmission and regulation of cellular processes. Our understanding of the pathways for the generation of these metabolites and of their biological role is primarily derived from studies in non-neural tissues. An especially detailed body of knowledge has been accumulated concerning their role in the communication between platelets and vascular endothelial cells during platelet activation (Lapetina, 1983; Rittenhouse-Simmons, 1984; Nishizuka, 1984; Zucker and Nacmias, 1985). Similar metabolic pathways are activated in neural tissue in response to a variety of stimuli (for review see: Wolf, 1982; Berridge et al., 1984).


Arachidonic Acid Metabolism Arachidonic Acid Metabolite Inositol Trisphosphate C62B Cell Inositol Phospholipid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. J. DeGeorge
    • 1
  • P. Morell
    • 1
  • E. G. Lapetina
    • 1
    • 2
  1. 1.Biology Science Research Center, Department of Biochemistry and NutritionUniversity of North CarolinaChapel HillUSA
  2. 2.Department of Molecular BiologyThe Wellcome Research LaboratoriesResearch Triangle ParkUSA

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