Axonally Transported Phospholipids and Neurite Regrowth
The growing body of knowledge concerning the axonal transport of neuronal intracellular components is very impressive today even if restricted to the multidisciplinary achievements obtained in investigating the phospholipid transport alone. Despite the large number of investigators who have sought to determine, at a molecular level, the dynamics of phospholipid transport and a great variety of substances and organelles in both directions, we do not actually have a clear idea of the mechanism underlying this process. However, recent work from many laboratories, addressed towards the understanding of how normal cells function in delivering substances to the periphery, is promising in this regard. Interestingly, the recognition of the features of intracellular transport in axotomized neurons capable of regeneration paves the way to a tighter linkage of innovative research between basic neuroscience and clinical concern.
KeywordsSciatic Nerve Axonal Transport Ventral Horn Hypoglossal Nerve Acyltransferase Activity
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