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Essential Fatty Acids and Phospholipids as Drugs in the Treatment of Alcoholism

  • John Rotrosen
  • David J. Segarnick
  • Adam Wolkin
Conference paper
Part of the FIDIA Research Series book series (FIDIA, volume 4)

Abstract

This chapter will focus on the potential use of lipids and phospholipids as therapeutic agents in treating alcoholism, and on behavioral, biochemical and physiological interactions between alcohol, essential fatty acids, and prostaglandins. The rationale for these approaches is based on alcohol’s effects on membrane fluidity, lipid metabolism, and prostaglandin synthesis.

Keywords

Essential Fatty Acid Chloral Hydrate Alcohol Withdrawal Fetal Alcohol Syndrome Alcohol Withdrawal Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anton RF, Randall CL, Wallis CJ (1983) Effect of acute ethanol exposure on in vivo brain cortical PGE levels in C3H mice. Alcoholism 7: 104.Google Scholar
  2. Bruni A and Toffano G (1982) Lysophosphatidylserine, a short-lived intermediate with plasma membrane regulatory properties. Pharmacol Res Commun 14: 469–482.PubMedCrossRefGoogle Scholar
  3. Cicero T (1978) Tolerance to and physical dependence on alcohol: behavioral and neurobiochemical mechanisms. In: Lipton MA, DiMascio A and Killam KF (eds): Psychopharmacology: A Generation of Progress. Raven Press, New York, pp. 1603–1615.Google Scholar
  4. Crawford MA (1983) Background to essential fatty acids and their prostanoid derivatives, Br J Pharmacol 58: 9–16.Google Scholar
  5. Ellingboe J (1978) Effects of alcohol on neurochemical processes. In: Lipton MA, DiMascio A and Killam KF (eds): Psychopharmacology: A Generation of Progress. Raven Press, New York, pp. 1653–1664.Google Scholar
  6. George FR and Collins AC (1985) EthanoFs behavioral effects may be partly due to increases in brain prostaglandin production. Alcoholism, Clin Exp Res 9: 143–146.CrossRefGoogle Scholar
  7. George FR, Jackson SJ, Collins AC (1981) Prostaglandin synthesis inhibitors antagonize hypothermia induced by sedative hypnotics. Psychopharmacology 74: 241–244.PubMedCrossRefGoogle Scholar
  8. George FR, Elemer GI, Collins AC (1982) Indomethacin significantly reduces mortality due to acute ethanol exposure. Substance and Alcohol Actions/Misuse 3: 267–274.PubMedGoogle Scholar
  9. Glen I (1984) Possible pharmacologic approaches to the prevention and treatment of alcohol related CNS impairment: results of a double blind trial of essential fatty acids. In: Edwards G and Littleton J (eds): Pharmacological Treatments for Alcoholism. Crooms-Helm, London, pp. 331–345.Google Scholar
  10. Goheen SC, Larkin EC, Ananda Rao G (1983) Severe fatty liver in rats fed a fat-free ethanol diet and its prevention by small amounts of dietary arachidonate. Lipids 18: 285–289.PubMedCrossRefGoogle Scholar
  11. Hill M and Bangham AD (1975) General depressant drug therapy: a biophysical aspect. Adv Exp Med Biol 59: 1–10.PubMedGoogle Scholar
  12. Karpe F, Neri A, Ånggård E (1983) The effect of dietary primrose oil on ethanol withdrawal in the rat. Acta Pharmacol Toxicol 53: 18P.Google Scholar
  13. Littleton JM and John GR (1977) Synaptosomal membrane lipids of mice during continuous exposure to ethanol. J Pharm Pharmacol 29: 579–580.PubMedCrossRefGoogle Scholar
  14. Manku MS, Oka M, Horrobin DF (1979) Differential regulation of the formation of prostaglan-dins and related substances from arachidonic acid and dihomogammalinolenic acid. I. Effects of ethanol. Prostaglandins Med 3: 119–128.PubMedCrossRefGoogle Scholar
  15. Nervi AM, Peluffo RD, Brenner RR, Leikin AI (1980) Effect of ethanol administration on fatty acid desaturation. Lipids 15: 263–268.PubMedCrossRefGoogle Scholar
  16. Randall CL and Anton RF: Aspirin reduces alcohol-induced prenatal mortality and malformations in mice, submitted for publication.Google Scholar
  17. Reitz RC (1980) The effects of ethanol administration on lipid metabolism. Lipids 15: 263–268.CrossRefGoogle Scholar
  18. Ritz MC, George FR, Collins AC (1981) Indomethacin antagonizes ethanol-induced but not pentobarbitol-induced behavioral activation. Substance and Alcohol Actions/Misuse 2: 289–299.Google Scholar
  19. Rotrosen J, Mandio D, Segarnick D, Traficante LJ, Gershon S (1980) Ethanol and prostaglandin E1: biochemical and behavioral interactions. Life Sciences 26: 1867–1876.PubMedCrossRefGoogle Scholar
  20. Segarnick DJ, Rjer H, Rotrosen J (1985a) Precursor-and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. Biochem Pharmacol 34: 1343–1346.PubMedCrossRefGoogle Scholar
  21. Segarnick DJ, Mandio Cordasco D, Rotrosen J (1985b) Prostanoid modulation (mediation?) of certain behavioral effects of ethanol. Pharmacol Biochem Behav, 23:71–75.PubMedCrossRefGoogle Scholar
  22. Segarnick DJ, Mandio Cordasco D, Agura V, Cooper NS, Rotrosen J (1985c) Gamma linolenic acid inhibits the development of the ethanol-induced fatty liver. Prostaglandins Leukotrienes Med 17: 277–282.CrossRefGoogle Scholar
  23. Segarnick DJ, Wolkin A, Rotrosen J (1986) Biochemical, behavioral and clinical interactions between essential fatty acids, prostaglandins and ethanol. Advances in Lipid Research, in press.Google Scholar
  24. Wilson DE, Engel J and Wong R (1973) Prostaglandin E1 prevents alcohol-induced fatty liver. Clinical Research 21:829.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • John Rotrosen
    • 1
  • David J. Segarnick
    • 1
  • Adam Wolkin
    • 1
  1. 1.Department of Psychiatry, New York Veterans Administration Medical CenterNew York University School of Medicine and Psychiatry ServiceNew YorkUSA

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