Phospholipid Metabolism in Aging Brain
The problem of aging may be considered from different points of view. Based on the main tendencies in the theoretical approach to aging, such points can be summarized as follows: a) predetermination (genetical?) of the maximal extent of life; b) result of random negative influences upon cells (Hocman, 1979). However, leaving aside the theoretical approach to the problem, valuable insight may be gained by studying the variety of metabolic changes during aging even though in these types of studies it is difficult to determine the causes and effects. Nevertheless, it is known that some biological functions are strictly connected with the membrane and that each modification of them may influence cellular functions. On this basis, we have studied some aspects of the metabolism of phospholipids in the brain, as these compounds influence the membrane status. In particular, we have determined the rate of the main phospholipid biosynthesis and turnover in aged rat brain with the final target of trying to connect some alterations of physiological functions to the variations of this metabolism. The knowledge of these metabolic changes connected with aging may also be useful for a pharmacological approach to the problem.
KeywordsArachidonic Acid Aged Brain Phospholipid Metabolism Phospholipid Molecule Phospholipid Biosynthesis
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