Effects of Ethanol on Brain Phospholipids
The primary mode of action of ethanol is on the neural membranes. While excessive intake can result in acute intoxication, development of tolerance and physical dependence is frequently associated with long term intake. On withdrawal of the drug, the behavioral manifestation of hyperexcitability is shown in man, as well as in animal models. In spite of the behavioral and physiological effects known to be associated with alcoholism, the molecular site of ethanol action in the central nervous system has not been clearly elucidated.
KeywordsChronic Ethanol Brain Membrane Acidic Phospholipid Synaptic Plasma Membrane Brain Phospholipid
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