The Effects of Ethanol on Receptor Activated Phospholipid Cascades

  • Fulton T. Crews
  • Cynthia Theiss
  • Robert Raulli
  • Rueben A. Gonzales
Part of the FIDIA Research Series book series (FIDIA, volume 4)


Ethanol is one of the most widely used drugs in the world. The resulting alcohol abuse and alcoholism is a major health and social problem. An understanding of the actions of ethanol are fundamental to a rational approach to treating alcoholism and to reversing the pathology associated with excessive ethanol consumption.


Calcium Influx Guanine Nucleotide Calcium Ionophore Guanine Nucleotide Binding Protein Phosphoinositide Hydrolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berridge MJ (1984) Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 220: 345–360.PubMedGoogle Scholar
  2. Chin JH and Goldstein DB (1981) Membrane-disordering action of ethanol: Variation with membrane cholesterol content and depth of the spin-label probe. Mol Pharmacol 19: 425–431.PubMedGoogle Scholar
  3. Crews FT (1982) Rapid changes in phospholipid metabolism during secretion and receptor activation. Int Rev Neurobiol 23: 141–163.PubMedCrossRefGoogle Scholar
  4. Crews FT and Gonzales R (1985) Correlation of ethano’s membrane action and inhibition of receptor stimulated release from rat mast cells. J Pharmacol Exp Therap, in press.Google Scholar
  5. Crews FT and Heiman AS (1985) Interaction of phospholipid methylation and phosphatidylinositol metabolism in stimulation of secretion. Phospholipids in the Nervous System 2: 87–98.Google Scholar
  6. Crews FT, Majchrowitz E and Meeks R (1983) Changes in cerebral cortical synaptosomal membrane fluidity and composition in ethanol dependent rats. Psychopharmacology 81: 208–213.PubMedCrossRefGoogle Scholar
  7. Emilsson A and Sundler R (1984) Differential activation of phosphatidylinositol deacylation via diphosphoinositide in macrophages responding to zymosan and ionophore A23187. J Biol Chem 259: 3111–3116.PubMedGoogle Scholar
  8. Goldstein DB, Chin JH and Lyon RC (1982) EtOH disordering of spin-labeled mouse brain membranes: Correlation with genetic determined EtOH sensitivity of mice. Proc Natl Acad Sci USA 79: 4231–4233.PubMedCrossRefGoogle Scholar
  9. Gonzales RA and Crews FT (1984) Characterization of the cholinergic stimulation of phosphoinositide hydrolysis in rat brain slices. J Neurosci 4: 3120–3127.PubMedGoogle Scholar
  10. Gonzales RA and Crews FT (1985) Cholinergic and adrenergic stimulated inositide hydrolysis in brain: Interaction, regional distribution, and coupling mechanisms. J Neurochem 45: 1076–1084.PubMedCrossRefGoogle Scholar
  11. Gonzales RA and Crews FT (1985) Effect of ethanol and aging on histamine release and membranes of mast cells. Alcohol 2: 313–316.PubMedCrossRefGoogle Scholar
  12. Gonzales RA, Feldstein JB, Crews FT and Raizada MK (1985) Receptor mediated inositide hydrolysis is a neuronal response: Comparison of primary neuronal and glial cultures. Brain Res 345: 350–355.PubMedCrossRefGoogle Scholar
  13. Joseph SK (1984) Inositol trisphosphate: An intracellular messenger produced by Ca++ mobilizing hormones. Trends Biochem Sci 10: 420–421.CrossRefGoogle Scholar
  14. Kendall DA and Stephan RN (1984) Inositol phospholipid hydrolysis in rat cerebral cortical slices: II. Calcium requirement. J Neurochem 42: 1388–1394.PubMedCrossRefGoogle Scholar
  15. Kolesnick RN and Gershengorn MC (1984) Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells. J Biol Chem 259: 9514–9519.PubMedGoogle Scholar
  16. Lyon RC, McComb JA, Scheurs J and Goldstein DB (1981) A relationship between alcohol intoxication and the disordering of brain membranes by a series of short chain alcohols. J Pharmacol Exp Ther 218: 669–675.PubMedGoogle Scholar
  17. Rottenberg H, Waring A and Rubin E (1981) Tolerance and cross-tolerance in chronic alcoholics: Reduced membrane binding of ethanol and other drugs. Science 213: 583–584.PubMedCrossRefGoogle Scholar
  18. Seeman P (1972) The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 24: 583–655.PubMedGoogle Scholar
  19. Stokes JA and Harris RA (1982) Alcohol and synaptosomal calcium transport. Mol Pharmacol 22: 99–104.PubMedGoogle Scholar
  20. Wilkinson GN (1961) Statistical estimation in enzyme kinetics. Biochem J 80: 324–332.PubMedGoogle Scholar
  21. Wise BC, Raynor RL and Kuo JF (1981) Phospholipid-sensitive Ca-dependent protein kinase from heart. J Biol Chem 257: 8481–8488.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Fulton T. Crews
    • 1
  • Cynthia Theiss
    • 1
  • Robert Raulli
    • 1
  • Rueben A. Gonzales
    • 1
  1. 1.Department of Pharmacology and Therapeutics, J. Hillis Miller Health CenterUniversity of Florida School of MedicineGainesvilleUSA

Personalised recommendations