Phospholipid Metabolism in Nervous Tissues: Modification of Precursor Incorporation and Enzyme Activities by Cationic Amphiphilic Drugs
Although the effects of individual drugs on the incorporation of precursors into lipids in vitro have been sporadically examined for thirty years or so, it is primarily during the last ten years that a substantial body of information has been accumulated in this field. During this time, it has come to be recognized that numerous drugs with varied therapeutic actions share the capacity to redirect phospholipid metabolism. The compounds involved exhibit certain common physical-chemical features of their structures, namely a bulky lipophilic ring system and an aliphatic side-chain containing a quaternary, positively charged nitrogen which bestows hydrophilic character upon the molecule. The typical shift in incorporation of 32Pi into phospholipids, elicited by drugs of this type, manifests itself in enhanced labeling of acidic and reduced labeling of neutral phospholipids. This has been demonstrated in numerous biological systems (Hauser and Pappu, 1982; Abdel-Latif, 1983; Bazan et al., 1985).
KeywordsCytosolic Enzyme Phospholipid Metabolism Ethanolamine Phosphoglycerides Individual Phospholipid Class Phosphatidate Phosphohydrolase
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