Polyphosphoinositide Breakdown without Calcium Mobilization: Studies with Adrenal Chromaffin Cells and Retina

  • J. N. Hawthorne
  • F. A. Millar
  • A. M. F. Swilem
  • H. Yagisawa
Conference paper
Part of the FIDIA Research Series book series (FIDIA, volume 4)


The polyphosphoinositides (PtdIns4P and PtdIns(4, 5)P 2) have a considerable affinity for divalent cations and many years ago a physiological role in connection with calcium ions was suggested (Hawthorne and Kemp, 1964). In nervous tissue at least, the monoesterase and diesterase enzymes hydrolysing these lipids are much more active than the kinases responsible for their synthesis. The original description of PtdIns4P kinase by Kai et al. (1968) contains the following comment: “It (PtdIns(4, 5)P 2) resembles a transmitter substance in that the capacity for its destruction is very great”.


Chromaffin Cell Photoreceptor Cell Inositol Phosphate Inositol Trisphosphate Adrenal CHROMAFFIN Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. N. Hawthorne
    • 1
  • F. A. Millar
    • 1
  • A. M. F. Swilem
    • 1
  • H. Yagisawa
    • 1
  1. 1.Department of Biochemistry, Queen’s Medical CentreUniversity of Nottingham Medical SchoolNottinghamUK

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