Acute Tumor Lysis Syndrome

Prevention and Management
  • Stuart L. Marcus
  • Avi I. Einzig


Acute tumor lysis syndrome (ATLS) is a clinical entity that was first described in patients with either African or American Burkitt’s lymphoma who suffered sudden death within 2–3 days of treatment with chemotherapy.1 Initial observations suggested that hyperkalemia and renal failure occurring secondary to massive tumor lysis were responsible for patient demise. The syndrome associated with the treatment of tumors with very high rates of growth and rapid cell turnover is now expanded to include metabolic complications of hyperuricemia, hyperkalemia, and hyperphosphatemia with accompanying hypocalcemia (for recent reviews, see Cohen et al2 and Tsokos et al3) following chemotherapy. Certain of these complications, particularly hyperuricemia and renal failure, may also occur as the result of rapid cell turnover prior to treatment (see Section 2). This syndrome is almost exclusively associated with hematologic malignancies such as acute leukemia and malignant lymphoma, particularly Burkitt’s lymphoma (Table 1), diseases that have rapid cell proliferation but are also potentially curable, requiring aggressive treatment. ATLS in patients with solid tumors has been reported, however.5,9,10


Acute Renal Failure Serum Uric Acid Serum Uric Acid Level Tumor Lysis Syndrome Serum Urate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Stuart L. Marcus
    • 1
  • Avi I. Einzig
    • 2
  1. 1.Division of OncologyAlbert Einstein College of Medicine/Montefiore Medical CenterBronxUSA
  2. 2.Division of OncologyAlbert Einstein College of Medicine/Montefiore Medical CenterBronxUSA

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