Abstract
Obstipation is defined as “extreme” constipation, meaning practically an interruption of the gastrointestinal transit. Acute obstipation may arise de novo or may complicate an already chronic state of constipation. Obstipation in cancer patients may be due to the mechanical or metabolic effect of the tumor, may result from the use of antineoplastic drugs or of other drugs, or may be due to unrelated causes. Table 1 summarizes the causes of obstipation that arises in cancer patients.
Keywords
Multiple Endocrine Neoplasia Type Ricinoleic Acid Salmon Calcitonin Colonic Obstruction Cauda Equina Syndrome
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- 1.Lo AM, Evans WE, Carey LC: Review of small bowel obstruction at Milwaukee County General Hospital. Am J Surg 111: 884, 1966.PubMedCrossRefGoogle Scholar
- 2.Sise JG, Crichlow RW: Obstruction due to malignant tumors. Semin Oncol 5: 213–224, 1978.PubMedGoogle Scholar
- 3.McNeil JE: Mechanism of obstruction in carcinoid tumors of the small intestine. Am J Clin Pathol 56: 452, 1971.Google Scholar
- 4.Glass RL, Le Duc RJ: Small intestinal obstruction from peritoneal carcinomatosis. Am J Surg 125: 316, 1973.PubMedCrossRefGoogle Scholar
- 5.Ulin AW, Delement FA, James PM: Large bowel obstruction due to carcinoma. Am Fam Physician 3: 79, 1971.PubMedGoogle Scholar
- 6.Glenn F, McSherry CK: Obstruction and perforation in colorectal cancer. Ann Surg 173: 983, 1971.PubMedCrossRefGoogle Scholar
- 7.Welsch JP, Donaldson GA: Management of severe obstruction of the large bowel due to malignant disease. Am J Surg 127: 492, 1974.CrossRefGoogle Scholar
- 8.Thurtle OA, Allen AP, Walters MT, Kitchen JV, Smith CL, Cawley MD: Intractable constipation in malignant phaeochromocytoma: Combined treatment with adrenergic blockade and cholinergic drugs. J R Soc Med 77: 327–328, 1984.PubMedGoogle Scholar
- 9.Short IA, Padfield PL: Malignant pheochromocytoma with severe constipation and myocardial necrosis. Br Med J 20: 793–794, 1976.CrossRefGoogle Scholar
- 10.Hume DM: Pheochromocytoma in the adult and in the child. Am J Surg 99: 458–496, 1960.PubMedCrossRefGoogle Scholar
- 11.Cuthberg JA, Gallagher ND, Turtle JR: Colonic and oesophageal disturbance in a patient with multiple endocrine neoplasia, type IIb. Aust N Z Med 8: 518–520, 1978.CrossRefGoogle Scholar
- 12.Posner JB: Neurological complications of systemic cancer. Med Clin North Am 63: 783–800, 1979.PubMedGoogle Scholar
- 13.Veith RG, Odom GL: Extradural spinal metastases and their neurosurgical treatment. J Neurosurg 23: 501–508, 1965.CrossRefGoogle Scholar
- 14.Arseni CN, Simionescu MD, Horwath L: Tumors of the spine: A follow-up study of 350 patients with neurosurgical considerations. Acta Psychiatr Scand 34: 398–410, 1959.PubMedCrossRefGoogle Scholar
- 15.Rodriguez M, Dinapoli RP: Spinal cord compression with special reference to metastatic epidural tumors. Mayo Clin Proc 55: 442–448, 1980.PubMedGoogle Scholar
- 16.Petursson SR, Boggs DR: Spinal cord involvement in leukemia: A review of the literature and a case of Ph’ + acute myeloid leukemia presenting with a tonus medullaris syndrome. Cancer 47: 346–350, 1981.PubMedCrossRefGoogle Scholar
- 17.Olsen CW: Leukemia as a cause of cauda equina syndrome. Bull Los Angeles Neurol Soc 1: 9598, 1935.Google Scholar
- 18.Gilbert RW, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Diagnosis and treatment. Ann Neurol 3: 40–51, 1978.PubMedCrossRefGoogle Scholar
- 19.Silvis RS, Riddle LR, Clark GG: Anterior sacral meningocele. Am Surg 22: 554–566, 1956.PubMedGoogle Scholar
- 20.Anderson FM, Burke BL: Anterior sacral meningocele. J Am Med Assoc 237: 39–42, 1977.CrossRefGoogle Scholar
- 21.Fields AL, Josee RG, Bergsagel DE: Metabolic emergencies, in De Vita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Toronto, JB Lippincott, 1982, pp 1594–1604.Google Scholar
- 22.Mundy GR, Martin TJ: Hypercalcemia of malignancy: Pathogenesis and treatment. Metabolism 31: 1247–1277, 1982.PubMedCrossRefGoogle Scholar
- 23.Mundy GR, Raisz LG, Cooper RA, Schechter GP, Salmon SE: Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Eng J Med 291: 1041–1046, 1974.CrossRefGoogle Scholar
- 24.Raisz LG, Simmons HA, Sandberg AL, Canalis E: Direct stimulation of bone resorption by epidermal growth factor. Endocrinology 107: 270–273, 1980.PubMedCrossRefGoogle Scholar
- 25.Fillastre JP, Humbert G, Leroy J, et al: Furosemide, mithramycin and salmon calcitonin in hypercalcemia. Eur J Intensive Care Med 1: 185, 1975.CrossRefGoogle Scholar
- 26.Boyle IT, Foeglman I: Glucocorticoids and estrogens in the management of hypercalcemia. Met Bone Dis Rel Res 2: 203, 1980.CrossRefGoogle Scholar
- 27.Mannheimer IH: Hypercalcemia of breast cancer. Cancer 18: 679, 1965.PubMedCrossRefGoogle Scholar
- 28.Slayton RE, Shnider BI, Elias E, et al: New approaches to the treatment of hypercalcemia: The effect of short-term treatment with mithramycin. Clin Pharmacol Ther 12: 833, 1971.PubMedGoogle Scholar
- 29.Binstock ML, Mundy GR: Effect of calcitonin and glucocorticoids in combination on the hypercalcemia of malignancy. Ann Intern Med 93: 269, 1980.PubMedCrossRefGoogle Scholar
- 30.Wisneski LA, Croom WP, Silva OK, et al: Salmon calcitonin in hypercalcemia. Clin Pharmacol Ther 24: 219, 1978.PubMedGoogle Scholar
- 31.Jaffe JH, Martin WR: Opioid analgesics and antagonists, in Goodman-Gilman A, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics, 6th ed. New York, Macmillan, 1980, pp 494–534.Google Scholar
- 32.Valdivieso M, Richman S, Burgess AM, Bodey DP, Freireich EJ: Initial clinical studies of vindesine. Cancer Treatment Rep 65: 873–875, 1981.Google Scholar
- 33.Neely J, Catchpole B: Ileus: The restoration of alimentary mobility by pharmacological means. Br J Surg 58: 21, 1971.PubMedCrossRefGoogle Scholar
- 34.Binder MJ, Donowitz M: A new look at laxative action. Gastroenterology 69: 1001–1005, 1975.PubMedGoogle Scholar
- 35.Pietruski RG: Use and abuse of laxatives. AM J Hosp Pharm 34: 291–300, 1977.Google Scholar
- 36.Stewart JY, Bass P: Effects of ricinoleic and oleic acids on the digestive contractile activity of the canine small and large bowel. Gastroenterology 70: 371–376, 1976.PubMedGoogle Scholar
- 37.Garginella TS, Phillips SF: Ricinoleic acid (castor oil) alters intestinal surface structure. Mayo Clin Proc 51: 6–12, 1976.Google Scholar
- 38.Hardcastle JD, Wilkins JL: The action of semnosides and related compounds on human colon and rectum. Gut 11: 1038–1042, 1970.PubMedCrossRefGoogle Scholar
- 39.Knowles JA: Effects on the infant of drug therapy in nursing mothers. Drug Ther 3: 57–65, 1973.Google Scholar
- 40.Sterr HW, Colin-Jones DG: Melanosis coli: Studies of the toxic effects of irritant purgatives. J Pathol 115: 199–205, 1975.CrossRefGoogle Scholar
- 41.Donovitz M: Current concepts of laxative action: Mechanisms by which laxatives increase stool water. Gastroenterology 1: 77–84, 1979.Google Scholar
- 42.Mordeo JP, Schwartz R, Arky RA: Extreme hypermagnesemia as a cause of refractory hypotension. Ann Intern Med 83: 657–658, 1975.CrossRefGoogle Scholar
- 43.Tedesco FJ, DiPiro JT: Laxative use in constipation. Am J Gastroenterol 80: 303–309, 1985.PubMedGoogle Scholar
Copyright information
© Springer Science+Business Media New York 1987