Advertisement

Typhlitis and Related Acute Gastrointestinal Problems

  • Peter H. Wiernik

Abstract

Typhlitis is a necrotizing lesion of the cecum and adjacent colon that occurs in a setting of cancer chemotherapy and neutropenia. It is primarily a complication experienced by acute leukemia patients, but it has also been observed in patients with the more common solid tumors.1 Typhlitis often presents as an acute intraabdominal emergency. It may require surgical intervention, but in many instances it may be successfully managed medically. Typhlitis is a potentially grave complication, and irrespective of management, the outcome is often death. Early recognition of the problem, and guidelines for surgical intervention, may improve the outcome of patients with this complication.

Keywords

Acute Leukemia Cytosine Arabinoside Acute Leukemia Patient Pneumatosis Cystoides Intestinalis Neutropenic Enterocolitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Starnes HF Jr, Moore FD Jr, Mentzer S, et al: Abdominal pain in neutropenic cancer patients. Cancer 57: 616 - 621, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    Lea JW Jr, Masys DR, Shackford SR: Typhlitis: A treatable complication of acute leukemia therapy. Cancer Clin Trials 3: 355 - 362, 1980.PubMedGoogle Scholar
  3. 3.
    Shamberger RC, Weinstein HJ, Delorey MJ, et al: The medical and surgical management of typhlitis in children with acute nonlymphocytic (myelogenous) leukemia. Cancer 57: 603 - 609, 1986.PubMedCrossRefGoogle Scholar
  4. 4.
    Steinberg D, Gold J, Brodin A: Necrotizing enterocolitis in leukemia. Arch Intern Med 131: 538 - 544, 1973.PubMedCrossRefGoogle Scholar
  5. 5.
    Dosik GM, Luna M, Valdivieso M, et al: Necrotizing colitis in patients with cancer. Am J Med 67: 646 - 656, 1979.PubMedCrossRefGoogle Scholar
  6. 6.
    Slavin RE, Dias MA, Saral R: Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols. Cancer 42: 1747 - 1759, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Moir DH, Bale PM: Necropsy findings in childhood leukemia, emphasizing neutropenic enterocolitis and cerebral calcification. Pathology 8: 247 - 258, 1976.PubMedCrossRefGoogle Scholar
  8. 8.
    Rifkin GD: Neutropenic enterocolitis and Clostridium septicum infection in patients with agranulocytosis. Arch Intern Med 140: 834 - 835, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Jaffe N, Carlson D, Vawter GF: Pneumatosis cystoides intestinalis in acute leukemia. Cancer 30: 239 - 243, 1972.PubMedCrossRefGoogle Scholar
  10. 10.
    Bishop JF, Schiffer CA, Aisner J: Surgery in acute leukemia: A review of 167 operations in thrombocytopenic patients. J Clin Oncol (in press).Google Scholar
  11. 11.
    Johnson H, Smith TJ, Desforges J: Cytosine-arabinoside-induced colitis and peritonitis: Non-operative management. J Clin Oncol 3: 607 - 612, 1985.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Peter H. Wiernik
    • 1
    • 2
    • 3
  1. 1.Department of OncologyMontefiore Medical CenterBronxUSA
  2. 2.Division of Medical OncologyAlbert Einstein College of MedicineBronxUSA
  3. 3.Albert Einstein Cancer CenterBronxUSA

Personalised recommendations