Extreme thrombocytosis is noted in a variety of clinical situations. The potential for complications appears to be related to the underlying clinical problem, rather than to the absolute platelet count alone. For example, extreme thrombocytosis represents a potentially ominous complication of a number of hematologic disorders, including polycythemia vera and essential thrombocytosis, and may be associated with thrombotic or hemorrhagic complications. Even in these disorders, however, thrombocytosis may be entirely asymptomatic; therefore, the treatment of extreme thrombocytosis in the asymptomatic patient remains controversial. However, symptomatic patients appear to benefit from the lowering of the platelet count or the use of antiplatelet medication or both. Table 1 lists the disorders associated with thrombocytosis.
KeywordsChronic Myelogenous Leukemia Iron Deficiency Anemia Polycythemia Vera Thrombotic Complication Myeloproliferative Disorder
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