Meningeal Leukemia and Carcinomatosis
The term “neoplastic meningitis” refers to diffuse or multifocal seeding of the leptomeninges by tumor cells. Pure neoplastic meningitis is defined by the presence of leptomeningeal involvement by tumor cells in the absence of concomitant malignant metastasis in the brain or spinal cord. Primary leptomeningeal tumors such as primary melanomatosis or primary glioblastomatosis are exceptionally rare (Table 1). Secondary neoplastic meningitis can be divided into two groups. The first includes meningeal leukemias and lymphomas, and the second includes leptomeningeal metastases of solid tumor, the so-called “meningeal carciomatosis.”
KeywordsChronic Lymphocytic Leukemia Cranial Nerve Palsy Leptomeningeal Metastasis Fuse Category Central Nervous System Metastasis
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