Mapping by the MTD Method of a Catecholamine Receptor Implied in the Ionic Permeability of Cell Membranes

  • Z. Simon
  • N. Dragomir
  • G. I. Mihalas
  • M. G. Plauchithiu
  • Tamara Bânzaru

Abstract

The action of adrenaline and adrenaline agonists, upon the alpha adrenergic receptors, produces an increase of the permeability for K+, which is related to an increase of Ca2+- concentration on the inner side of the membrane. The alpha adrenergic receptor can exist in two, relatively stable conformations — the antagonistic, inactive conformation and the agonistic conformation, induced by adrenaline and its agonistsl. The ionophoricf unction of the agonistic receptor conformation is, probably, responsible for the Ca2+ increase2.

Keywords

Phenyl Ethyl Amine Alpha Adrenergic Receptor Hydrophobic Site Inactive Conformation Receptor Conformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Z. Simon
    • 1
  • N. Dragomir
    • 1
  • G. I. Mihalas
    • 1
  • M. G. Plauchithiu
    • 1
  • Tamara Bânzaru
    • 1
  1. 1.Department of Biophysics and Department of PharmacologyInstitute of MedicineTimisoaraRomania

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