Abstract
The action of adrenaline and adrenaline agonists, upon the alpha adrenergic receptors, produces an increase of the permeability for K+, which is related to an increase of Ca2+- concentration on the inner side of the membrane. The alpha adrenergic receptor can exist in two, relatively stable conformations — the antagonistic, inactive conformation and the agonistic conformation, induced by adrenaline and its agonistsl. The ionophoricf unction of the agonistic receptor conformation is, probably, responsible for the Ca2+ increase2.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.C. U. Pritchard, D. A. Greenberg and S.H. Snyder: Mol.Pharmacol. 13, 45 (1977)
D.H.Jenkinson, D.G.Haylett and K.Koller,in “Cell Membrane Receptors for Drugs and Hormones. A Multidisciplinary Approach”, R.W.Straub and Liana Bolis,editors, Raven Press, New York 1978, pp 89–1o5
L. T. William s and R. J. Lefkovitz: “Receptor Binding Studies Adrenergic Pharmacology”, Raven Press, New York 1978, Chap.6
E.J.Ariens: Adv.Drug Res. 3, 235 (1966)
A. T. Balaban, A. Chiriac, I. Motoc and Z.Simon: “Steric Fit in Quantitative Structure Activity Relations”, Lecture Notes in Chem Ser., vol.15. ‚Springer, Heidelberg, 1980, Chap.5
Z.Simon, N. Dragomir, M.G.Plauchithiu, H. Glatt and F. Kerek: Eur. J. Medic. Chem 15 521 (1980)
S.Holban, D.Ciubotariu and G.I.Mihala: in preparation
R.F.Rekker: “The Hydrophobic Fragmental Constant”,Elsevier, Amsterdam, New York, 1977, Appendix
B.Belleau: Ann.N.Y.Acad.Sci. 139, 586 (1967)
M.G.Plauchithiu, M. Rocsin and Z.Simon: Rev. Roumaine Biochim. 15, 67 (1978)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer Science+Business Media New York
About this chapter
Cite this chapter
Simon, Z., Dragomir, N., Mihalas, G.I., Plauchithiu, M.G., Bânzaru, T. (1985). Mapping by the MTD Method of a Catecholamine Receptor Implied in the Ionic Permeability of Cell Membranes. In: Pullman, A., Vasilescu, V., Packer, L. (eds) Water and Ions in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0424-9_75
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0424-9_75
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0426-3
Online ISBN: 978-1-4899-0424-9
eBook Packages: Springer Book Archive