Water and DNA-Drug Interaction

  • Günter Löber
  • Renate Klarner


Several biologically active compounds are capable of forming intermolecular non-covalent complexes with deoxyribonucleic acid (DNA) under free energy changes of less than 40 kJ/mol (approximately 10 kcal/mol)[1–4]. These complexes are in the first place investigated on isolated DNA. There is, however, indication that they are also present in biological systems, where the nucleic acids exist in their natural state[5,6].


Organic Solvent Human Serum Albumin Acridine Orange Singlet Ground State Tertiary Butanol 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Günter Löber
    • 1
  • Renate Klarner
    • 1
  1. 1.Acad. of Sci. of the GDR, Department of Drugs and IsotopesCentral Institute of Microbiology and Experimental TherapyJenaGermany

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