Abstract
Isotope effects have become important for elucidating reaction mechanisms, for increasing the biological half-life of drugs, for studying metabolic pathways, etc. Several books 1 and reviews 2 have been devoted to isotope effects.
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References
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Balaban, A.T. (1985). Steric Versus Electronic Components of Secondary Deuterium Isotope Effects Depend on the Size of Electrophilic Probes. In: Pullman, A., Vasilescu, V., Packer, L. (eds) Water and Ions in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0424-9_63
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DOI: https://doi.org/10.1007/978-1-4899-0424-9_63
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