Analysis of Proton Translocation Through Hydrogen-Bonded Chains Using Molecular Orbital Methods
The chemiosmotic hypothesis has come to be one of the most widely accepted and useful concepts in biochemistry [1–5]. A basic tenet of this theory is that energy may be transduced across a biomembrane via a protonmotive force which is capable of pushing protons against a pH gradient and/or electric field. Bacteriorhodopsin, for example, is known to function as a “proton pump” when it is energized by light of the proper frequency [6–9]. The energy stored in a pH gradient may be harnessed for the purpose of biological work when protons are allowed to be transported across the membrane in much the same way that discharge of an electric capacitor is a source of energy. The synthesis of ATP by H+-ATPase is thought to be driven by the passage of protons through the F0 segment of the transmembrane protein [5,10–13].
KeywordsProton Transfer Protein Residue Proton Transfer Process Linear Configuration Molecular Orbital Method
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