Ion Permeability and Membrane Potential in Viral Disease
The ionic content of cells is an important determinant of their function. A raised intracellular Na+ in lens cells has been shown to be a direct cause of cataract (Piatigorsky, 1980) and changes in intracellular monovalent cations, as well as in Ca2+ have been implicated in diseases varying from hepatitis (Alam et al., 1978) to hypertension (Reid, 1982; Swales, 1982). Indeed, in many diseases in which the surface membrane of cells is primarily affected, it is an altered cation content that appears to be at fault (Griffin and Pasternak, 1982). Following our observation that certain viruses make cells permeable to low molecular weight compounds and ions without lysis (Pasternak and Micklem, 1973, 1974), we have been studying the effects of viruses on surface membrane function: our aim has been to determine to what extent such changes underly the processes of viral infection and disease. In this report we concentrate on changes in ion permeability and membrane potential.
KeywordsMembrane Potential Excitable Cell Sendai Virus Semliki Forest Virus Lens Cell
Unable to display preview. Download preview PDF.
- Gillies, G., Micklem, K.J. and Pasternak, C.A., 1981, Cell Biol. Int.Rep., Suppl. A, 5: 20.Google Scholar
- Gomperts, B., Micklem, K.J. and Pasternak, C.A., 1981, Cell Biol. Int.Rep., Suppl. A, 5: 20.Google Scholar
- Gomperts, B.D., Baldwin, J.M. and Micklem, K.J., 1983, Biochem.J., in press.Google Scholar
- Knutton, S., 1978, Micron, 9: 133.Google Scholar
- Okada, Y., Koseki, I., Kim, J., Maeda, Y., Hashimoto, T., Kanno, Y. and Matsui, Y., 1975, Exp.Cell Res., 93: 368.Google Scholar
- Pasternak, C.A., 1983, Virally-mediated changes in cellular permeability. In: Membrane Processes: Molecular Biological Aspects and Medical Applications, G. Benga, H. Baum and F. Kummerow, eds., Springer Verlag, New York, in press.Google Scholar
- Pasternak, C.A. and Micklem, K.J., 1983, Altered function of excitable cells caused by paramyxoviruses. In: Viruses and demyelinating diseases, C.A. Mims, ed., Academic Press, London, in press.Google Scholar
- Pasternak, C.A., Strachen, E., Micklem, K.J. and Duncan, J., 1976, New approaches for studying surface membranes. In: Cell surfaces and malignancy, P.T. Mora, ed., U.S. GovernmentGoogle Scholar
- Printing Office, Washington DC, Fogarty Int.Center Proc.28. Philo, R.D. and Eddy, A.A., 1978, Biochem.J., 174: 801.Google Scholar
- Piatigorsky, J., 1980, Current Topics in Eye Research, 3:1. Pietrzyk, C., Geck, P. and Heinz, E., 1978, Biochim.Biophys.Acta, 513: 89.Google Scholar
- Poste, G. and Pasternak, C.A., 1978, Cell Surface Revs., 5:306. Reid, J.L., ed., 1982, Proc.Ninth Meeting Int.Soc.Hypertension, Clin.Sci., 63: Suppl. 8.Google Scholar