Advertisement

Mechanisms of Proton-Hydroxide Flux Across Membranes

  • David W. Deamer
  • J. Wylie Nichols

Abstract

In both model and biological membranes, measurements of proton-hydroxide flux produce permeability coefficients that are orders of magnitude greater than those obtained with other monovalent ions. As a working hypothesis, we suggest that this large variance can be explained by the flux of protons along hydrogenbonded strands of associated water or protein in the hydrophobic plane of the membrane.

Keywords

Permeability Coefficient Diffusion Potential Proton Flux Liposome System Proton Equivalent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hauser, H., Oldani, D. and Phillips, M.C. Biochemistry 12: 4507 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    Nozaki, Y. and Tanford, C. Proc. Natl. Acad. Sci. USA 78: 4324 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    Papahadjopoulos, D., Nir, S. and Ohki, S. Biochim. Biophys. Acta 266: 561 (1972).PubMedCrossRefGoogle Scholar
  4. 4.
    Nichols, J.W., Hill, M.W., Bangham, A.D. and Deamer, D.W. Biochim. Biophys. Acta 596: 393 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    Rossignol, M., Thomas, P. and Grignon, C. Biochim. Biophys. Acta 684: 195 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    Pohl, W.G. Z. Naturforsch 37c: 120 (1982).Google Scholar
  7. 7.
    Biegel, C.M. and Gould, J.M. Biochemistry 20: 3474 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    Nichols, J.W. and Deamer, D.W. Proc. Natl. Acad. Sci. USA 77: 2038 (1980).PubMedCrossRefGoogle Scholar
  9. 9.
    Deamer, D.W. and Nichols, J.W. Proc. Natl. Acad. Sci. USA 80:1983 (in press).Google Scholar
  10. 10.
    Elamrani, K. and Blume A. Biochim. Biophys. Acta (in press).Google Scholar
  11. 11.
    Gutknecht, J. and Walter, A. Biochim. Biophys. Acta 641: 183 (1981).PubMedCrossRefGoogle Scholar
  12. 12.
    Hopfer, V., Lehninger, A.L. and Lennarz, W.J. J. Membrane Biol. 2: 41 (1970).CrossRefGoogle Scholar
  13. 13.
    Papahadjopoulos, D. and Ohki, S. In Surface Chemistry of Biological Systems. Plenum Press, 1970. pp. 155–173.Google Scholar
  14. 14.
    Cafiso, D. and Hubbel, W. Biophys. J. 33: 114a (1981).Google Scholar
  15. 15.
    Bangham, A.D., DeGier, J. and Greville, G.D. Chem. Phys. Lipids 1: 225 (1967).CrossRefGoogle Scholar
  16. 16.
    Griffith, 0.H., Dehlinger, P.J. and Van, S.P. J. Membrane Biol. 15: 159 (1974).Google Scholar
  17. 17.
    Cass, A. and Finkelstein, A. J. Gen. Physiol. 50: 1756 (1784).Google Scholar
  18. 18.
    Eigen, M. and DeMaeyer, L. Proc. R. Soc. London Ser A 247: 505 (1958).CrossRefGoogle Scholar
  19. 19.
    Kanehisa, I.M. and Tsong, T.Y. J. Am. Chem. Soc. 100: 424 (1978).CrossRefGoogle Scholar
  20. 20.
    Papahadjopoulos, D., Jacobson, K., Nir, S. and Isac, T. Biochim. Biophys. Acta 311: 330 (1973).PubMedCrossRefGoogle Scholar
  21. 21.
    Peterson, D.C. Biochim. Biophys. Acta 600: 666 (1980).CrossRefGoogle Scholar
  22. 22.
    Katz, B. In Nerve, Muscle and Synapse. McGraw-Hill, p. 61. (1966).Google Scholar
  23. 23.
    Nagle, J.F. and Morowitz, H.J. Proc. Natl. Acad. Sci. USA 75: 298 (1978).PubMedCrossRefGoogle Scholar
  24. 24.
    Edmonds, D. Biochem. Soc. Symp. 46:91 (1980). London: The Biochemical Society.Google Scholar
  25. 25.
    Gutknecht, J. and Walter A. Biochim. Biophys. Acta 645: 161 (1981).CrossRefGoogle Scholar
  26. 26.
    Mitchell, P. and Moyle, J. Biochem. J. 104: 588 (1967).PubMedGoogle Scholar
  27. 27.
    Itzuzu, K.T. J. Physiol. (Lond) 221: 15 (1972).Google Scholar
  28. 28.
    Meissner, G. and Young, R.C. J. Biol. Chem. 255: 6814 (1980).PubMedGoogle Scholar
  29. 29.
    Crandall, E.D., Klocke, R.A. and Forster, R.E. J. Gen. Physiol. 57: 664 (1971).CrossRefGoogle Scholar
  30. 30.
    Pitman, M.G., Anderson, W.P. and Schaefer, N. In Regulation of Cell Membrane Activities in Plants. Marre E. and Ciferri 0. eds. pp. 147–160. North Holland, Amsterdam (1977).Google Scholar
  31. 31.
    Scheiner, S. Ann. New York Acad. Sci. 367: 493 (1981).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • David W. Deamer
    • 1
  • J. Wylie Nichols
    • 2
  1. 1.Department of ZoologyUniversity of CaliforniaDavisUSA
  2. 2.Department of PhysiologyEmory Univ. Medical SchoolAtlantaUSA

Personalised recommendations