Theoretical Models for Calcium Channels in Nerve Cells
One of the important problems in modern biophysics is determination of the structure and function of different ionic channels in various excitable tissues. During the past three decades it became well established that there are three main types of ionic channels which differ in their kinetic, selective and pharmacological properties. These are sodium, potassium and calcium channels. Among them calcium channels appear to play the most significant role in the functioning of nerve cells (see, e.g. Llinas, 1979; Kostyuk, 1981). The reason for this lies in the fact that these channels are responsible not only for the electrical behaviour of nerve cells, but also provide a pathway for calcium ions into the cell. Entering the nerve cell Ca ions can trigger many different biochemical reactions related to the functioning, differentiation and proliferation of nerve cells (Minas, 1979; Kostyuk, 1981).
KeywordsCalcium Channel Carboxylic Group Nerve Cell Energy Profile Extracellular Solution
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- Hille, B., 1979, Ionic selectivity of Na and K channels of nerve membranes, in: “Membranes. A Series of Advances”, G. Eisenman, ed., Marcel Dekker, New YorkGoogle Scholar
- Kostyuk, P. G., and Mironov, S. L., 1982, Theoretical description of calcium channels in the neuronal membrane, Gen. Physiol. Biophys., 1:289Google Scholar
- Kostyuk, P. G., Mironov, S. L., and Doroshenko, P. A., 1982a, Energy profile of the calcium channel in the membrane of mollusc neurons, J. Memb. Biol., 70: 181.Google Scholar
- Llinas, R., 1979, The role of calcium in neuronal function, in: “Neurosciences: Fourth Study Program”, F. O. Schmitt, and F. G. Worden, eds., MIT Press, New York.Google Scholar
- Mironov, S. L., 1982, The comparison of the selective filters of sodium and calcium channels in excitable membrane, Dokl. Akad. Nauk SSSR (Moscow), 268: 731.Google Scholar
- Mironov, S. L., 1983, Modeling of oscillatory electric activity of molluscan neurons, Neurophysiology (Kiev), 15: 3.Google Scholar