Volume Regulation in Carp Kidney Tissue as Influenced by Various Osmotic Agents
To what extent does the sodium pump (the plasma membrane Na,K-ATPase)contribute to volume regulation of animal cells? According to the original concept of Wilson (1954) and Leaf (1956) the sodium pump solves entirely the problem of volume maintenance in isotonic media, since “effectively impermeant” sodium ions (continually extruded by the pump) compensate for the Donnan excess of osmotic pressure, resulting mostly from the high concentration of diffusible counterions of macromolecules in the cytoplasm.
KeywordsVolume Regulation Tissue Slice Sodium Pump Osmotic Agent Frog Urinary Bladder
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- Benes, I., Tauchova, R., and Janacek, K., 1982, Ouabain-insensitive mechanism of cell volume maintenance in the carp kidney, Physiol. boh.emoslov. 31: 237.Google Scholar
- Benes, I., Janacek, K., and Tauchovâ, R., 1983, Cell water content in carp kidney tissue slices as influenced by various osmotic agents, Physiol. bohemoslov., in press.Google Scholar
- Janacek., K., Rybova, R., and Slavíkova, M., 1971, Independent stimulation of sodium entry and sodium extrusion in frog urinary bladder by aldosterone, Pflügers Arch., 326: 316.Google Scholar
- Kleinzeller, A., 1972, Cellular transport of water, in: “Metabolic Pathways: Metabolic Transport,” L. E. Hokin, ed.,Vol. 6, Academic Press, New York (1972).Google Scholar
- Ling, G. N., 1982, The physical state of K+ and water in the living cell according to the association-induction hypothesis and experimental evidence, in: Second International Conference on Water and Ions in Biological Systems, Abstracts, Bucharest.Google Scholar
- Macknight, A. D. C., and Leaf, A., 1974, Regulation of cellular volume, Physiol. Rev., 57: 510.Google Scholar
- Negendank, W., and Shaller, C., 1982, Isoosmotic volume regulation by human lymphocytes, in: Second International Conference on Water and Ions in Biological Systems, Abstracts, Bucharest.Google Scholar