Taurine Efflux from Brain Slices: Potassium-Evoked Release is Greater from Immature than Mature Brain Tissue
Taurine is a free amino acid abounding in all brain regions, being enriched in synaptic structures (14). The concentration of taurine is very high in the developing brain, decreasing towards adulthood, a pattern in striking contrast to that of other neuroactive amino acids, whose concentrations tend to increase during development (26). It has therefore been suggested that taurine may have a specific regulatory role in brain development (24,32). In order to shed light on the functions of taurine in the developing brain, we compared the mechanisms of spontaneous and potassium-stimulated taurine release from slices prepared from adult and immature brain tissue.
KeywordsTaurine Release Taurine Content Taurine Efflux Nipecotic Acid Basal Efflux
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