Development of Biosynthesizing and Uptake Systems for Taurine in Cerebral Cortical Neurons in Primary Culture: Analysis of Possible Factors Involved in Perinatal Decline of Cerebral Taurine

  • Kinya Kuriyama
  • Seitaro Ohkuma
  • Masataka Kishi
  • Misa Kimori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


It is well known that taurine (2-aminoethanesulfonic acid), one of most highly concentrated neuroactive amino acids in the mammalian CNS, exhibits a postnatal decline in the brain, which is different from the developmental elevation of the content of other neurotransmitters during the maturation of CNS (1,2,11,15). On the other hand, it has been reported that the activities of cysteine sulfinic acid decarboxylase (CSAD) and cysteine dioxygenase (CD), enzymes involved in taurine biosynthesis from cysteine, show an increase after birth (3,9,12).


Primary Culture Neuron CYSTEIC Acid Taurine Content Cerebral Cortical Neuron Taurine Uptake 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Kinya Kuriyama
    • 1
  • Seitaro Ohkuma
    • 1
  • Masataka Kishi
    • 1
  • Misa Kimori
    • 1
  1. 1.Department of PharmacologyKyoto Prefectural University of MedicineKawaramachi-Hirokoji, Kamikyo-Ku, Kyoto 602Japan

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