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Development of Biosynthesizing and Uptake Systems for Taurine in Cerebral Cortical Neurons in Primary Culture: Analysis of Possible Factors Involved in Perinatal Decline of Cerebral Taurine

  • Kinya Kuriyama
  • Seitaro Ohkuma
  • Masataka Kishi
  • Misa Kimori
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

It is well known that taurine (2-aminoethanesulfonic acid), one of most highly concentrated neuroactive amino acids in the mammalian CNS, exhibits a postnatal decline in the brain, which is different from the developmental elevation of the content of other neurotransmitters during the maturation of CNS (1,2,11,15). On the other hand, it has been reported that the activities of cysteine sulfinic acid decarboxylase (CSAD) and cysteine dioxygenase (CD), enzymes involved in taurine biosynthesis from cysteine, show an increase after birth (3,9,12).

Keywords

Primary Culture Neuron CYSTEIC Acid Taurine Content Cerebral Cortical Neuron Taurine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Agrawal, H.C., Davis, J.M., and Himwich, W.A., 1966, Postnatal changes in free amino acid pool of rat brain, J. Neurochem., 13:607–615.PubMedCrossRefGoogle Scholar
  2. 2.
    Agrawal, H.C., Davis, J.M., and Himwich, W.A., 1968, Developmental changes in mouse brain: Weight, water content and free amino acids, J. Neurochem., 23:917–923.CrossRefGoogle Scholar
  3. 3.
    Agrawal, H.C., Davison, A.N., and Kaczmarek, L.K., 1971, Subcellular distribution of taurine and cystelne sulphinate decarboxylase in developing rat brain, Biochem. J., 122:759–763.PubMedGoogle Scholar
  4. 4.
    Bignami, A., and Dahl, D., 1974, Astrocyte specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein, J. Comp. Neurol., 153:27–38.PubMedCrossRefGoogle Scholar
  5. 5.
    Hruska, R.E., Huxtable, R.J., and Yamamura, H.I., 1978, High affinity, temperature-sensitive, and sodium-dependent transport in rat brain, in: “Taurine and Neurological Disorders”, A. Barbeau and R.J. Huxtable, eds., Raven Press, New York, pp. 109–177.Google Scholar
  6. 6.
    Ida, S., and Kuriyama, K., 1983, Simultaneous determination of cysteine sulfinic acid and cysteic acid in rat brain by high performance liquid chromatography, Anal. Biochem., 130:95–101.PubMedCrossRefGoogle Scholar
  7. 7.
    Kimura, H., McGeer, P.L., Peng, J.H., and McGeer, E.G., 1981, The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat, J. Comp. Neurol., 200:151–201.PubMedCrossRefGoogle Scholar
  8. 8.
    Lahdesmaki, P., and Oja, S.S., 1972, Effect of electrical stimulation on the influx and efflux of taurine in brain slices of newborn and adult rats, Exp. Brain Res., 15:430–438.PubMedCrossRefGoogle Scholar
  9. 9.
    Misra, C.H., and Olney, J.W., 1975, Cysteine oxidase in brain, Brain Res., 97:117–126.PubMedCrossRefGoogle Scholar
  10. 10.
    Ohkuma, S., Tomono, S., Tanaka, Y., Kuriyama, K., and Mukainaka, T., 1986, Development of taurine biosynthesizing system in cerebral cortical neurons in primary culture, Int. J. Devl. Neuroscience, 4:383–395.CrossRefGoogle Scholar
  11. 11.
    Oja, S.S., and Piha, R.S., 1966, Changes in the concentration of free amino acids in the rat brain during postnatal development, Life Sci., 5:865–870.PubMedCrossRefGoogle Scholar
  12. 12.
    Pasantes-Morales H., Mapes, C, Tapia, R., and Mandel, P., 1976, Properties of soluble and particulate cysteine sulfinate decarboxylase of adult and the developing rat brain, Brain Res., 107:575–589.PubMedCrossRefGoogle Scholar
  13. 13.
    Pope, A., 1978, Neuroglia: in: “Dynamic Properties of Glial Cells”, E. Schoffeniels, G. Franck, L. Hertz, and D.B. Tower, eds., Pergamon Press, Oxford, pp. 13–20.Google Scholar
  14. 14.
    Sturman, J.A., 1973, Taurine pool sizes on the rat: Effects of vitamin B6 deficiency and high taurine diet, J. Nutr., 103:1566–1580.PubMedGoogle Scholar
  15. 15.
    Sturman, J.A., and Gaull, G.E., 1975, Taurine in the brain and the liver of the developing human and monkey, J. Neurochem., 25:831–835.PubMedCrossRefGoogle Scholar
  16. 16.
    Sturman, J.A., Rassin, D.K., and Gaull G.E., 1977, Taurine in developing rat brain: Maternal-fetal transfer of [35S]taurine and its fate in the neonate, J. Neurochem., 28:31–39.PubMedCrossRefGoogle Scholar
  17. 17.
    Sturman, J.A., Rassin, D.K., and Gaull, G.E., 1977, Taurine in developing rat brain: Transfer of [35S]taurine to pups via the milk, Pediatr. Res., 11:28–33.PubMedGoogle Scholar
  18. 18.
    Tomida, Y., Ida, S., Kuriyama, K., and Kimura, H., 1986, Production and characterization of antibodies against taurine and its immunohisto-chemical application in the CNS, Neurochem. Res., in press.Google Scholar
  19. 19.
    Yoneda, Y., Takashima, S., Hirai, K., Kurihara, E., Yukawa, Y., Tokunaga, H., and Kuriyama, K., 1977, Microassay methods for taurine and cysteine sulfinate decarboxylase activity, Jap. J. Pharmacol., 27:881–888.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Kinya Kuriyama
    • 1
  • Seitaro Ohkuma
    • 1
  • Masataka Kishi
    • 1
  • Misa Kimori
    • 1
  1. 1.Department of PharmacologyKyoto Prefectural University of MedicineKawaramachi-Hirokoji, Kamikyo-Ku, Kyoto 602Japan

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