Effects of Acidic Dipeptides on Aminoacidergic Neurotransmission in the Brain

  • V. Varga
  • Kirsi-Marja Marnela
  • Pirjo Kontro
  • J. Gulyás
  • Z. Vadász
  • P. Lähdesmäki
  • S. S. Oja
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


Among the numerous oligopeptides found in the brain the small acidic peptides have received little attention, although their existence has long been known (5, 6, 36, 38). These substances are often acetylated and contain aspartate, glutamate, serine, glycine, alanine and taurine in various combinations (9, 30, 37, 40). Of the taurine-containing peptides the most plentiful and best known is L-glutamyl-taurine (31), which exists in two forms, alpha and gamma, in approximately equal amounts in calf brain synaptic vesicles (32). Their origin is still obscure, although the biosynthesis of γ-glutamyl-taurine has been shown to be catalyzed by γ-glutamyl-transferase (42). Various effects have been attributed to γ-glutamyl-taurine in different organisms (10). However, the physiological role of all the above mentioned peptides has so far remained entirely unknown in the case of the brain. We have therefore studied the effects of glutamyl-taurine and some synthetic analogs on the actions of putative neurotransmitter amino acids.


Glutamate Release Gaba Release Amino Acid Uptake Synaptic Membrane Excitatory Amino Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • V. Varga
    • 1
    • 2
  • Kirsi-Marja Marnela
    • 1
  • Pirjo Kontro
    • 1
  • J. Gulyás
    • 3
  • Z. Vadász
    • 2
  • P. Lähdesmäki
    • 4
  • S. S. Oja
    • 1
  1. 1.Department of Biomedical SciencesUniversity of TampereTampereFinland
  2. 2.Institute of Biochemistry, Department ISemmelweis University Medical SchoolBudapestHungary
  3. 3.Institute of Organic ChemistryEötvös Lóránd UniversityBudapestHungary
  4. 4.Department of BiochemistryUniversity of OuluOuluFinland

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