Interactions of Taurine and Dopamine in the Striatum

  • Pirjo Kontro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


The concentration of taurine in the striatum is high (23, 29). High-affinity taurine uptake has been demonstrated in striatal synaptosomes (5, 24), and selective uptake into a subpopulation of striatal neurons (4). Both the content and K+ -stimulated release of taurine are reduced after an intrastriatal injection of kainate, indicating a neuronal localization of the amino acid (25, 31). Although electrophysiological data on taurine in the striatum are scant, the above evidence suggests that taurine is involved in striatal functions. The striatum is particularly rich in dopaminergic neurons, rendering it possible that taurine could modulate dopaminergic transmission. Indeed, intraventricularly injected taurine increases the synthesis of dopamine in the rat brain and inhibits the firing of dopamine neurons (7). Intraventricular taurine also stimulates prolactin secretion, possibly via interaction with dopamine or serotonin transmitter systems (34), and unilateral intranigral injection of taurine induces a dose-dependent contralateral circling behavior which is partially blocked by haloperidol (12). I have now further elucidated the modulatory role of taurine in the function of striatal dopaminergic systems by studying mutual interactions of taurine and dopamine in release and uptake processes in the rat striatum. The effects of taurine on the binding of tritiated spiperone, a ligand for dopamine receptors, to striatal synaptic membranes was also investigated.


Dopamine Release Striatal Slice Taurine Release Taurine Uptake Striatal Membrane 
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  1. 1.
    Andersen, L., Sundman, L.-O., Linden, I.-B., Kontro, P., and Oja, S.S., 1984, Synthesis and anticonvulsant properties of some 2-amino-ethanesulphonic acid (taurine) derivatives, J. Pharm. Sci., 73: 106–108.PubMedCrossRefGoogle Scholar
  2. 2.
    Banay-Schwartz, M., Wajda, I.J., Manigault, I., DeGuzman, T., and Lajtha, A., 1982, Lithium: effect on [3H] spiperone binding, ionic content, and amino acid levels in the brain of rats, Neurochem. Res., 7: 179–189.PubMedCrossRefGoogle Scholar
  3. 3.
    Chesselet, M.-F., 1984, Presynaptic regulation of neurotransmitter release in the brain: facts and hypotheses. Neuroscience, 12: 347–375.PubMedCrossRefGoogle Scholar
  4. 4.
    Clarke, D.J., Smith, A.D., and Bolam, J.P., 1983, Uptake of [3H] taurine into medium-size neurons and into identified striatonigral neurons in the rat neostriatum, Brain Res., 289: 342–348.PubMedCrossRefGoogle Scholar
  5. 5.
    Collins, G.G.S., 1974, The rates of synthesis, uptake and disappearance of [14C] taurine in eight areas of the rat central nervous system, Brain Res., 76: 447–459.PubMedCrossRefGoogle Scholar
  6. 6.
    Dismukes, R.K., De Boer, A.A., and Mulder, A.H., 1977, The mechanism of alpha-receptor mediated modulation of [3H]noradrenaline release from slices of rat neocortex, Naunyn-Schmiedebergs Arch. Pharmac, 299: 115–122.CrossRefGoogle Scholar
  7. 7.
    Garcia de Yebenes Prous, J., Carlsson, A., and Mena Gomez, M.A., 1978, The effect of taurine on motor behaviour, body temperature and monoamine metabolism in rat brain, Naunyn-Schmiedebergs Arch. Pharmac, 304: 95–99.CrossRefGoogle Scholar
  8. 8.
    Girault, J.A., Barbeito, L., Spampinato, U., Gozlan, H., Glowinski, J., and Besson, M.-J., 1986, In vivo release of endogenous amino acids from the rat striatum: further evidence for a role of glutamate and aspartate in corticostriatal neurotransmission, J. Neurochem., 47: 98–106.PubMedCrossRefGoogle Scholar
  9. 9.
    Hancock, A.A., and Marsh, C.L., 1984, Distinctions between ligand-binding sites for [3H]dopamine and D2 dopaminergic receptors characterized with [3H]spiroperidol, Mol. Pharmac, 26: 439–451.Google Scholar
  10. 10.
    Howlett, D.R., and Nahorski, S.R., 1980, Quantitative assessment of heterogeneous [3H]spiperone binding to rat neostriatum and frontal cortex, Life Sci., 26: 511–517.PubMedCrossRefGoogle Scholar
  11. 11.
    Huff, R.A.M., and Molinoff, P.B., 1982, Quantitative determination of dopamine receptor subtypes not linked to activation of adenylate cyclase in rat striatum, Proc Natl Acad. Sci. USA, 79: 7562–7565.CrossRefGoogle Scholar
  12. 12.
    Kaakkola, S., and Kääriäinen, I., 1980, Contralateral circling behavior induced by intranigral injection of taurine in rats. Acta Pharmac. Toxic (Kbh), 46: 293–298.CrossRefGoogle Scholar
  13. 13.
    Kerwin, R., and Pycock, C., 1979, Effects of co-amino acids on tritiated dopamine release from rat striatum: evidence for a possible glycinergic mechanism, Biochem. Pharmac, 28: 2193–2197.CrossRefGoogle Scholar
  14. 14.
    Kontro, P., 1984, Comparison of taurine, hypotaurine and ß-alanine uptake in brain synaptosomal preparations from developing and adult mouse, Int. J. Dev. Neurose1., 2: 465–470.CrossRefGoogle Scholar
  15. 15.
    Kontro, P., and Oja, S.S., 1978, Taurine uptake by rat brain synaptoomes, J. Neurochem., 30: 1297–1304.PubMedCrossRefGoogle Scholar
  16. 16.
    Kontro, P., and Oja, S.S., 1984, Binding and uptake of taurine and GABA in developing and adult mouse brain, Acta Univ. Tamper. [B], 21: 60–67.Google Scholar
  17. 17.
    Kontro, P., and Oja, S.S., 1985, Properties of sodium-independent taurine binding to brain synaptic membranes, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro and M.K. Paasonen, eds. Alan R. Liss, New York, pp. 249–260.Google Scholar
  18. 18.
    Kontro, P., and Oja, S.S., 1986, Taurine interferes with spiperone binding in the striatum, Neuroscience, 19: 1007–1010.PubMedCrossRefGoogle Scholar
  19. 19.
    Kontro, P., and Oja, S.S., 1987, Taurine efflux from brain slices: potassium-evoked release is greater from immature than mature brain tissue, in this volume.Google Scholar
  20. 20.
    Kontro, P., and Oja, S.S., 1987, Taurine and GABA release from mouse cerebral cortex slices: effects of structural analogues and drugs, Neurochem. Res., 12: 475–482.PubMedCrossRefGoogle Scholar
  21. 21.
    Korpi, E.R., and Oja, S.S., 1979, Efflux of phenylalanine from rat cerebral cortex slices as influenced by extra-and intracellular amino acids, J. Neurochem., 32: 789–796.PubMedCrossRefGoogle Scholar
  22. 22.
    Korpi, E.R., and Oja, S.S., 1984, Comparison of two superfusion systems for study of neurotransmitter release from rat cerebral cortex slices, J. Neurochem., 43: 236–242.PubMedCrossRefGoogle Scholar
  23. 23.
    Lombardini, J.B., 1976, Regional and subcellular studies on taurine in the rat central nervous system, in: “Taurine”, R. Huxtable and A. Barbeau, eds., Raven Press, New York, pp. 311–326.Google Scholar
  24. 24.
    Lombardini, J.B., 1978, High-affinity transport of taurine in the mammalian central nervous system, in: “Taurine and Neurological Disorders”, A. Barbeau and R.J. Huxtable, eds., Raven Press, New York, pp. 119–135.Google Scholar
  25. 25.
    Nicklas, W.J., Duvoisin, R.C., and Berl, S., 1979, Amino acids in the rat neostriatum: alteration by kainic acid lesion, Brain Res., 167: 107–117.PubMedCrossRefGoogle Scholar
  26. 26.
    Nomura, Y., Oki, K., and Sewaga, T., 1982, Ontogenic development of the striatal [3H]spiperone binding: regulation by sodium and guanine nucleotide in rats, J. Neurochem., 38: 902–908.PubMedCrossRefGoogle Scholar
  27. 27.
    Oja, S.S., and Kontro, P., 1980, Hypotaurine uptake by brain slices from adult and 8-day-old mice, J. Neurochem., 35: 1303–1308.PubMedCrossRefGoogle Scholar
  28. 28.
    Oja, S.S., Kontro, P., and Lähdesmäki, P., 1977, Amino acids as inhibitory neurotransmitters, Prog. Pharmac, 1 (3): 1–119.Google Scholar
  29. 29.
    Perry, T.L., Sanders, H.D., Hansen, S., Lesk, D., Kloster, M., and Gravlin, L., 1972, Free amino acids and related compounds in five regions of biopsied cat brain, J. Neurochem., 19: 2651–2656.PubMedCrossRefGoogle Scholar
  30. 30.
    Pin, J.-P., Weiss, S., Sebben, M., Kemp, D.E., and Bockaert, J., 1986, Release of endogenous amino acids from striatal neurons in primary culture, J. Neurochem., 47: 594–603.PubMedCrossRefGoogle Scholar
  31. 31.
    Placheta, P., Singer, E., Schönbeck, G., Heckl, K., and Karobath, M., 1979, Reduction of endogenous level, uptake and release of taurine after intrastriatal kainic acid injection, Neuropharmacology, 18: 399–402.PubMedCrossRefGoogle Scholar
  32. 32.
    Pycock, C.J., and Smith, L.F.P., 1983, Interactions of dopamine and the release of [3H]-taurine and [3H]-glycine from the isolated retina of the rat, Br. J. Pharmac, 78: 395–404.CrossRefGoogle Scholar
  33. 33.
    Raiteri, M., Marchi, M., and Maura, G., 1984, Release of catecholamines, serotonin, and acetylcholine from isolated brain tissue, In: “Handbook of Neurochemistry, 2nd edn, vol. 6”, A. Lajtha, ed., Plenum Press, New York, pp. 431–462.CrossRefGoogle Scholar
  34. 34.
    Scheibel, J., Elsasser, T., and Ondo, J.G., 1980, Stimulation of prolactin secretion by taurine, a neurally depressant amino acid, Neuroendocrinology, 30: 350–354.PubMedCrossRefGoogle Scholar
  35. 35.
    Seeman, P., 1980, Brain dopamine receptors, Pharmac. Rev., 32: 229–313.Google Scholar
  36. 36.
    Sharp, T., Zetterström, T., and Ungerstedt, U., 1986, An in vivo study of dopamine release and metabolism in rat brain regions using intra-cerebral dialysis, J. Neurochem., 47: 113–122.PubMedCrossRefGoogle Scholar
  37. 37.
    Smith, L.F.P., and Pycock, C.J., 1982, Potassium-stimulated release of radiolabelled taurine and glycine from the isolated rat retina, J. Neurochem., 39: 653–658.PubMedCrossRefGoogle Scholar
  38. 38.
    Toivonen, M.-L., Linden, I.-B., and Vapaatalo, H., 1984, Effect of taltrimide on dopamine mediated behaviour. Abstracts of the Symposium Taurine: Biological Actions and Clinical Perspectives, p. 49, Hanasaari, Espoo.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Pirjo Kontro
    • 1
  1. 1.Department of Biomedical SciencesUniversity of TampereTampereFinland

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