Further Observation on the Interaction of Taurine and Calmodulin on the Central Adrenergic Neuron

  • Tomio Segawa
  • Yasuyuki Nomura
  • Ichiro Shimazaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


Taurine (2-aminoethanesulfonic acid) is present In the CNS in high concentration. Several findings support the hypothesis that taurine might act as an inhibitory transmitter or a modulator in CNS (1,3,9). Taurine decreases the depolarization-induced release of labelled norepinephrine and acetylcholine from rat cerebral cortex, possibly by increasing retention of Ca2+ within mitochondria (5). Similarly, taurine reduced the release of [3H]GABA from guinea pig cerebellar slices by reducing the availability of Ca2+ (8).


Kainic Acid Norepinephrine Release Adrenergic Neuron Taurine Uptake Equilibrium Binding Study 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Tomio Segawa
    • 1
  • Yasuyuki Nomura
    • 1
  • Ichiro Shimazaki
    • 1
  1. 1.Department of Pharmacology, Institute of Pharmaceutical SciencesHiroshima University School of MedicineHiroshima 734Japan

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