Advertisement

Further Observation on the Interaction of Taurine and Calmodulin on the Central Adrenergic Neuron

  • Tomio Segawa
  • Yasuyuki Nomura
  • Ichiro Shimazaki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

Taurine (2-aminoethanesulfonic acid) is present In the CNS in high concentration. Several findings support the hypothesis that taurine might act as an inhibitory transmitter or a modulator in CNS (1,3,9). Taurine decreases the depolarization-induced release of labelled norepinephrine and acetylcholine from rat cerebral cortex, possibly by increasing retention of Ca2+ within mitochondria (5). Similarly, taurine reduced the release of [3H]GABA from guinea pig cerebellar slices by reducing the availability of Ca2+ (8).

Keywords

Kainic Acid Norepinephrine Release Adrenergic Neuron Taurine Uptake Equilibrium Binding Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barbeau, A., Inoue, N., Tsukada, Y., and Butterworth, R.F., 1975, The neuropharmacology of taurine, Life Sci., 17:669–678.PubMedCrossRefGoogle Scholar
  2. 2.
    Crouch, T.H., and Klee, C.B., 1980, Positive cooperative binding of calcium to bovine brain calmodulin, Biochemistry, 19:3692–3698.PubMedCrossRefGoogle Scholar
  3. 3.
    Davidson, A.N., and Kaczmarek, L.K., 1971, Taurine, a possible neurotransmitter, Nature, 234:107–108.CrossRefGoogle Scholar
  4. 4.
    Klee, C.B., 1977, Conformational transition accompanying the binding of Ca2+ to the protein activator of 3′, 5′-cyclic adenosine monophosphate phosphodiesterase, Biochemistry, 16:1017–1024.PubMedCrossRefGoogle Scholar
  5. 5.
    Kuriyama, K., Muramatsu, M., Nakazawa, K., and Kakita, K., 1978, Modulating role of taurine on release of neurotransmitter and calcium transport in excitable tissues, in: “Taurine and Neurological Disorders”, A. Barbeau and R. J. Huxtable eds., Raven Press, New York, pp. 201–216.Google Scholar
  6. 6.
    Mendelson, W.B., Skolnich, P., Martion, J.J., Lun, M.D., Wagner, R., and Paul, S.M. 1984, Diazepam-stimulated increases in the synaptosomal uptake of 45Ca2+: Reversal by dihydropyridine calcium channel antagonists, Eur. J. Pharmacol., 104:181–183.PubMedCrossRefGoogle Scholar
  7. 7.
    Miura, Y., Nomura, Y., and Segawa, T., 1982, Interaction of taurine with γ-adrenergic receptors in rat central nervous system, Sulfur Amino Acids, 5:77–86.Google Scholar
  8. 8.
    Namina, M., Okamoto, K., and Sakai, Y., 1983, Modulatory action of taurine on the release of GABA in cerebellar slices of the guinea-pig, J. Neurochem., 40:1–9.CrossRefGoogle Scholar
  9. 9.
    Okamoto, K., and Sakai, Y., 1980, Localization of sensitive sites to taurine, γ-aminobutyric acid, glycine and β-alanine in the molecular layer of guinea-pig cerebellar slices, Brit. J. Pharmac., 69:407–413.CrossRefGoogle Scholar
  10. 10.
    Schaffer, S.W., Kramer, J.H., Lampson, W.G., Kulakowski, E., and Sakane, Y., 1983, Effect of taurine on myocardial metabolism: Role of calmodulin, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, K. Kuriyama, R.J. Huxtable and H. Iwata eds., Alan R. Liss, Inc., New York, pp. 39–50.Google Scholar
  11. 11.
    Segawa, T., Nomura, Y., and Shimazakl, I., 1985, Possible involvement of calmodulin in modulatory role of taurine in rat cerebral β-adrenergic neurons, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro and M.K. Paasonen eds., Alan R. Liss, Inc., New York, pp. 321–330.Google Scholar
  12. 12.
    Shimazaki, I., Nomura, Y., and Segawa, T., 1984, Interaction of taurine and calmodulin on adrenergic neuron in rat brain, Sulfur Amino Acids, 7:25–31.Google Scholar
  13. 13.
    Simon, J.R., Contrera, J.F., and M.J. Kuhar, 1976, Binding of [3H]kainic acid, an analogue of L-glutamate, to brain membranes, J. Neurochem., 36:141–147.Google Scholar
  14. 14.
    Yazawa, M., Kuwayama, H., and Yagi, K., 1978, Molecular protein as a Ca2+-dependent activator of rabbit skeletal myosine light-chain kinase, J. Biochem., 84:1253–1258.PubMedGoogle Scholar
  15. 15.
    Yazawa, M., Sakuma, M., and Yagi, K., 1980, Calmodulins from muscles of marine invertebrates, scallop and sea anemone, J. Biochem., 87:1313–1320.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Tomio Segawa
    • 1
  • Yasuyuki Nomura
    • 1
  • Ichiro Shimazaki
    • 1
  1. 1.Department of Pharmacology, Institute of Pharmaceutical SciencesHiroshima University School of MedicineHiroshima 734Japan

Personalised recommendations