Further Observation on the Interaction of Taurine and Calmodulin on the Central Adrenergic Neuron

  • Tomio Segawa
  • Yasuyuki Nomura
  • Ichiro Shimazaki
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

Taurine (2-aminoethanesulfonic acid) is present In the CNS in high concentration. Several findings support the hypothesis that taurine might act as an inhibitory transmitter or a modulator in CNS (1,3,9). Taurine decreases the depolarization-induced release of labelled norepinephrine and acetylcholine from rat cerebral cortex, possibly by increasing retention of Ca2+ within mitochondria (5). Similarly, taurine reduced the release of [3H]GABA from guinea pig cerebellar slices by reducing the availability of Ca2+ (8).

Keywords

Kainic Acid Norepinephrine Release Adrenergic Neuron Taurine Uptake Equilibrium Binding Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Tomio Segawa
    • 1
  • Yasuyuki Nomura
    • 1
  • Ichiro Shimazaki
    • 1
  1. 1.Department of Pharmacology, Institute of Pharmaceutical SciencesHiroshima University School of MedicineHiroshima 734Japan

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