The Effect of Taurine on Excitatory Receptor Binding in Rat Hippocampal Membranes
Recent reports have shown that L-3H glutamate binds with high affinity to hippocampal membranes (12). Moreover, this binding is increased by CaCl2 (1), although it is still under discussion whether the calcium increase is mediated by chloride ions (11,16). Many authors suggest that Ca2+ can activate neutral protease (2) and that the activity of these proteases could be responsible for learning and memory capability (10). Taurine is a molecule that is able to reduce L-glutamate-induced depolarization in isolated frog spinal cord (7) and to abolish the after-hyperpolarization induced by L-glutamate (8). Moreover, it reduces acquisition of avoidance conditioned reflex (14) and decreases acquisition and, to a lesser extent, retention of a step-down passive avoidance task (13). In the nervous system, taurine interacts with calcium. In fact, 25 mM taurine increases the high affinity Ca2+ binding to rat hippocampal membranes but has no effect on low affinity Ca2+ uptake to rat brain synaptosomes (6).
KeywordsNeutral Protease Scatchard Analysis Cold Distil Water Preincubation Period Frog Spinal Cord
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