The Biology of Taurine pp 237-244 | Cite as
Possible Involvement of Brain Calcium Metabolism in the Action of Taurine in Mammalian Thermoregulation
Chapter
Abstract
Much attention in the last few years has been devoted to the clarification of the possible role of taurine in thermoregulation. One of the most striking and consistent effects of central (icv) administration of taurine in mammals is hypothermia. The primary action of taurine on thermoregulatory effectors is expressed peripherally mainly by the promotion of heat dissipation which takes place through a reduction in peripheral vasomotor tone particularly evident in rabbits at the ear vascular bed (22) and by the inhibition of shivering, as shown in primates (11). The participation of the central serotonin system in mediating, at least in part, the taurine effect on thermoregulation has also been demonstrated (22). This serotonergic component is probably responsible for a decrease in metabolic heat production and for an increase in the evaporative heat loss (9) which also accompany taurine-induced hypothermia in the sheep (1). In addition, structure-action correlation studies (21,23) performed on a number of amino-acid compounds structurally related to taurine suggested the existence of two inhibitory synaptic mechanisms, one taurine- and the other GABA-mediated, centrally acting on thermoregulatory effectors by working either independently or synergistically.
Keywords
Evaporative Heat Loss Thermoregulatory Effector Single Rabbit Affect Body Temperature Cerebrospina1 Fluid
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References
- 1.Bligh, J., Silver, A., Smith, C.A., and Bacon, M.J., 1979, The effects on thermoregulation in the sheep of intracerebroventricular injection of taurine, glycine, GABA and muscimol, J. Therm. Biol., 4:9–14.CrossRefGoogle Scholar
- 2.Bolger, G.T., Weissman, B.A., and Skolnick, P., 1985, The behavioral effects of the calcium agonist Bay-K-8644 in the mouse: Antagonism by the calcium antagonists nifedipine, Naunyn-Schmiedeberg’s Arch. Pharmacol., 328:373–377.CrossRefGoogle Scholar
- 3.Cooper, K.E., and Veale, W.L., 1973, Exchange between the blood-brain and cerebrospinal fluid of substances which can induce or modify febrile responses. in: “The pharmacology of thermo-regulation”, E. Schonbaum and P. Lomax, eds., S. Karger, Basel, pp. 278–288.Google Scholar
- 4.Feldberg, W., Myers, R.D., and Veale, W.L., 1970, Perfusion from cerebral ventricle to cisterna magna in the unanaesthetized cat. Effect of calcium on body temperature, J. Physiol. (London), 207: 403–416.Google Scholar
- 5.Fleckenstein, A., 1968, Experimental heart failure due to disturbances in high-energy phosphate metabolism, Proc. Vth Eur. Cong. Cardiol, Athens, pp. 255–269.Google Scholar
- 6.Fleckenstein, A., Tritthart, H., Doring, H.J., Byron, Y. K., 1972, Bay-a-1040 ein hochaktiver Ca++-antagonistischer inhibitor der elecktro-mechanischer Koppelungsprozesse im warmbluter-myokard, Arzneim Forsch., 22:22–23.Google Scholar
- 7.Girard, Y., Atkinson, J.G., Williams, M., Haubrich, D.R., and Yarbrough, G.G., 1982, Aminomethyl-l,2,4-benzothiadiazines as potent analogues of γ-aminobutyric acid. Unexpected discovery of a taurine antagonist, J. Med. Chem., 25:113–116.PubMedCrossRefGoogle Scholar
- 8.Greenleaf, J.E., 1978, Thresholds for Na+ and Ca++ effects on thermoregulation, in: “Effectors of thermogenesis”, L. Girardier and J. Seydoux, eds., Birkauser Verlag, Basel, pp. 33–43.Google Scholar
- 9.Lin, M.T., Pang, I.H., Chern, S.I., and Chia, W.Y., 1978, Changes in serotonin contents in brain effect metabolic heat production of rabbit in cold, Am. J. Physlol., 235:R41–R47.Google Scholar
- 10.Lipton, J.M., and Ticknor, C.B., 1979, Central effect of taurine and its analogues on fever caused by intravenous leukocytic pyrogen in the rabbit, J. Physiol. (London), 287:535–543.Google Scholar
- 11.Murphy, M.T., Lipton, J.M., Longhran, P., and Giesecke, A.H., 1985, Postanesthetic shivering in primates: Inhibition “by peripheral heating and by taurine, Anesthesiology, 63:161–165.PubMedCrossRefGoogle Scholar
- 12.Myers, R.D., and Veale, W.L., 1971, The role of sodium and calicum ions in the hypothalamus in the control of body temperature of the unanaesthetized cat, J. Physlol. (London), 212:411–430.Google Scholar
- 13.Myers, R.D., Veale, W.L., and Yaksh, T.L., 1971, Changes in body temperature of the unanaesthetized monkey produced by sodium and calcium ions perfused through the cerebral ventricles, J. Physlol. (London), 217:381–392.Google Scholar
- 14.Nielsen, B., 1974, Actions of intravenous Ca2+ and Na+ on body temperature in rabbits, Acta Physiol. Scand., 90:445–450.PubMedCrossRefGoogle Scholar
- 15.Nielsen, B., Schwartz, P., and Alhede, J., 1973, Is fever in man reflected in changes in cerebrospinal fluid concentrations of sodium and calcium ions?, Scand. J. Clin. Lab. Invest., 32:309–310.PubMedCrossRefGoogle Scholar
- 16.Okamoto, K., Kimura, H., and Sakai, Y., 1983, Antagonistic action of 6-aminomethyl-3-methyl-4H,1,2,4-benzothiadiazine-1,1-dioxide (TAG), and evidence for a transmitter role of taurine in stellate interneurons in the cerebellum, in: “Sulfur aminoacids: Biochemical and clinical’ aspects”, K. Kuriyama, R.J. Huxtable and H. Iwata eds., Alan R. Liss, Inc., New York, pp. 151–160.Google Scholar
- 17.Oppelt, W.W., Owens, E.S. and Rall, D.P., 1963, Calcium exchange between blood and cerebrospinal fluid, Life Sci., 8:599–605.PubMedCrossRefGoogle Scholar
- 18.Palmi, M., and Sgaragli, G.P. 1985, Hyperthermia induced in rabbits by AMBD and organic calcium antagonists: its reversal by taurine, Br. J. Pharmac, 86:693P.CrossRefGoogle Scholar
- 19.Schramm, M., Thomas, G., Towar, R., and Franckowiak, G., 1983, Novel dilydropyridines with positive inotropic action through activation of Ca++ channels, Nature (London), 303:535–537.CrossRefGoogle Scholar
- 20.Scopes, R.K., 1982, Solutions for measuring protein concentration, in: “Protein purification. Principles and practice”, Springer Verlag, New York, pp. 265–266.Google Scholar
- 21.Saragli, G.P., Carla, V., Magnani, M., and Giotti, A., 1978, Homotaurine and muscimol mimic taurine and GABA effects on muscle tone and temperature regulation, Naunyn-Schmiedeberg’s Arch. Pharmacol., 305:155–158.CrossRefGoogle Scholar
- 22.Sgaragli, G.P., Carla, V. Magnani, M., and Galli, A., 1981, Hypothermia induced in rabbits by intracerebroventricular taurine: Specificity and relationship with central serotonin (5-HT) systems, J. Pharmacol. Exp. Ther., 219:778–785.PubMedGoogle Scholar
- 23.Sgaragli, G.P., and Palmi, M., 1985, The role and mechanisms of action of taurine in mammalian thermoregulation. in: “Taurine: Biological actions and clinical perspectives”, S.S. Oja, L. Ahtee, P. Kontro and M.K. Paasonen, eds., Alan R. Liss, Inc., New York, pp. 343–357.Google Scholar
- 24.Spedding, M., 1982, Assessment of Ca2+-antagonist effects of drugs in K+-depolarized smooth muscle. Differentiation of antagonist subgroups, Naunyn-Schmiedeberg’s Arch. Pharmacol., 318:234–340.CrossRefGoogle Scholar
- 25.Stem, J., and Lewis, W.H.P., 1957, The colorimetric estimations of calcium in serum with O-cresolphthalein complexone, Clin. Chim. Acta, 2:576–582.CrossRefGoogle Scholar
- 26.Veale, W.L., and Myers, R.D., 1971, Emotional behavior, arousal and sleep produced by sodium and calcium ions perfused within the hypothalamus of the cat, Physiol. Behav., 7:601–607.PubMedCrossRefGoogle Scholar
- 27.Yarbrough, G.G., Singh, D.K., and Taylor, D.A., 1981, Neuropharmacological characterization of a taurine antagonist, J. Pharmacol. Exp. Ther., 219:604–613.PubMedGoogle Scholar
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© Springer Science+Business Media New York 1987