Taurine Inhibits Wet-Dog Shakes and Hippocampal Seizures Induced by Opioid Peptides in Rats
Wet dog shakes (WDS) are paroxysmal shudders of head, neck and trunk. This behavior has been observed when dipping animals into cold water (41), application of xylene to the für (39) and tactile stimulation around ears (1). Pharmacological studies revealed that WDS can be produced by administration of thyrotropin-releasing hormone (9,24,29,41,42), 5-Hydroxytryptamine (3,12), or kainic acid (5,25). WDS are also known as a classical sign of morphine abstinence in rats (40,43). In 1976, Bloom et al. first reported that this shaking behavior was elicited by acute administration of β-endorphln into the lateral ventricle in rats. Similar observations were made in rats with enkephalin (15). In addition, it was found that epileptic discharges were provoked by the intraventricular (icv) injection of opioid peptides and WDS always accompanied the onset of seizure discharges (15,16,37). These findings suggest that there may be an association between electrical seizure activities and WDS.
KeywordsSeizure Activity Opioid Peptide Aminobutyric Acid Intraventricular Injection Seizure Discharge
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