Insulin-Like Activity of Taurine

  • Joseph MaturoIII
  • Elliott C. Kulakowski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


There is now an increasing body of data that taurine (2-aminoethanesulfonic acid) at pharmacological concentrations alters carbohydrate metabolism. Early reports from Ackerman and Heinsen (1) and Macallum and Sivertz (10) found that taurine was potent a hypoglycemic agent. Several teams of investigators have confirmed these initial results. Donadio and Fromageot (4) confirmed the hypoglycemic properties of taurine and presented evidence that taurine increased glucose utilization in the rat diaphragm. Lampson et al. (9) reported that taurine was capable of enhancing the effects of insulin on cardiac glycolysis, glycogenesis and oxygen consumption. Moreover, when fasting rats were given a bolus injection of glucose, Kulakowski and Maturo (6) observed that taurine alone was capable of reducing serum glucose levels while stimulating 3-0-methylglucose uptake in skeletal muscle and liver, and glycogenesis in the liver. This occurred without a concomitant increase in serum insulin levels.


Insulin Receptor Krebs Ringer Bicarbonate Buffer Increase Glucose Utilization Proline Uptake Glycogen Production 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Joseph MaturoIII
    • 1
  • Elliott C. Kulakowski
    • 2
  1. 1.Biology DepartmentC. W. Post CollegeP.O. GreenvaleUSA
  2. 2.Hypertension Endocrine BranchNational Heart, Lung and Blood Institute, National Institutes of HealthBethesdaUSA

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