Advertisement

Insulin-Like Activity of Taurine

  • Joseph MaturoIII
  • Elliott C. Kulakowski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

There is now an increasing body of data that taurine (2-aminoethanesulfonic acid) at pharmacological concentrations alters carbohydrate metabolism. Early reports from Ackerman and Heinsen (1) and Macallum and Sivertz (10) found that taurine was potent a hypoglycemic agent. Several teams of investigators have confirmed these initial results. Donadio and Fromageot (4) confirmed the hypoglycemic properties of taurine and presented evidence that taurine increased glucose utilization in the rat diaphragm. Lampson et al. (9) reported that taurine was capable of enhancing the effects of insulin on cardiac glycolysis, glycogenesis and oxygen consumption. Moreover, when fasting rats were given a bolus injection of glucose, Kulakowski and Maturo (6) observed that taurine alone was capable of reducing serum glucose levels while stimulating 3-0-methylglucose uptake in skeletal muscle and liver, and glycogenesis in the liver. This occurred without a concomitant increase in serum insulin levels.

Keywords

Insulin Receptor Krebs Ringer Bicarbonate Buffer Increase Glucose Utilization Proline Uptake Glycogen Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ackerman, D., and Heinsen, H. A., 1935, Uber die physiologische Wirkung des asterubins und anderer, zum tiel neu dargestellter, schwefelhaltiger guanidinderivate, Z. Physiol. Chem., 235:115–121.CrossRefGoogle Scholar
  2. 2.
    Cauatrecasas, P., 1972, Isolation of the insulin receptor of liver and fat cell membranes, Proc. Nat. Acad. Sci. U.S.A., 69:318–322.CrossRefGoogle Scholar
  3. 3.
    Dokshina, G.A., Silaeva, T.Y., and Yartsev, E.I., 1976, Some insulin-like effects of taurine, Vopr. Med. Khim., 22:503–507.PubMedGoogle Scholar
  4. 4.
    Donadio, G., and Fromageot, P., 1964, Influence exercise par la tauri’ne sur l’utilisation du glucose par le rat, Bull. Soc. Chim. Bio!., 46:293–302.Google Scholar
  5. 5.
    Kulakowski, E.C., Maturo, J., and Schaffer, S.W., 1978, Identification of Taurine Receptors from Rat Heart Sarcolemma, Biochem. Biophys. Res. Common., 80:936–941.CrossRefGoogle Scholar
  6. 6.
    Kulakowski, E.C. and Maturo, J., 1984, Hypoglycemic properties of taurine: not mediated by enhanced insulin release. Biochem Pharmacol., 33:2835–2838.PubMedCrossRefGoogle Scholar
  7. 7.
    Kulakowski, E.C, Maturo, J., and Schaffer, S.W., 1985, The low affinity taurine-binding protein may be related to the insulin receptor in Taurine: Biological Actions and Clinical Perspectives, eds. Oja, S.S., Ahtee, L., Kontro, P., and Paasonen, M.K., Allan R. Lis, Inc., New York, 127–136.Google Scholar
  8. 8.
    Laborit, H., and Thuret., F., 1974, Action de la taurine sur certaines activities metaboliques, Agressologie., 15: 183–186.PubMedGoogle Scholar
  9. 9.
    Lampson, W.G., Kramer, J.H., and Schaffer, S.W., 1983, Potentiation of the actions of insulin by taurine, Can. J. Physioi. Pharmcol., 61:457–463.CrossRefGoogle Scholar
  10. 10.
    Macallum, A.B., and Sivertz, C, 1942, The potentiation of insulin by sulfones, Can. Chem. Process., 26:669.Google Scholar
  11. 11.
    Maturo, J.M., III, Siegel, G. and Furino, C. (1975) Studies on the effect of 2-hydroxy-5-nitroenzyl bromide on the mechanism of insulin. Life Science 16:415–422.CrossRefGoogle Scholar
  12. 12.
    Maturo, J.M., Hollenberg, M.D., and Aglio, L.S., 1983, Insulin receptor: Insulin-modulated interconversion between distinct molecular forms involving disulfide-sulfhydryl exchange, Biochem., 22:2579–2586.CrossRefGoogle Scholar
  13. 13.
    Nakagawa, K., and Kuriyama, K., 1975, Effect of taurine on alteration in adrenal functions induced by stress, Jap. J. Pharmacol., 25:737–746.PubMedCrossRefGoogle Scholar
  14. 14.
    Reibel, D.K., Shaffer, J.E., Kocsis, J.J., and Neely, J.R., 1979, Changes in taurine content in heart and other organs of diabetic rats, J. Mol. Cell. Cardiol., 11:827–830.PubMedCrossRefGoogle Scholar
  15. 15.
    Rieser, P., and Maturo, J., 1969, Insulin, substrate transport, and protein synthesis in muscle, Arch. Int. Med., 123:267–271.CrossRefGoogle Scholar
  16. 16.
    Rodbell, M., 1964, Metabolism of isolated fat cells, J. Biol. Chem. 239:375–380.PubMedGoogle Scholar
  17. 17.
    Shimuza, T., Shimizu, S., Nagami, S., and Wada, M., 1960, Effect of hypo, taurine and cysteine on alloxan-and dehydroxyascorbic acid-diabetes, Niigata Med. J., 74:931–939.Google Scholar
  18. 18.
    Silaeva, T.Y., Dokshina, G.A., Yartsev, E.I., Yakoleva, V.V. and Arkhangelskaya, T.E., 1976, The effect of taurine on the carbohydrate metabolism of diabetic animals, Prob. Endokrinol., 22:99–103.Google Scholar
  19. 19.
    Tokuwaga, H., Yoneda, Y., and Kuriyama, K., (1979) Protective actions of taurine against streptozotocin-induced hyperglycemia, Biochem. Pharmacol., 28:2807–2811 (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Joseph MaturoIII
    • 1
  • Elliott C. Kulakowski
    • 2
  1. 1.Biology DepartmentC. W. Post CollegeP.O. GreenvaleUSA
  2. 2.Hypertension Endocrine BranchNational Heart, Lung and Blood Institute, National Institutes of HealthBethesdaUSA

Personalised recommendations