An Analysis of the Effects of Taurine on Cellular and Extracellular Calcium Mobilization in Rabbit Ear Artery

  • Stefano Manzini
  • Adriana Castellucci
  • Flavia Franconi
  • Alberto Giotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


Tonic vasoconstriction of rabbit ear artery depends mainly upon influx of extracellular Ca++ through plasmalemmal calcium channels activated by depolarization (voltage-operated channel) or by stimulation of specific receptors (receptor operated channel) (4,5,16,17,19). Taurine has been shown to be an effective antagonist of depolarization- but not norepinephrine-induced tonic vasoconstrictions in rabbit ear artery (8,9), suggesting a selective interference on the availability of the voltage operated channel. However, in vascular smooth muscle other sources of calcium are involved in excitation-contraction coupling; for example release of calcium from internal store such as sarcoplasmic reticulum (4).


Free Medium Free Solution Perfusion Fluid Physiological Salt Solution Calcium Entry Blocker 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Stefano Manzini
    • 1
  • Adriana Castellucci
  • Flavia Franconi
    • 2
  • Alberto Giotti
    • 3
  1. 1.Pharmacology DepartmentMalesci S.p.A. — Instituto FarmacobiologicoFirenzeItaly
  2. 2.Faculty of PharmacyUniversity of SassariSassariItaly
  3. 3.Pharmacology DepartmentUniversity of FlorenceFirenzeItaly

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