An Analysis of the Effects of Taurine on Cellular and Extracellular Calcium Mobilization in Rabbit Ear Artery

  • Stefano Manzini
  • Adriana Castellucci
  • Flavia Franconi
  • Alberto Giotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

Tonic vasoconstriction of rabbit ear artery depends mainly upon influx of extracellular Ca++ through plasmalemmal calcium channels activated by depolarization (voltage-operated channel) or by stimulation of specific receptors (receptor operated channel) (4,5,16,17,19). Taurine has been shown to be an effective antagonist of depolarization- but not norepinephrine-induced tonic vasoconstrictions in rabbit ear artery (8,9), suggesting a selective interference on the availability of the voltage operated channel. However, in vascular smooth muscle other sources of calcium are involved in excitation-contraction coupling; for example release of calcium from internal store such as sarcoplasmic reticulum (4).

Keywords

Free Medium Free Solution Perfusion Fluid Physiological Salt Solution Calcium Entry Blocker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arzate, M.E., Ponce, H., and Pasantes-Morales, H., 1984, Antagonistic effects of taurine and 4-aminopyridine on guinea pig ileum, J. Neurosci. Res., 11:271–280.PubMedCrossRefGoogle Scholar
  2. 2.
    Becattini, U., 1967, Prospettive di un nuovo farmaco nella terapia delle vasculopatie: la taurina, Sett. Med., 55:1255–1265.Google Scholar
  3. 3.
    Bevan, J.A., Garstka, W., Su, G., and Su, M.O., 1973, The biomodal basis of the contractile response of the rabbit ear artery to norepinephrine and other agonists, Eur. J. Pharmacol., 22:47–53.PubMedCrossRefGoogle Scholar
  4. 4.
    Bolton, T.B., 1979, Mechanisms of action of transmitters and other substances on smooth muscle, Physiol. Rev., 59:606.PubMedGoogle Scholar
  5. 5.
    Casteel, R., 1980, Electro-and Pharmacomechanical coupling in vascular smooth muscle, Chest, 78:150–156.Google Scholar
  6. 6.
    Deth, R.C., and Lynch, C.J., 1981, Mobilization of a common source of smooth muscle calcium ions by NE and methylxanthines, Am. J. Physiol., 240 (Cell Physiol. 9): C239–C247.PubMedGoogle Scholar
  7. 7.
    Flaim, S.F., and Di Fette, D.J., 1979, Digoxin-norepinephrine response and calcium blocker effects on vascular smooth muscle, Am. J. Physiol., 236:H613–H619.PubMedGoogle Scholar
  8. 8.
    Franconi, F., Giotti, A., Manzini, S., Martini, F., Stendardi, I., and Zilletti, L., 1982, The effect of taurine on high potassium-and noradrenaline-induced contraction in rabbit ear artery, Br. J. Pharmac, 75: 605–612.CrossRefGoogle Scholar
  9. 9.
    Franconi, F., Manzini, S., Stendardi, I., Bennardini, F., Antonini, G., Failli, P., Matucci, R., and Giotti, A., 1983, Differential inhibitory effect of taurine on contractile responses to potassium an noadrenaline in rabbit ear artery, J. Pharm. Pharmacol., 35:46–48.PubMedCrossRefGoogle Scholar
  10. 10.
    Glossmann, H., Ferry, D.R., Lubbecke, F., Mewes, R., and Hofmann, F., 1983, Identification of voltage operated calcium channels by binding studies: differentiation of subclasses of calcium antagonist drugs with 3H-nimodipine radioligand binding, J. Receptor Res., 3(1&2):177–190.Google Scholar
  11. 11.
    Gruener, R., Markovitz, D., Huxtable, R., and Bressler, R., 1975, Excitability modulation by taurine: transmembrane measurement of neuromuscular transmission, J. Neurol. Sci., 24:351–360.PubMedCrossRefGoogle Scholar
  12. 12.
    Hudgins, P.M., and Weiss, G.B., 1968, Differential effects of Ca2+ removal upon vascular smooth muscle contraction induced by norepinephrine histamine and potassium, J. Pharmacol. Expt. Ther., 159:91–97.Google Scholar
  13. 13.
    Kolhardt, M., and Flecknstein, A., 1977, Inhibition of the slow inward current by nifedipine in mammalian ventricular myocardium, Naunyn-Schmed. Arch. Pharmacol., 298:267–272.CrossRefGoogle Scholar
  14. 14.
    Leander, S., Arner, A., and Johansson, B., 1977, Effects of 4-amino-pyridine on mechanical activity and noradrnaline release in the rat portal vein in vitro, Eur. J. Pharmacol., 46:351–361.PubMedCrossRefGoogle Scholar
  15. 15.
    Maggi, CA., Manzini. S., and Meli, A., 1983, Contribution of cellular and extracellular Ca2+ during 5-hydroxytryptamine-induced contractions of rabbit ear artery, Eur. J. Pharmacol., 94:251–260.PubMedCrossRefGoogle Scholar
  16. 16.
    Maggi, C.A., Manzini, S., and Meli, A., 1984, Differential effects of vasodilators on the mobilization of calcium pools during contractions of rabbit ear artery induced by norepinephrine and high potassium, J. Pharm. Pharmacol., 36:27–30.PubMedCrossRefGoogle Scholar
  17. 17.
    Manzini, S., Maggi, C.A., and Meli, A., 1982, A simplex procedure for. assessing norepinephrine induced cellular and extracellular calcium ions mobilization in rabbit ear artery, J. Pharmacol. Methods, 8:47–57.PubMedCrossRefGoogle Scholar
  18. 18.
    Manzini, S., Maggi, C.A., and Meli, A., 1982, Aminophylline-induced contractions of rabbit ear artery in high-K+ Ca2+-free medium, J. Pharm. Pharmacol., 34:195–196.PubMedCrossRefGoogle Scholar
  19. 19.
    Manzini, S., Maggi, CA., and Meli, A., 1983, Alpha-adrenoceptors subtypes and Ca2+-mobilization in the rabbit ear artery, J. Pharm. Pharmacol., 35:584–589.PubMedCrossRefGoogle Scholar
  20. 20.
    Manzini, S., Maggi, C.A., and Meli, A., 1986, 5-hydroxytryptamine delays relaxation time of norepinephrine-induced vasoconstriction, Am. J. Physiol., 250 (Heart Circ. Physiol. 19):H121–H130.PubMedGoogle Scholar
  21. 21.
    Nara, Y., Yamori, Y., and Lovenberg, W., 1978, Effect of dietary taurine on blood pressure in spontaneously hypertensive rats, Biochem. Pharmac, 77:2689–2692.Google Scholar
  22. 22.
    Saida, K., and Van Breemen, C, 1984, Characteristics of the norepinephrine sensitive Ca2+ stores in vascular smooth muscle, Blood Vessels, 21:43–52.PubMedGoogle Scholar
  23. 23.
    Schaffer, S.W., and Kocsls, J.J., 1979, Taurine: research surges after 150 years, Am. Pharm., 19:652–654.Google Scholar
  24. 24.
    Steinsland, O.S., Furchgott, R.F., and Kirpekar, S.M., 1973, Biphasic vasoconstriction of the rabbit ear artery, Circ. Res., 32:49–58.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Stefano Manzini
    • 1
  • Adriana Castellucci
  • Flavia Franconi
    • 2
  • Alberto Giotti
    • 3
  1. 1.Pharmacology DepartmentMalesci S.p.A. — Instituto FarmacobiologicoFirenzeItaly
  2. 2.Faculty of PharmacyUniversity of SassariSassariItaly
  3. 3.Pharmacology DepartmentUniversity of FlorenceFirenzeItaly

Personalised recommendations