Calcium Overload-Induced Myocardial Damage Caused by Isoproterenol and by Adriamycin: Possible Role of Taurine in its Prevention

  • Junichi Azuma
  • Tomoyuki Hamaguchi
  • Hideyuki Ohta
  • Keiko Takihara
  • Nobuhisa Awata
  • Akihiko Sawamura
  • Hisato Harada
  • Yuya Tanaka
  • Susumu Kishimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


Calcium ion (Ca2+) is essential for excitation-contraction coupling and for maintenance of cell integrity in the myocardium. On the other hand, it is clear that cytosolic Ca2+ loading may be the first event leading to cell death in certain forms of myocytic injury, such as Ca2+ paradox and isoproterenol (ISO) toxicity. The Ca2+ overload injury is characterized by an exhaustion of tissue high-energy phosphate, massive release of enzymes and extensive ultrastructural damage, as well as excessive influx of Ca2+ into the myocardial cells.


Taurine Transport Taurine Content Taurine Treatment Cardiomyopathic Hamster Taurine Administration 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Junichi Azuma
    • 1
  • Tomoyuki Hamaguchi
    • 1
  • Hideyuki Ohta
    • 1
  • Keiko Takihara
    • 1
  • Nobuhisa Awata
    • 1
  • Akihiko Sawamura
    • 1
  • Hisato Harada
    • 1
  • Yuya Tanaka
    • 1
  • Susumu Kishimoto
    • 1
  1. 1.The Third Department of Internal MedicineOsaka University Medical School1-1-50 Fukushima, Osaka 533Japan

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