Potentiation of Myocardial Ischemic Injury by Drug-Induced Taurine Depletion

  • S. W. Schaffer
  • S. Allo
  • M. Mozaffari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


The discovery that taurine treatment reverses arrhythmias associated with epinephrine- and digoxin-induced toxicity stimulated research into the myocardial actions of taurine and eventually led to the hypothesis that taurine must have an important physiological function in the heart (10,14, 25,28). Two subsequent lines of evidence have provided the most compelling support for this hypothesis. First, cardiac taurine levels are extremely high and are maintained by an energy-dependent transport process (14,29). Second, exposure of the heart to a medium containing taurine results in a significant change in myocardial energy and calcium metabolism (5–7,15, 18,20,28).


Taurine Level Taurine Transport Taurine Content Myocardial Ischemic Injury Taurine Treatment 
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  1. 1.
    Azari, J., Brumbaugh, P., and Huxtable, R.J., 1980, Prophylaxis by taurine in the hearts of cardiomyopathic hamsters, J. Mol. Cell. Cardiol., 12:1353–1366.PubMedCrossRefGoogle Scholar
  2. 2.
    Azuma, J., Sawamura, A., Awata, N., Hasegawa, H., Ogura, K., Harada, H., Ohata, H., Yamauchi, K., Kishimoto, S., Yamagami, T., Ueda, E., and Ishiyama, T., 1983, Double blind randomized crossover trial of taurine in congestive heart failure, Curr. Therap. Res., 34:543–557.Google Scholar
  3. 3.
    Azuma, J., Takihara, K., Awata, N., Ohata, H., Sawamura, A., Harada, H., and Kishimoto, S., 1984, Benefician effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits, Res. Commun. Chem. Pathol. Pharmacol., 45:261–270.PubMedGoogle Scholar
  4. 4.
    Bunger, R., Swindall, B., Brodie, D., Zdunek, D., Stiegler, H., and Walter, G., 1986, Pyruvate attenuation of hypoxia damage in isolated working guinea pig heart, J. Mol. Cell. Cardiol., 18:423–438.PubMedCrossRefGoogle Scholar
  5. 5.
    Chovan, J.P., Kulakowski, E.C., Sheakowski, S., and Schaffer, S.W., 1980, Calcium regulation by the low-affinity taurine binding sites of cardiac sarcolemma, Mol. Pharmacol., 17:295–300.PubMedGoogle Scholar
  6. 6.
    Dolara, P., Agresti, A., Giotti, A., and Pasquini, G., 1973, Effect of taurine on calcium kinetics of guinea pig heart, Eur. J. Pharmacol., 24:352–358.PubMedCrossRefGoogle Scholar
  7. 7.
    Franconi, F., Martini, F., Stendardi, I., Matucci, R., Zilletti, L., and Giotti, A., 1982, Effect of taurine on calcium levels and contractility in guinea pig ventricular strips, Biochem. Pharmacol., 31:3181–3185.PubMedCrossRefGoogle Scholar
  8. 8.
    Franconi, F., Stendardi, I., Matucci, R., Bennardini, F., Baccaro, C., and Giotti, A., A protective effect of taurine on hypoxic and reoxygenated guinea pig heart, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro, and M.K. Paasonen, eds., Alan R. Liss, Inc., New York (1985), pp. 177–182.Google Scholar
  9. 9.
    Gaull, G.E., 1986, Taurine as a conditionally essential nutrient in man, J. Am. Coll. Nutr., 5:121–125.PubMedGoogle Scholar
  10. 10.
    Grosso, D.S., and Bressler, R., 1976, Taurine and cardiac physiology, Biochem. Pharmacol., 25:2227–2232.PubMedCrossRefGoogle Scholar
  11. 11.
    Hayes, K.C., Stephen, Z.F., and Sturman, J.A., 1980, growth depression in taurine-depleted infant monkeys, J. Nutr., 110:2058–2064.PubMedGoogle Scholar
  12. 12.
    Huxtable, R.J., Regulation of taurine in the heart, in: “Taurine and Neurological Disorders”, A. Barbeau and R.J. Huxtable, eds., Raven Press, New York (1985), pp. 5–17.Google Scholar
  13. 13.
    Huxtable, R.J., Laird, H.E.II, and Lippincott, S.E., 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharmacol. Exp. Therap., 211:465–471.Google Scholar
  14. 14.
    Huxtable, R.J., and Sebring, L.A., Cardiovascular actions of taurine, in: “Sulfur Amino Acids: Biochemical and Clinical Aspects”, K. Kuriyama, R.J. Huxtable and H. Iwata, Eds., Alan R. Lisa, Inc., New York (1983), pp. 5–37.Google Scholar
  15. 15.
    Iwata, H., and Fujimoto, S., Potentiation by taurine of the inotropic effect of ouabain and the content of intracellular Ca2+ and taurine in the heart, Experientia, 32:1559–1561.Google Scholar
  16. 16.
    Kramer, J.H., Chovan, J.P., and Schaffer, S.W., 1981, Effect of taurine on calcium paradox and ischemic heart failure, Am. J. Physiol., 240:H238–H246.PubMedGoogle Scholar
  17. 17.
    Lake, N., 1983, taurine depletion of lactating rats: effects on developing pups, Neurochem. Res., 8:881–887.PubMedCrossRefGoogle Scholar
  18. 18.
    McBroom, M.J., and Welty, J.D., 1977, Effects of taurine on heart calcium in the cardiomyopathic hamster, J. Mol. Cell. Cardiol., 9:853–858.PubMedCrossRefGoogle Scholar
  19. 19.
    Meerson, F.Z., Kagan, V.E., Kozlov, Y.P., Belkina, L.M., and Arkhipenko, Y.V., 1982, The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart, Basic Res. Cardiol., 77:465–485.PubMedCrossRefGoogle Scholar
  20. 20.
    Mozaffari, M.S., Tan, B.H., Lucia, M.A., and Schaffer, S.W., 1986, Effect of drug-induced taurine depletion on cardiac contractility and metabolism, Biochem. Pharmacol. 35:985–989.PubMedCrossRefGoogle Scholar
  21. 21.
    Nayler, W.G., Poole-Wilson, P.A., and Williams, A., 1979, Hypoxia and calcium, J. Mol. Cell. Cardiol., 11:683–706.PubMedCrossRefGoogle Scholar
  22. 22.
    Neely, J.R., and Grotyohann, L.W., 1984, Role of glycolytic products in damage to ischemic myocardium, Circ. Res., 55:816–824.PubMedCrossRefGoogle Scholar
  23. 23.
    Pasantes-Morales, H., Quesada, O., Carabez, A., and Huxtable, R.J., 1983, Effects of the taurine transport antagonist, guanidinoethane sulfonate, and β-alanine on the morphology of rat retina, J. Neurosci. Res., 9:135–143.PubMedCrossRefGoogle Scholar
  24. 24.
    Pasantes-Morales, H., Wright, C.E., and Gaull, G.E., 1985, Taurine protests lymphoblastoid cells from iron-ascorbate Induced damage, Biochem. Pharmacol., 34:2205–2207.PubMedCrossRefGoogle Scholar
  25. 25.
    Read, W.O., and Welty, J.D., 1963, Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart, J. Pharmacol. Exp. Therap., 139:283–289.Google Scholar
  26. 26.
    Rovetto, M.J., Lamberton, W.F., and Neely, J.R., 1975, Mechanisms of glycolytic inhibition in ischemic rat hearts, Circ. Res., 37:742–751.PubMedCrossRefGoogle Scholar
  27. 27.
    Sawamura, A., Sperelakis, N., and Azuma, J., 1986, Protective effect of taurine against decline of cardiac slow action potentials during hypoxia, Eur. J., Pharmacol., 120:235–239.CrossRefGoogle Scholar
  28. 28.
    Schaffer, S.W., Kramer, J., and Chovan, J.P., 1980, Regulation of calcium homeostasis in the heart by taurine, Fed. Proc., 39:2691–2694.PubMedGoogle Scholar
  29. 29.
    Schaffer, S.W., Kulakowski, E.C., and Kramer, J.H., Taurine transport by reconstituted membrane vesicles, in: “Taurine in Nutrition and Neurology”, R.J. Huxtable and H. Pasantes-Morales, eds., Plenum Press, New York (1982), pp. 143–160.CrossRefGoogle Scholar
  30. 30.
    Schmidt, S.Y., Taurine in retinas of taurine-deficient cats and RCS rats, in: “The Effects of Taurine on Excitable Tissues”, S.W. Schaffer, S.I. Baskin and J.J. Kocsis, Ed., Spectrum Publications, New York (1981), pp. 177–185.CrossRefGoogle Scholar
  31. 31.
    Sebring, L.A., and Huxtable, R.J., 1985, Binding of taurine to cardiac sarcolemma and phospholiposomes, Fed. Proc, 44:2052.Google Scholar
  32. 32.
    Shaffer, J.E., and Kocsis, J.J., Methods of reducing tissue taurine levels, in: “The Effects of Taurine on Excitable Tissues”, S.W. Schaffer, S.I. Baskin and J.J. Kocsis, Eds., Spectrum Publications, Inc., New York (1981), pp. 219–229.CrossRefGoogle Scholar
  33. 33.
    Sturman, J.A., Moretz, R.C., French, J.H., and Wisniewski, H.M., 1985, Postnatal taurine deficiency in the kitten results in a persistence of the cerebellular external granule cell layer: Correction by taurine feeding, J. Neurosci. Res., 13:521–528.PubMedCrossRefGoogle Scholar
  34. 34.
    Vary, T.C., Angelaskos, E.T., and Schaffer, S.W., 1979, Relationship between adenine nucleotide metabolism and irreversible ischemic tissue damage in isolated perfused rat heart, Circ. Res., 45:218–225.PubMedCrossRefGoogle Scholar
  35. 35.
    Welty, M.C., Welty, J.D., and McBroom, M.J., 1982, Effect of isoproterenol and taurine on heart calcium in normal and cardiomyopathic hamsters, J. Mol. Cell. Cardiol., 14:353–357.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • S. W. Schaffer
    • 1
  • S. Allo
    • 1
  • M. Mozaffari
    • 1
  1. 1.Department of PharmacologyUniversity of South Alabama, School of MedicineMobileUSA

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