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Taurine Availability and Function in Neurogenetic Retinopathies

  • Charles E. Wright
  • Harris H. Tallan
  • Tena R. Wright
  • Bruce Gillam
  • Gerald E. Gaull
  • John A. Sturman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

Several neurogenetic diseases manifest abnormal retinal electrophysiology and pathology; such changes in both retinal integrity and function resemble those found in the retina of individuals with retinitis pigmentosa. Some of these inherited neurodegenerative disease include: ceroid lipofuscinosis, Bardet-Beidl-Lawrence-Moon syndrome and Refsum disease, (36). The etiologies of the retinal degeneration observed in these neurogenetic diseases and retinitis pigmentosa remain unknown. Preliminary results, however, from this laboratory (68) and published reports from other investigators (16,21) suggest altered transport of the amino acid taurine in several neurodegenerative diseases.

Keywords

Retinal Pigment Epithelium Free Amino Acid Phytanic Acid Retinal Pigment Epithelial Cell Retinitis Pigmentosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Charles E. Wright
    • 1
  • Harris H. Tallan
    • 1
  • Tena R. Wright
    • 1
  • Bruce Gillam
    • 1
  • Gerald E. Gaull
    • 1
  • John A. Sturman
    • 1
  1. 1.New York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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