Cardiovascular Pharmacology and Experimental Therapeutics of Taurine and Related Compounds

  • Alberto Giotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)


Let me thank the members of the Scientific Committee, Drs. Flavia Franconi, Ryan J. Huxtable, Simo S. Oja and Kenji Yamaguchi for having selected me to lecture in this opening ceremony. The main subject of this lecture is taurine, 2-aminoethane sulfonic acid, an amino acid with zwitterion characteristics, probably a very old molecule widely represented in the animal kingdom, important for osmoregulation in primitive sea animals and also for feeding behavior, in so far as it is a agonist for antennular receptors in the lobster (27), as we shall have the opportunity to discuss in the Symposium (33).


Positive Inotropic Effect Hypo Taurine Taurine Content Taurine Uptake Taurine Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Azuma, J., Sawamura, A., Awata, N., Hasegawa, H., Ogura, K., Harada, H., Ohta, H., Yamaguchi, K., and Kishimoto, S., 1983, Double-blind randomized crossover trial of taurine in congestive heart failure, Current Ther. Res. 34:543–557.Google Scholar
  2. 2.
    Azuma, J., Takihara, K., Awata, N., Ohta, H., Sawamura, A., Harada, H., and Kishimoto, S., 1984, Beneficial effect of taurine on congestive heart failure induced by chronic aortic regurgitation in rabbits, Res. Comm. Chem. Path. Pharm. 45:261–270.Google Scholar
  3. 3.
    Bavazzano, A., Sidell, N., Michelacci, S., Sicuteri, F., 1969, Local ischemia as a kininogen depressant: effect of cortisone, taurine and kallikrein inhibitor, Pharmacol. Res. Comm. 1:137–138.CrossRefGoogle Scholar
  4. 4.
    Becattini, V., 1976, Prospettive di un nuovo farmaco nella terapia delle vasculopatie: la taurina, La Settimana Medica 55:1355–1365.Google Scholar
  5. 5.
    Bennardini, F., Franconi, F., Giotti, A., Matucci, R., and Stendardi, I., 1985, Binding of H-nitrendipine during hypoxia and subsequent reoxygenation, Br. J. Pharmacol. 86:623P.Google Scholar
  6. 6.
    Brodle, B.B., Axelrod, J., Soberman, R., and Levy, B.B., 1949, The estimation of antipyrine in biological materials, J. Biol. Chem. 179:25–29.Google Scholar
  7. 7.
    Buffoni Nardini, F., and Giotti, A., 1955, Titolazione dei glucosidi digitalici nella cavia, II Farmaco, Ed. Pr. 11:615–642.Google Scholar
  8. 8.
    Colucci, W.S., Wright, R.F., and Braunwald, E., 1986, New positive inotropic agents in the treatment of congestive heart failure, First of two parts, N. Engl. J. Med. 314:290–299.PubMedCrossRefGoogle Scholar
  9. 9.
    Colucci, W.S., Wright, R.F., and Braunwald, E., 1986, New positive inotropic agents in the treatment of congestive heart failure, Second of two parts, N. Engl. J. Med. 314:349–358.PubMedCrossRefGoogle Scholar
  10. 10.
    Corr, P.B., and Grafforol, A.W., 1981, Enhanced alpha-adrenergic responsiveness in ischemic myocardium: role of alpha adrenergic blockade, Am. Heart J. 102:605–611.PubMedCrossRefGoogle Scholar
  11. 11.
    Crass, M.F., III and Lombardini, J.B., 1977, Loss of cardiac muscle taurine after acute left ventricular ischemia, Life Sci 21:951–958.PubMedCrossRefGoogle Scholar
  12. 12.
    De Rango, F., and Del Corso, P., 1968, Modificazioni elettrocardiografiche indotte dalla taurina nelle cardiopatie coronariche, Recentl Progressi in Medicina 14:19–51.Google Scholar
  13. 13.
    Dietrich, J., and Diacono, J., 1971, Comparison between ouabain and taurine effects on isolated rat and guinea-pig hearts in low calcium medium, Lif Sci 10:499–507.CrossRefGoogle Scholar
  14. 14.
    Dolara, P., Agresti, A., Giotti, A., and Pasquini, G., 1973, Effect of taurine on calcium kinetics of guinea-pig heart. Eur. J. Pharmacol. 24:352–358.PubMedCrossRefGoogle Scholar
  15. 15.
    Fanciullacci, M., Sicuteri, F., Giotti, A., and Brunetti, S., 1970, La taurina come fibrinolotico nell’uomo: prime osservazioni terapeutiche, La Clinica Terapeutica 53:3–8.PubMedGoogle Scholar
  16. 16.
    Fellman, J.H., Roth, E.S., Avedovech, N.A., and McCarthy, K.D., 1980, The metabolism of taurine to isethionate, Arch. Biochem. Biophys. 204:560–567.PubMedCrossRefGoogle Scholar
  17. 17.
    Franconi, F., Bennardini, F., Matucci, R., Stendardi, I., Failli, P., Manzini, S., and Giotti, A., 1986, Functional and binding evidence of taurine inhibition of alpha adrenoceptor effects on guinea-pig ventricle, J. Mol. Cell Cardiol 18:461–468.PubMedCrossRefGoogle Scholar
  18. 18.
    Franconi, F., Giotti, A., Manzini, S., Martini, F., Stendardi, I., and Zilletti, L., 1982, The effect of taurine on high potassium and noradrenaline-induced contraction in rabbit ear artery, Br. J. Pharmao. 75:605–612.CrossRefGoogle Scholar
  19. 19.
    Franconi, F., Manzini, S., Stendardi, I., Bennardini, F., Antonini, G., Failli, P., Matucci, R., and Giotti, A., 1982, Differential inhibitory effect of taurine on contractile responses to potassium and noradrenaline in rabbit ear artery, J. Pharm. Pharmacol. 35:46–48.CrossRefGoogle Scholar
  20. 20.
    Franconi, F., Martini, F., Manghi, N., Galli, A., Bennardini, F., and Giotti, A., 1981, Uptake of H-Taurine into myocardial membranes, Biochem. Pharmacol. 30:77–80.PubMedCrossRefGoogle Scholar
  21. 21.
    Franconi, F., Martini, F., Stendardi, I., Matucci, R., Zilletti, L., and Giotti, A., 1982, Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips, Biochem. Pharmacol. 31:3181–3185.PubMedCrossRefGoogle Scholar
  22. 22.
    Franconi, F., Stendardi, I., Failli, P., Fazzini, A., and Giotti, A., Inotropic activity of orthanilic and L-cysteic acid on isolated guinea-pig ventricular strips, In this volume.Google Scholar
  23. 23.
    Franconi, F., Stendardi, T., Failli, P., Matucci, R., Baccaro, C, Montorsi, L., Bandinelli, R., and Giotti, A., 1985, The prospective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart, Biochem. Pharmacol. 34:2611–2615.PubMedCrossRefGoogle Scholar
  24. 24.
    Franconi, F., Stendardi, I., Martini, F., Zilletti, L., and Giotti, A., 1982, Interaction between organic calcium-channel blockers and taurine in vitro and in vivo, J. Pharm. Pharmacol. 34:329–330.PubMedCrossRefGoogle Scholar
  25. 25.
    Franconi, F., Stendardi, T., Matucci, R., Failli, P., Bennardini, F., Antonini, G., and Giotti, A., 1984, Inotropic effect of taurine in guinea pig ventricular strips, Eur. J. Pharmacol. 102:511–514.PubMedCrossRefGoogle Scholar
  26. 26.
    Franconi, F., Failli, P., Stendardi, I., Matucci, R., Bennardini, F., Baccaro, C., and Giotti, A., 1986, Positive inotropic effect of some taurine-related compounds on guinea-pig ventricular strips perfused with low calcium medium, Eur. J. Pharmacol. 124:129–133.PubMedCrossRefGoogle Scholar
  27. 27.
    Fuzussery, Z.M., Carr, W.E.S., and Ache, B.W., 1978, Antennular chemosensitivity in the spiny lobster, Panulinus Argus: studies of taurine sensitive receptors, Biol. Bull. 154:226–240.CrossRefGoogle Scholar
  28. 28.
    Gagliarducci, U., 1971, Possibilita’ terapeutiche di un aminoacido solforato nelle eritrocitosi ipo-ossiche, Clin. Ter. 58:145–150.PubMedGoogle Scholar
  29. 29.
    Gagliarducci, U., 1974, Sul trattamento delle cardiopatie ischemiche acute con taurina, Osservazioni cliniche su trenta casi, Clin. Ter. 68:261–270.PubMedGoogle Scholar
  30. 30.
    Giotti, A., 1959, Rapporti fra tempo diastolico, concentrazione degli elettroliti ed effetti della chinidina nel miocardio atriale di mammifero, Lo Sperimentale 109:129–188.Google Scholar
  31. 31.
    Giotti, A., Ledda, F., Franconi, F., Mantelli, L., and Mugelli, A., 1984, Cardiac alpha adrenergic receptors: do they have a role? In: Frontiers in Cardiology for the eighties, ed. by L. Donato and A. L’Abbate, pp. 127–129. Academic Press Inc. Ltd. (London).Google Scholar
  32. 32.
    Giotti, A., Personal observations, Unpublished.Google Scholar
  33. 33.
    Gleeson, R.A., A taurine receptor model: taurine-sensitive olfactory cells in the lobster, This volume.Google Scholar
  34. 34.
    Goodford, P.J. and Lullmann, H., 1962, The uptake of ethanesulphonate-S ions by muscular tissue, J. Physiol. 161:54–61.PubMedGoogle Scholar
  35. 35.
    Guidotti, A., Buffoni, F., and Giotti, A., 1967, Azione della taurina e di alcuni suoi derivati sulla riduzione del consumo di ossigeno prodotta dal cianuro nel ratto, Boll. Soc. Ital. Biol. 43:1390–1392.Google Scholar
  36. 36.
    Guidotti, A., Buffoni, F., and Giotti, A., 1967, Ricerche sull’ interazione taurina-cianuro nel ratto, Boll. Soc. Ital. Bio. Sper. 43:1392–1395.Google Scholar
  37. 37.
    Guidotti, A., Badiani, G., and Giotti, A., 1971, Potentiation by taurine of inotropic effects of straphanthin-K on guinea-pig isolated auricles, Pharmacol. Res. Comm. 3:29–38.CrossRefGoogle Scholar
  38. 38.
    Guidotti, A., and Giotti, A., 1969. Digitalis inotropic effect on the auricular myocardium of taurine, In: Medicaments et metabolism du myocarde, ed. by D. Lamarche et Royer, Nancy, pp. 487-491.Google Scholar
  39. 39.
    Guidotti, A., and Giotti, A., 1970, Taurina e sistema cardiovascolare, Recenti Prog. Med. 49:61–97.PubMedGoogle Scholar
  40. 40.
    Hochachka, P.W., 1986, Defense strategies against hypoxia and hypothermia, Science 231:234–240.PubMedCrossRefGoogle Scholar
  41. 41.
    Huxtable, R.J., 1979, Does taurine have a function? TIPS 1:V–VII.Google Scholar
  42. 42.
    Huxtable, R.J. and Sebring, L.A., 1983, Cardiovascular actions of taurine. In: Sulfur Amino Acids: Biochemical and Clinical Aspects, Liss, A.R., Inc., New York, pp. 5–37.Google Scholar
  43. 43.
    Huxtable, R.J., Laird II, H.E., and Lippincott, S.E., 1979, The transport of taurine in the heart and the rapid depletion of tissue taurine content by guanidinoethyl sulfonate, J. Pharmacol. Exp. Ther. 211:465–470.PubMedGoogle Scholar
  44. 44.
    Jacobsen, J.G., and Smith, L.H., Jr., 1968, Biochemistry and physiology of taurine and taurine derivatives, Physiol. Rev. 48:424–491.PubMedGoogle Scholar
  45. 45.
    Koechlin, B.A., 1954. Isethionic acid, the major anion in axoplasm of squid giant nerve, Federation Proc. 13:80.Google Scholar
  46. 46.
    Levi, R., and Giotti, A., 1967, Effect of Histamine on sinoatrial node cells of rabbit heart, Experientia 23:1–4.CrossRefGoogle Scholar
  47. 47.
    Masini, E., Failli, P., Baccaro, C, Franconi, F., and Giotti, A., Unpublished results.Google Scholar
  48. 48.
    Matucci, R., Bennardini, F., Sciammarella, M.L., Baccaro, C, Stendardi, I., Franconi, F., and Giotti, A., 1983, H-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart, 1987, Biochem. Pharmacol., 36:1059–1062.CrossRefGoogle Scholar
  49. 49.
    McBroom, M.J., and Welty, J.D., 1977, Effects of taurine on heart calcium in the cardiomyopathic hamster, J. Mol. Cell. Cardiol 9:853–858.PubMedCrossRefGoogle Scholar
  50. 50.
    Montanini, R., Zibetti, A., and Gasco, P., 1971, Osservazioni preliminari sull’impiego della taurina nel trattamento delle vasculopatie cerebrali, Clin. Ter. 59:321–329.PubMedGoogle Scholar
  51. 51.
    Read, W.O., and Welty, J.D., 1965, Taurine as a regulator of cell potassium in the heart. In: Electrolytes and Cardiovascular Diseases, Ed. by E. Bajusz, S. Karger, Press Basel, New York, pp. 70–85.Google Scholar
  52. 52.
    Roe, D.A., 1966, Taurine intolerance in psoriasis, J. Invest. Derm. 46:420–430.PubMedGoogle Scholar
  53. 53.
    Schmidt, C.L.A., Von Adelung, E., and Watson, T., 1981, On the elimination of taurine administered to man, J. Biol. Chem. 33:501–503.Google Scholar
  54. 54.
    Thurston, J.H., Hauhart, R.E., and Naccarato, E.F., 1981, Taurine: possible role in osmotic regulation of mammalian heart, Science 214:1373–1374.PubMedCrossRefGoogle Scholar
  55. 55.
    Sicuteri, F., Fanciullacci, N., Franchi, G., Giotti, A., and Guidotti, A., 1970, Taurine as a therapeutic agent in vascular pain, Clin. Med. 77:21–32.Google Scholar
  56. 56.
    Welty, J.D., and McBroom, M.J., 1985, Effects of verapamil and taurine administration on heart taurine and calcium in bio 14.6 cardiomyopathic hamsters, Res. Comm. Chem. Path. Pharmao. 49:141–144.Google Scholar
  57. 57.
    Welty, J.D., and Read, W.O., 1964, Studies on some cardiac effects of taurine, J. Pharmacol. Exp. Ther. 144:110–115.PubMedGoogle Scholar
  58. 58.
    Zanelli, G., Ferrero, S., and Patrone, P., 1971, La taurina nella terapia delle arteriopatie obliteranti degli arti inferior!, Nota I. Risultati clinici nei diversi stadi evolutivi, Minerva Cardioangiol 19:605–615.PubMedGoogle Scholar
  59. 59.
    Zanelli, G., Quaglia, A., and Zino, P., 1971, La taurina nella terapia delle arteriopatie obliteranti degli arti inferiori, Nota II. Variazioni emossimetriche nei diversi stadi evolutivi, Minerva Cardioangiol. 19:616–619.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Alberto Giotti
    • 1
  1. 1.Department of Preclinical and Clinical Pharmacology “Mario Aiazzi Mancini”University of FlorenceFlorenceItaly

Personalised recommendations