Abstract
Chronic infection with hepatitis B virus (HBV) may lead to the development of chronic hepatitis (both chronic persistent and chronic active), post-necrotic cirrhosis and primary hepatocellular carcinoma (PHC). This statement, which does not sound particularly revolutionary now, is directly contrary to the consensus of experts circa 1960 (1). At that time, it was thought that neither infectious nor serum hepatitis (the terms used then) led to chronic liver disease. Chronic hepatitis and cirrhosis, it was thought, were caused by autoimmune or toxic reactions to unidentified agents.
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References
Chalmers, T. C. and Sebestyen, C. S. (1962). Evidence against infectious hepatitis as a cause of cirrhosis. Trans. Amer. Clin. Climat. Assoc. 74:192.
Neefe, J. R., Gambescia, J. M., Kurtz, C. H., Smith, H. D., Beebe, G. W., Jablon, S., Reinhold, J. G., and Williams, S. C. (1955). Prevalence and nature of hepatic disturbance following acute viral hepatitis with jaundice. Ann. Intern. Med. 43:1.
Nefzger, M. D. and Chalmers, T. C. (1963). The treatment of acute infectious hepatitis. Ten-year follow-up study of the effects of diet and rest. Am. J. Med. 35:299.
Gitnick, G. L., Schoenfield, L. J., Sutnick, A. I., London, W. T., Gleich, G. J., Baggenstoss, A. H., Blumberg, B. S., and Summerskill, W. H. (1969). Australia antigen in chronic active liver disease with cirrhosis. Lancet 2:285.
Wright, R., McCollum, R. W., and Klatskin, G. (1969). Australia antigen in acute and chronic liver disease. Lancet 2:117.
Hann, H. L., Kim, C. Y., London, W. T., Whitford, P., and Blumberg, B. S. (1982). Hepatitis B virus and primary hepatocellular carcinoma: Family studies in Korea. Int. J. Cancer 30:47.
Simon, J. B. and Patel, S. (1974). Liver disease in asymptomatic carriers of hepatitis B antigen. Gastroenterology 66:1028.
Vittal, S. B., Dourdourekas, D., Shobassy, N., Gerber, M., Teleschi, J., Szanto, P., Stegman, F., and Clowdus, B. F. (1974). Asymptomatic hepatic disease in blood donors with hepatitis B antigenemia. Am. J. Clin. Pathol. 62:649.
DeFranchi, R., D’Arraino, A., Vecchi, M., Ronchi, G., del Ninno, F., Pariavacini, A., Ferroni, P., and Zanetti, P. (1980). Chronic asymptomatic HBsAg carriers: Histologic abnormalities and diagnostic and prognostic value of serologic markers of the HBV. Gastroenterology 79:521.
Dragosics, B., Franci, P., Denk, H. and Wewalka, F. (1982). Clinical and histological long-term study of HBsAg(+) voluntary blood donors in Austria. Hepatology 2:747.
London, W. T. (1981). Primary hepatocellular carcinoma. Human Pathol. 12:1085.
Larouze, B., London, W. T., Saimot, G., Werner, B. G., Lustbader, E. D., Payet, M., and Blumberg, B. S. (1976). Host responses to hepatitis B infection in patients with primary hepatic cancer and their families. A case/control study in Senegal, West Africa. Lancet 2:534.
Nayak, N. C., Dhar, A., Sachdeva, R., Mittal, A., Seth, H. N., Sudarsanam, D., Reddy, B., Waghaolikar, U. L., and Reddy, C.R.R.M. (1977). Association of human hepatocellular carcinoma and cirrhosis with hepatitis virus surface and core antigens in the liver. Int. J. Cancer 20:643.
Shafritz, D., Shouval, D., Sherman, H. I., Hadziyannis, S. J., and Kew, M. C. (1981). Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. N. Engl. J. Med. 305:1067.
Brechot, C., Pourcel, C., Hadchouel, M., Dejean, A., Louise, A., Scotto, J., and Tiollais, P. (1982). State of hepatitis B virus DNA in liver diseases. Hepatology 2:275.
Beasley, R. P., Lin, C.-C., Hwang, L.-Y., and Chien, C.-S. (1981). Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet 2:1129.
Beasley, R. P. (1982). Hepatitis B virus as the etiologic agent in hepatocellular carcinoma — Epidemiologic considerations. Hepatology 2:21S.
Sakuma, K., Takara, T., Okuda, K., Tsudo, F., and Mayumi, M. (1982). Prognosis of hepatitis B virus surface antigen carriers in relation to routine liver function tests: A prospective study. Gastroenterology 83:144.
Obata, H., Hayashi, N., Motoike, Y., Hisamits, T., Okuda, H., Kubayashi, S., and Nishioka, K. (1980). A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B infection. Int. J. Cancer 25:741.
Summers, J., Smolec, J. M., and Snyder, R. (1978). A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc. Natl. Acad. Sci. (USA) 75:4533.
Snyder, R. L. and Summers, J. (1980). Woodchuck hepatitis virus and hepatocellular carcinoma, in Viruses in Naturally Occurring Cancers, M. Essex, G. Todaro and H. zur Hausen, eds., pp. 447-457, Cold Spring Harbor Conferences on Cell Proliferation, Cold Spring Harbor Laboratory.
Ogston, C. W., Jonak, G. J., Rogler, C. E., Astrin, S. M., and Summers, J. (1982). Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of wood-chucks. Cell 29:385.
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London, W.T. (1984). Medical Consequences of the Carrier State. In: Millman, I., Eisenstein, T.K., Blumberg, B.S. (eds) Hepatitis B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0369-3_4
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DOI: https://doi.org/10.1007/978-1-4899-0369-3_4
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