Keynote Address: The Australia Antigen Story

  • Baruch S. Blumberg


I would like to welcome visitors to Philadelphia and remind them that we are in the midst of celebrating our 300th birthday and looking forward to our fourth century as a thriving city. For the past year the city has undertaken an orgy of reminiscences and the commemoration of historic events. Philadelphia is gifted in preserving and recalling its past, and we would like to think that we are also interested in the development of an exciting future. All this historical reminiscing may provide an adequate excuse to look back at the work that we have done at the Institute for Cancer Research over the past 18 years which led to the discovery of the hepatitis B virus, the invention of the vaccine to protect against it, the possibility of prevention of primary cancer of the liver, and the many developments in our knowledge of this interesting virus. I hope that our extended discussion of the past won’t detract from an interest in our current work, to which I will also refer briefly.


Primary Liver Cancer Keynote Address Primary Hepatocellular Carcinoma Chronic Carrier Australia Antigen 
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  1. 1.
    Allison, A. C., Blumberg, B. S., and Rees, A. P. (1958). Haptoglobin types in British, Spanish Basque and Nigerian African populations. Nature 181:824–825.PubMedCrossRefGoogle Scholar
  2. 2.
    Blumberg, B. S., Allison, A. C., and Garry, B. (1959). The haptoglobins and hemoglobins of Alaskan Eskimos and Indians. Ann. Hum. Genet. 23:340–356.CrossRefGoogle Scholar
  3. 3.
    Blumberg, B. S., Dray, S., and Robinson, J. C. (1962). Antigen polymorphism of a low-density beta-lipoprotein. Allotype in human serum. Nature 194:656–658.CrossRefGoogle Scholar
  4. 4.
    Blumberg, B. S., Alter, H. J., and Visnich, S. (1965). A “new” antigen in leukemia sera. J. Am. Med. Assoc. 191:541–546.CrossRefGoogle Scholar
  5. 5.
    Blumberg, B. S., Gerstley, B. J. S., Hungerford, D. A., London, W. T., and Sutnick, A. I. (1967). A serum antigen (Australia antigen) in Down’s syndrome leukemia and hepatitis. Ann. Intern. Med. 66:924–931.PubMedCrossRefGoogle Scholar
  6. 6.
    Sutnick, A. I., London, W. T., Gerstley, B. J. S., Cronlund, M. M., and Blumberg, B. S. (1968). Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down’s syndrome. J. Amer. Med. Assoc. 205:670–674.CrossRefGoogle Scholar
  7. 7.
    Bayer, M. E., Blumberg, B. S., and Werner, B. (1968). Particles associated with Australia antigen in the sera of patients with leukemia, Down’s syndrome and hepatitis. Nature 218:1057–1059.PubMedCrossRefGoogle Scholar
  8. 8.
    Dane, D. S., Cameron, C. H., and Briggs, M. (1970). Viruslike particles in serum of patients with Australia antigen-associated hepatitis. Lancet 1:695–698.PubMedCrossRefGoogle Scholar
  9. 9.
    Okochi, K. and Murakami, S. (1968). Observations on Australia antigen in Japanese. Vox. Sang. 15:374–385.PubMedCrossRefGoogle Scholar
  10. 10.
    Blumberg, B. S. and Millman, I. Vaccine against viral hepatitis and process. Serial No. 864,788 filed 10/8/69, Patent 36 36 191 issued 1/18/72, U.S. Patent Office.Google Scholar
  11. 11.
    Okochi, K., Murakami, S., Ninomiya, K., and Kaneko, M. (1970). Australia antigen, transfusion and hepatitis. Vox. Sang. 18:289–300.CrossRefGoogle Scholar
  12. 12.
    Senior, J. R., Sutnick, A. I., Goeser, E., London, W. T., Dahlke, M. D., and Blumberg, B. S. (1974). Reduction of post-transfusion hepatitis by exclusion of Australia antigen from donor blood in an urban public hospital. Am. J. Med. Sci. 261:171–177.CrossRefGoogle Scholar
  13. 13.
    Blumberg, B. S., London, W. T., and Sutnick, A. I. (1969). Relation of Australia antigen to virus of hepatitis. Bull. of Path. 10:164.Google Scholar
  14. 14.
    Goche, D. J. and Kavey, N. B. (1969). Hepatitis antigen: correlation of disease with infectivity of blood donors. Lancet 1:1055.CrossRefGoogle Scholar
  15. 15.
    Alter, H. J., Holland, P. V., and Schmidt, P. J. (1970). Hepatitis-associated antigen: to test or not to test? Lancet 2:142–143.PubMedCrossRefGoogle Scholar
  16. 16.
    Ad hoc committee on hepatitis-associated antigen. (1971). Statement concerning the use of hepatitis-associated antigen tests for donor screening in blood banks. Transfusion 11:1–3.CrossRefGoogle Scholar
  17. 17.
    Blumberg, B. S., Melartin, L., Guinto, R. A., and Werner, B. (1966). Family studies of a human serum isoantigen system (Australia antigen). Am. J. Hum. Genet. 18:594–608.PubMedGoogle Scholar
  18. 18.
    Blumberg, B. S., Friedlaender, J. S., Woodside, A., Sutnick, A. I., and London, W. T. (1969). Hepatitis and Australia antigen. Autosomal recessive inheritance of susceptibility to infection in humans. Proc. Natl. Acad. Sci. (USA) 62:1108–1115.CrossRefGoogle Scholar
  19. 19.
    Blumberg, B. S., Sutnick, A. I., London, W. T., and Melartin, L. (1972). Sex distribution of Australia antigen. Arch. Intern. Med. 130:227–231.PubMedCrossRefGoogle Scholar
  20. 20.
    London, W. T. and Drew, J. S. (1977). Sex differences in response to hepatitis B infection among patients receiving chronic dialysis treatment. Proc. Natl. Acad. Sci. (USA) 74:2561–2563.CrossRefGoogle Scholar
  21. 21.
    Kukowski, K., London, W. T., Sutnick, A. I., Kahn, M., and Blumberg, B. S. (1972). Comparison of progeny of mothers with and without Australia antigen. Human Biol. 44:489–500.PubMedGoogle Scholar
  22. 22.
    Hesser, J. E., Economidou, J., and Blumberg, B. S. (1975). Hepatitis B surface antigen (Australia antigen) in parents and sex ratio of offspring in a Greek population. Human Biol. 47:415–425.PubMedGoogle Scholar
  23. 23.
    Drew, J. S., London, W. T., Lustbader, E. D., Hesser, J. E., and Blumberg, B. S. (1978). Hepatitis B virus and sex ratio of offspring. Science 201:687–692.PubMedCrossRefGoogle Scholar
  24. 24.
    Drew, J., London, W. T., Blumberg, B. S., and Serjeantson, S. (1982). Hepatitis B virus and sex ratio on Kar Kar Island. Human Biol. 54:123–135.PubMedGoogle Scholar
  25. 25.
    London, W. T., Stevens, R. G., Shofer, F. S., Drew, J. S., Brunhofer, J. E., and Blumberg, B. S. (1982). Effects of hepatitis B virus on the mortality, fertility, and sex ratio of human populations, in Viral Hepatitis, 1981 International Symposium, W. Szmuness, H. J. Alter and J. E. Maynard, eds., Franklin Institute Press, Philadelphia, pp. 195–202.Google Scholar
  26. 26.
    London, W. T., Drew, J. S., Blumberg, B. S., Grossman, R. A., and Lyons, P. J. (1977). Association of graft survival with host response to hepatitis B infection in patients with kidney transplants. N. Engl. J. Med. 296:241–244.PubMedCrossRefGoogle Scholar
  27. 27.
    Prince, A. M., Metselaar, D., Kafuko, G. W., Mukwaya, L. G., Ling, C. M., and Overby, L. R. (1972). Hepatitis B antigen in wild-caught mosquitoes in Africa. Lancet 2:247–250.PubMedCrossRefGoogle Scholar
  28. 28.
    Blumberg, B. S., Wills, W., Millman, I., and London, W. T. (1973). Australia antigen in mosquitoes. Feeding experiments and field studies. Res. Commun. Chem. Path. Pharm. 6:719–732.PubMedGoogle Scholar
  29. 29.
    Wills, W., Saimot, G., Brochard, C., Blumberg, B. S., London, W. T., Dechene, R., and Millman, I. (1976). Hepatitis B surface antigen (Australia antigen) in mosquitoes collected in Senegal, West Africa. Am. J. Trop. Med. Hyg. 25:186–190.PubMedGoogle Scholar
  30. 30.
    Ogston, C. W., Wittenstein, F. S., London, W. T., and Millman, I. (1979). Persistence of hepatitis B surface antigen in the bedbug Cimex hemipterus (Fabr.). J. Infect. Dis. 140:411–414.PubMedCrossRefGoogle Scholar
  31. 31.
    Ogston, C. W., and London, W. T. (1980). Excretion of hepatitis B surface antigen by the bedbug Cimex hemipterus Fabr. Trans. Roy. Soc. Trop. Med. Hyg. 74:823–825.PubMedCrossRefGoogle Scholar
  32. 32.
    London, W. T. and Blumberg, B. S. (1982). Hepatitis B and related viruses in chronic hepatitis, cirrhosis and hepatocellular carcinoma in man and animals, in Chronic Active Liver Disease, S. Cohen and R. D. Soloway, eds., Churchill Livingstone, New York, pp. 147–170.Google Scholar
  33. 33.
    Blumberg, B. S., and London, W. T. (1983). Hepatitis B virus pathogenesis and prevention of primary cancer of the liver, in Accomplishments in Cancer Research 1981, General Motors Cancer Research Foundation, J. G. Fortner and J. E. Rhoads, eds., J. B. Lippincott Company, Philadelphia, pp. 184–201.Google Scholar
  34. 34.
    London, W. T. (1981). Primary hepatocellular carcinoma—etiology, pathogenesis, and prevention. Human Pathology 12:1085–1097.PubMedCrossRefGoogle Scholar
  35. 35.
    Blumberg, B. S., Larouze, B., London, W. T., Werner, B., Hesser, J. E., Millman, I., Saimot, G., and Payet, M. (1975). The relation of infection with the hepatitis B agent to primary hepatic carcinoma. Am. J. Pathol. 81:669–682.PubMedGoogle Scholar
  36. 36.
    Nayak, N. C., Dhark, A., Sachdeva, R., Mittal, A., Seth, H. N., Sudarsanam, D., Reddy, B., Wagholikar, U. L., and Reddy, C. R. R. M. (1977). Association of human hepatocellular carcinoma and cirrhosis with hepatitis B virus surface and core antigens in the liver. Int. J. Cancer 20:643.PubMedCrossRefGoogle Scholar
  37. 37.
    Omata, M., Ashcavi, M., Liew, C-T., and Peters, R. L. (1979). Hepatocellular carcinoma in the U.S.A., etiologic considerations: localization of hepatitis B antigens. Gastroenterology 76:279.PubMedGoogle Scholar
  38. 38.
    Beasley, R. P., Lin, C-C., Hwang, L-Y., and Chien, C-S. (1981). Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22,707 men in Taiwan, Lancet 2:1129.PubMedCrossRefGoogle Scholar
  39. 39.
    Obata, H., Hayashi, N., Motoike, Y., et al. (1980). A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection. Int. J. Cancer 25:741.PubMedCrossRefGoogle Scholar
  40. 40.
    Larouze, B., London, W. T., Saimot, G., Werner, B. G., Lustbader, E. D., Payet, M., and Blumberg, B. S. (1976). Host responses to hepatitis B infection in patients with primary hepatic carcinoma and their families. A case/control study in Senegal, West Africa. Lancet 2:534–538.Google Scholar
  41. 41.
    Hann, H. L., Kim, C. Y., London, W. T., Whitford, P., and Blumberg, B. S. (1982). Hepatitis B virus and primary hepatocellular carcinoma: Family studies in Korea. Int. J. Cancer 30:47–51.PubMedCrossRefGoogle Scholar
  42. 42.
    Summers, J., O’Connell, A., Maupas, P., Goudeau, A., Coursaget, P., and Drucker, J. (1978). Hepatitis B virus DNA in primary hepatocellular carcinoma tissue. J. Med. Virol. 2:207–214.PubMedCrossRefGoogle Scholar
  43. 43.
    London, W. T. Observations on hepatoma, in Viral Hepatitis, G. N. Vyas, S. N. Cohen and R. Schmid, eds., Franklin Institute Press, Philadelphia, pp.455-458.Google Scholar
  44. 44.
    Macnab, G. M., Alexander, J. J., Lecatsas, G., Bey, E. M.,. and Urbanowicz, J. M. Hepatitis B surface antigen produced by a human hepatoma cell line. Br. J. Cancer 34:509.Google Scholar
  45. 45.
    Skelly, J., Copeland, J. A., Howard, C. R., and Zuckerman, A. J. (1979). Hepatitis B surface antigen produced by a human hepatoma cell line. Nature 282:617.PubMedCrossRefGoogle Scholar
  46. 46.
    Marion, P. L. and Robinson, W. S. (1980). Hepatitis B virus and hepatocellular carcinoma, in Viruses in Naturally Occurring Cancers, M. Essex, G. Todaro and H. zur Hausen, eds., Cold Spring Harbor Conferences on Cell Proliferation, Vol. 7, Cold Spring Harbor: Cold Spring Harbor Laboratory, pp. 423.Google Scholar
  47. 47.
    Gray, P., Edman, J. C., Valenzuela, P., Goodman, H. M., and Rutter, W. J. (1980). A human hepatoma cell line contains hepatitis B DNA and RNA sequences. J. Supramolec. Struc. (Suppl). 4:245.Google Scholar
  48. 48.
    Brechot, C., Pourcel, C., Louise, A., Rain, B., and Tiollais, P. (1980). Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 286:533.PubMedCrossRefGoogle Scholar
  49. 49.
    Knowles, B. B., Howe, C. C., and Aden, D. P. (1980). Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497.PubMedCrossRefGoogle Scholar
  50. 50.
    Shafritz, D. A., Shouval, D., Sherman, H. I., Hadziyannis, S. J., and Kew, M. C. (1981). Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. N. Engl. J. Med. 305:1067.PubMedCrossRefGoogle Scholar
  51. 51.
    Blumberg, B. S., Millman, I., Sutnick, A. I., and London, W. T. (1971). The nature of Australia antigen and its relation to antigen-antibody complex formation. J. Exp. Med. 134:320–329.PubMedGoogle Scholar
  52. 52.
    Summers, J., Smolec, J. M., and Snyder, R. (1978). A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc. Natl. Acad. Sci. USA 75:4533.PubMedCrossRefGoogle Scholar
  53. 53.
    Werner, B. G., Smolec, J. M., Snyder, R., and Summers, J. (1979). Serological relationship of woodchuck hepatitis virus to human hepatitis B virus. J. Virol. 32:314–322.PubMedGoogle Scholar
  54. 54.
    Blumberg, B. S. (1981). Viruses similar to hepatitis B virus (Icrons). Human Pathology 12:1107–1113.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Baruch S. Blumberg
    • 1
  1. 1.Institute for Cancer ResearchFox Chase Cancer CenterPhiladelphiaUSA

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