Hepatitis B pp 161-174 | Cite as

Hepatitis B Vaccine Trials, Experience and Review

  • Robert E. Weibel


Demonstrating the relationship between Australia antigen and hepatitis B virus in the late 1960’s created a serologic means for detecting hepatitis B infection, disease, carriers, and recovery (1,2). This information provided an impetus for vaccine development even in the absence of a means to propagate the virus in the laboratory. Individuals chronically infected with hepatitis B could be identified and their infected plasma containing infectious hepatitis B virus (HBV) or Dane particles and excess hepatitis B surface antigen (HBsAg) obtained by plasmaphoresis (3). Additional markers (shown in Figure 1) of human hepatitis B infection and recovery were further identified as important serologic markers. These include hepatitis B surface antigen (HBsAg) and its antibody (anti-HBs), hepatitis B core antigen and its antibody (anti-HBc), and the hepatitis Beantigen and its antibody (anti-HBe). By use of these and other tests, it is possible to identify susceptibles from immunes and the probable state of infection of the carriers. Persons who have never had hepatitis B are free of all markers.


Protective Efficacy Vaccine Trial Untoward Effect Seroconversion Rate Core Antigen 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Robert E. Weibel
    • 1
  1. 1.The Joseph Stokes, Jr. Research InstituteThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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