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Uremia Therapy

Innovations Promise Near-Term Improvement
  • Eli A. Friedman

Abstract

Few universally fatal diseases have benefited from therapy to the extent that irreversible uremia has responded to maintenance hemodialysis and renal transplantation. Before 1960, when Scribner and co-workers devised a regimen for repetitive hemodialysis1 every chronic uremic patient with the exception of monozygotic twin kidney recipients had no hope of living more than a few weeks once residual renal function fell below a creatinine clearance of 2 ml/min. In 1980, a choice of three effective therapies, each capable of prolonging useful life for years, are available to preempt death in renal failure (Figure 1).

Keywords

Peritoneal Dialysis Continuous Ambulatory Peritoneal Dialysis Uremic Patient Maintenance Hemodialysis Residual Renal Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hegstrom, R. M., Murray, J. S., Pendras, J. P., et al. Hemodialysis in the treatment of chronic uremia. Transactions of the American Society of Artificial Internal Organs, 1961, 7, 136–149.Google Scholar
  2. 2.
    Friedman, E. A., Delano, B. G., and Butt, K. M. H. Pragmatic realities in uremia therapy. New England Journal of Medicine, 1978, 298, 368–371.PubMedCrossRefGoogle Scholar
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    Popovich, R. P., Moncrief, J. W., Decherd, J. B., et al. The definition of a novel portable/wearable equilibrium peritoneal dialysis technique. American Society of Artificial Internal Organs, 1976, 5, 64.Google Scholar
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    Oreopoulos, D. G. The coming of age of continuous ambulatory peritoneal dialysis (CAPD), Dialysis and Transplantation, 1979, 8, 460–461.Google Scholar
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    Manis, T., and Friedman, E. A. Dialytic therapy for irreversible uremia (First of two parts). New England Journal of Medicine, 1979, 301, 1260–1265.PubMedCrossRefGoogle Scholar
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    Manis, T., and Friedman, E. A. Dialytic therapy for irreversible uremia (Second of two parts) New England Journal of Medicine, 1979, 301, 1321–1328.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Eli A. Friedman
    • 1
  1. 1.Downstate Medical CenterState University of New YorkBrooklynUSA

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