Pituitary Desensitization with a Long-Acting Luteinizing-Hormone-Releasing Hormone Analog
Normal puberty appears to be initiated by the pulsatile secretion of luteinizing-hormone-releasing hormone (LHRH) from the hypothalamus at a frequency of about 1 pulse/hr (see Figure 1) (Boyar, Finkelstein, Roffwarg, Kapen, Weitzman, and Hellman, 1972; Knobil, 1980). The pulsatile secretion of LHRH stimulates secretion of the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate gonadal sex steroid secretion. The rise in the gonadal sex steroids estradiol and testosterone induces the secondary sexual changes at puberty.
KeywordsLuteinizing Hormone Precocious Puberty Medroxyprogesterone Acetate LHRH Agonist Gonadal Dysgenesis
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