Abstract
The complications involved in the assessment of the risk to humans following exposure to polychlorinated dibenzodioxins (PCDDs) are numerous. The principal difficulty is the absence of any hard data on the actual concentration of PCDDs to which individuals were exposed. In some cases exposure to the dioxins may have been an isolated event, but in the majority of instances contact with the chemical probably occurred over a prolonged period. In addition to which individuals would probably have been exposed to a number of other chemicals at the same time. Introducing other factors into the risk equation has the effect of “confounding” the overall picture—making interpretation of any result far more involved.
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References
Hay, A. W. M. Tetrachloradibenzo-p-dioxin release at Seveso, Disasters 1, 284–308 (1977).
Young, A. L., Calcagni, J. A., Thalken, C. E., and Tremplay, J. W. The toxicology, environmental fate, and human risk of herbicide orange and its associated dioxin, Report OEHL TR-78-92, USAF Occupational and Environmental Health Laboratory, Aerospace Medical Division (AFSC), Brooks Air Force Base, Texas 78735 (1978).
Holmstedt, B. Prolegomena to Seveso, Archives of Toxicology 44, 211–230 (1980).
Ashe, W. F., and Suskind, R. R. Report—Patients from Monsanto Chemical Company, Nitro, West Virginia, Internal Monsanto report (5 December 1949).
Ashe, W. F., and Suskind, R. R. Progress Report—Patients from Monsanto Chemical Company, Nitro West Virginia (April 1950).
Suskind, R. R. A review of occupational exposures to dibenzo-p-dioxins, presentation to a conference on dibenzodioxins/dibenzofurans, Rougemont, North Carolina (18 November 1976).
Zack, J. A., and Suskind, R. R. The mortality experience of workers exposed to tetrachloradibenzo-dioxin in a trichlorophenol process accident, Journal of Occupational Medicine 22, 11–14(1980).
Baader, E. W., and Bauer, H. J. Industrial intoxication due to pentachlorophenol, Industrial Medicine and Surgery 20, 286–290 (1951).
Bauer, H., Schultz, K. H., and Spielgalberg, U. Occupational intoxication in the manufacture of chlorophenol compounds, Archiv fuer Gewerbepathologie und Gewarbehygiene 18, 538–555 (1961).
Hay, A. W. M. Exposure to TCDD: The health risks, in Chlorinated Dioxins and Related Compounds by O. Hutzinger (ed.) Pergamon Press, Oxford and New York (1982), pp. 589–600.
Goldmann, P. J. Schwerste akute Chlorakne durch Trichlorphenol—Zersetzungsprodukte, Arbeitsmedizin Sozialmedizin Arbeitshygiene 7, 12–18 (1972).
Goldmann, P. J. Schwerste akute Chlorakne, eine Massenintoxikation durch 2,3,6,7-Tetrachlor-dibenzodioxin, Hautarzt 24, 149–152 (1973).
Thiess, A. M., and Frentzel-Beyme, R. Mortality study of persons exposed to dioxin after an accident which occurred in the BASF on 13.11.1953, Vth International Medichem Congress, San Francisco (5 September 1977) (follow-up study of workers exposed in 1953).
IARC: Joint NIEHS/IARC Working Group Report, Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans, International Agency for Research on Cancer, Lyon, France (1978).
Dugois, P., Marechal, J., and Colomb, L. Chloracne caused by 2,4,5-trichlorophenol, Archives des Maladies Professionnelles Hygiene et Toxicologie Industrielles 19, 626–627 (1958).
Kimmig, J., and Schulz, K. H. Occupational acne (so-called chloracne) due to chlorinated aromatic cyclic ethers, Dermatologica 115, 540–546 (1957).
Kimmig, J., and Schulz, K. H. Chlorierte aromatische Zyklische Ather als Ursache der sogenannten Chlorakne, Naturwissenschaften 44, 337-338 (1957) (the important summary by Schulz of the properties of dioxin (TCDD)).
Kraus, Von L., and Brassow, H. Katamnestischer Beitrag zu sog. Chlorakneerkrankungen aus dem Jahre 1954/55, Arbeitsmedizin Socialmedizin Praeventivmedizin 13, 19–21 (1978).
Bleiburg, J., Wallen, M., Brodkin, R., and Appelbaum, I. L. Industrially acquired porphyria, Arch. Dermatol 89, 793–797 (1964).
Poland, A. P., Smith, D., Metter, G., and Possick, P. A health survey of workers in a 2,4-D and 2,4,5-T plant, Archives of Environmental Health 22, 316–327 (1971).
Hofman, M. F., and Meneghini, C. L. A proposito delle follicolosi da idrocarburi clorosostituito (acne chlorica), Giornale Italiano di Dermatologia 103, 427–450 (1962).
Dalderup, L. M. Safety measures for taking down buildings contaminated with toxic material, I. T. Soc. Geneesk. 52, 582–588 (1974).
Dalderup, L. M. Safety measures for taking down buildings contaminated with toxic material, II. T. Soc. Geneesk. 52, 616–623 (1974).
Vos, J. G., Workshop on Dibenzodioxins and dibenzofurans, paper presented at the International Agency for Research on Cancer (reported in Reference 14).
Telegina, K. A., and Bikbulatova, L. I. Afflication of the follicular apparatus of the skin in workers occupied in the production of butyl ether of 2,4,5-trichlorophenoxyacetic acid, Vestnik Dermatologii i Venerologii 44, 35–39 (1970).
Firestone, D. The 2,3,7,8-tetrachlorodibenzo-para-dioxin problem. A review, in Chlorinated phenoxy acids and their dioxins: Mode of action, Health risks and environmental effects, Ecol Bull. (Stockh.) 27 39–52 (1978).
Jirasek, L., Kalensky, J., and Kubec, K. Acne chlorina and porphyria cutanea tarda during the manufacture of herbicides, Ceskoslovenska Dermatologie 48, 306–317 (1973).
Jirasek, L., Kalensy, J., Kubeck, K., Pazderova, J., and Lukas, E. Acne chlorina porphyria cutanea tarda and other manifestations of general intoxication during the manufacture of herbicides. II Ceskoslovenska Dermatologie 49, 145–157 (1974).
Jirasek, L., Kalensky, J., Kubeck, K., Pazderova, J., and Lukas, E. Chlorakne, porphyria cutanea tarda und andere intoxikationen durch herbizid., Hautarzt 27, 328–323 (1976).
May, G. Chloracne from the accidental production of tetrachloradibenzodioxin. Properties of TCDD, British Journal of Industrial Medicine 30, 276–283 (1973).
Oliver, R. M. Toxic effects of 2,3,7,8-tetrachlorodibenzo-l,4-dioxin in laboratory workers, British Journal of Industrial Medicine 32, 49–53 (1975).
Mivra, H., Omori, A., Shibue, M. The effect of chlorophenols on the excretion of porphyrins in urine, Japanese Journal of Industrial Health 16, 575–577 (1974).
Zelikov, A. K., and Danilov, L. N. Occupational dermatoses (acnes) in workers engaged in production of 2,4,5-trichlorophenol, Sovetskaya Meditsina 7, 145–146 (1974).
Hay, A. Toxic cloud over Seveso, Nature (London) 262, 636–638 (1976).
Hay, A. Seveso: the aftermath, Nature (London) 263, 538–540 (1976).
Reggiani, G. Toxic effects of TCDD in man, presented to a NATO Workshop on Ecotoxicology, Guildford, England (August 1977).
Minutes of Chloracne meeting on 7 November 1979, Health and Safety Executive.
Theiss, A. M., and Frentzel-Beyme, R. Mortality study of persons exposed to dioxin after an accident which occurred in the BASF on 13 November 1953, 5th International Medichem Congress, San Francisco (5–9 September 1977).
Monsanto
Zack, J. A., and Suskind, R. R. The mortality experience of workers exposed to tetrachlorodibenzodioxin in a trichlorophenol process accident, Journal of Occupational Medicine 22, 11–14 (1980).
Suskind, R. R. Personal letter, 29 February 1980.
Ashe, W. F., and Suskind, R. R. Report—Patients from Monsanto Chemical Company, Nitro, West Virginia (5 December 1949).
Oliver, R. M. Toxic effects of 2,3,7,8-tetrachlorodibenzo-l,4-dioxin in laboratory workers, British Journal of Industrial Medicine 32, 49–53 (1975).
Walker, A. E., and Martin, J. V. Lipid profiles in dioxin-exposed workers, Lancet I, 446 (1979).
Ashe, W. F., and Suskind, R. R. Progress report—Patients from Monsanto Chemical Company, Nitro, West Virginia (April 1959).
Crow, K. D. Unpublished data (1979).
Honchar, P. A., and Halperin, W. E. 2,4,5-T, trichlorophenol and soft tissue sarcoma, Lancet I, 268–269 (1981).
Cook, R. R. Dioxin, chloracne and soft tissue sarcoma. Lancet I, 618–619 (1981).
Zack, J., and Suskind, R. R. Details given in pr newswire, St. Louis (9 October 1980) (to be published.
BASF
BASF Annual Report (1977).
Borkin, J. The Crime and Punishment of IG Farben, The Free Press, New York and London (1978).
Theiss, A. N., and Frentzel-Beybe, R. Mortality Study of Persons Exposed to Dioxin after an Accident which Occurred in the BASF on 13 November 1953, Vth International Medichem Congress, San Francisco (5–9 September 1977).
Goldmann, Von, P. J. Schwerste skute durch Trichlorophenolzersetzungsprodukte, Arbeitsmedizin Sozialmedizin Arbeitshygiene 7, 12–18 (1972).
Goldmann, P. J. Schweste skute chloracne, eiene Massenintoxikation durch 2,3,6,7-tetrachlorodibenzodioxin, Hautarzt 24, 149–152 (1973).
Hay, A. Dioxin meeting recommends cancer study, Nature (London) 271, 202 (1978).
International Agency for Research and Cancer, Long term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans, IARC Internal Technical Report No. 78/001 (June 1978).
Theiss, A. M., Frentzel-Beyme, R., and Link, R. Mortality study of persons exposed to dioxin in a trichlorophenol-process accident which occurred in the BASF AG on November 17, 1953 (in press).
Rohrborn, G., Goldmann, P., and Fleig, I. Chromosomenanalyse bei Mitarbeitern mit Exposition gegenuber 2,3,7,8-tetrachlorodibenzodioxin (TCDD)—Umfallgeschehen am 17 November 1953 (unpublished).
Huff, J. E. Personal letter, 2 October 1978.
Philips-Duphar
Dalderup, L. M. Safety measures for taking down buildlings contaminated with toxic material I, T. Soc. Geneesk 52, 582-585 (in English).
Dalderup, L. M. Safety measures for taking down buildings contaminated with toxic material II, T Soc. Geneesk 52, 616-623 (in English).
Masterman, S. The Times, 9 August 1976.
Hay, A. Toxic cloud over Seveso, Nature (London) 262, 636–638 (1976).
Vos, J. G., Sterringa, Tj., Zellenrath, D., Docter, H. J., and Dalderup, L. M. TCDD accident at a chemical factory in the Netherlands, presented at a joint National Institute of Environmental Health Sciences/International Agency for Research on Cancer Working Group on the Long Term Hazards of Chlorinated Dibenzodioxins and Dibenzofurans, IARC, Lyon (10–11 January 1978).
Schuuring, C. Toxic waste: Dutch dumps, Nature (London) 289, 340 (1981).
Barnaby, W. Personal communication (April 1981).
Coalite and Chemical Products Limited
Anonymous, The Sheffield Star, 24 April 1968.
Coalite Group, Report and Accounts 1977/1978.
Milnes, M. H. Formation of 2,3,7,8-tetrachlorodibenzodioxin by thermal decomposition of sodium trichlorophenate, Nature (London) 232, 395–396 (1971).
May, G. Chloracne from the accidental production of tetrachlorodibenzodioxin, British Journal of Industrial Medicine 30, 276–283 (1973).
Anonymous, The Sheffield Morning Telegraph, 17 May 1968.
Adams, E. M., Irish, D. D., Spencer, H. C, and Rowe, U. K. The response of rabbit skin to compounds reported to have caused acne form dermatitis, Industrial Medicine, Industrial Hygiene Section 2, 1-4 (1941).
Anonymous, The Sheffield Star, 2 August 1976.
Anonymous, The Sheffield Star, 30 July 1976.
Needham, C. Personal interview, 22 July 1977.
The Times, The Guardian, The Daily Telegraph, 13 August 1976.
Anonymous, The Sheffield Morning Telegraph, 15 October 1976.
Anonymous, The Sheffield Morning Telegraph, 7 August 1976.
Anonymous, The Sheffield Star, 23 October 1976.
Young, A. L., Tahlken, C. E., Arnold, E. L., Cupello, J. M., and Cockerman, L. G. Fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the environment: summary and decontamination recommendations, USAFA-TR-76-18, Department of Chemistry and Biological Sciences, USAF Academy, Colorado 80840 (1976).
Di Domenico, A., Silano, V., Viviano, G., and Zapponi, G. Accidental Release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Seveso (Italy): V. Environmental Persistence (Half Life) of TCDD in Soil, Instituto Superiore di Sanita (26 January 1980).
Caufield, C., and Pearce, F. An overburden of toxic waste, New Scientist 90, 344–347 (1981).
Needham, C. Television interview, 7 May 1981.
Anonymous, The Sheffield Star, 11 August 1976.
Anonymous, The Sheffield Morning Telegraph, 8 October 1976.
Anonymous, The Sheffield Star, 23 December 1976.
Anonymous, The Sheffield Star, 31 December 1976.
Anonymous, The Sheffield Morning Telegraph, 10 September 1976.
Marshall, R. P. Personal interview, October 1978.
Ashby, J., Styles, J. A., Elliot, B., and Hay, A. W. M. (unpublished).
Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., Hummel, R. A., and Humiston, C. G. Results of a two year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats, Toxicology and Applied Pharmacology 46, 279–303 (1978).
Blank, C. E. Bolsover Project 1977–1978, Genetic damage (Report to Coalite).
Ward, A. M. Investigation of the immune capability of workers previously exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Report to Coalite).
Martin, J. V. Report of a biochemical study carried out on workers at Coalite and Chemical Products Limited, Chesterfield, Derbyshire (Report to Coalite).
Walker, A. E., and Martin, J. V. Lipid profiles in dioxin-exposed workers, Lancet I, 446 (1979).
Hay, A. Chemical company suppresses dioxin report, Nature (London) 284, 2 (1980).
Anonymous. A study of workers who have been, or were liable to have been exposed to dioxin, carried out, on behalf of Coalite and Chemical Products Limited, at the plant of the manufacturing subsidiary company, Coalite Oils and Chemicals Limited (November, 1978).
Ratcliffe, R. Sunday Times, 9 March 1980.
Ratcliffe, R. Sunday Times, 16 March 1980.
Anonymous, Yorkshire Post, 20 March 1980.
Hay, A. Coalite health survey talks, Nature (London) 285, 4 (1980).
New release, Health and Safety Executive (1 May 1980).
Hay, A. Dioxin hazards: secrecy at Coalite, Nature (London), 290, 729 (1981).
Bain, S. The Sheffield Star (27 June 1980).
Report on Coalite Chemicals, Health and Safety Office, ASTMS (May 1980).
Soviet Union
Telegina, K. A., and Bikbulatova, L. I. Effects on the follicular apparatus of the skin of workers occupied in the production of the butyl ester of 2,4,5-trichlorophenoxyacetic acid (English translation), Vestnik Dermatologii i Venerologii 44, 35–39 (March 1970).
Crow, K. D. Chloracne: the chemical disease, New Scientist, 78-80 (13 April 1978).
Missouri
Kimbrough, R. D., Carter, C. D., Liddle, J. A., Cline, R. E., and Philips, P. E. Epidemiology and pathology of a tetrachlorodibenzodioxin poisoning episode, Archives of Environmental Health 32, 77–86 (1977).
Commoner, B., and Scott, R. E. Accidental contamination of soil with dioxin at Missouri: effects and countermeasures, a contribution to the Dioxin Information Project, Scientists’ Institute for Public Information, New York (29 September 1976).
Donnel, H. D., and Philips, P. E. Draft report to the Director of the Missouri State Division of Health from the section of epidemiology (11 September 1974).
Beale, M. A., Shearer, W. T., Karl, M. M., and Robson, A. M. Long term effects of dioxin exposure, Lancet I, 748 (1977).
Lobes, L. A., Koehler, R. F., et al. Administrative report to the Director of the Center for Disease Control (CDC) on Toxic illness, Lincoln County, Missouri, CDC Number EPI-72-13-2, U.S. Public Health Service, CDC, Atlanta, Georgia (14 August 1972).
Report to Director, Centers for Disease Control, from Cancer and Birth Defects Division, Bureau of Epidemiology, and Clinical Chemistry Division, Bureau of Laboratories, HEW, Public Health Service—CDC—Atlanta, EPI-75-17-2 (31 March 1975).
Letter to Senator Philip A. Hart, Chairman, Sub-committee on the Environment, Committee on Commerce, United States Senate from David J. Spencer, MD, Assistant Surgeon General, Director, Department of Health, Education and Welfare (15 September 1974).
Memorandum to Chief, Bacterial Diseases Branch from Renate D. Kimbrough, HEW, Public Health Service, Centers for Disease Control, Atlanta, Georgia (30 July 1974).
Letter to Mr. Paul E. des Rosiers, Staff Engineer, Office of Energy, Minerals and Industry Environmental Protection Agency, from Renate D. Kimbrough (12 June 1975).
Kimbrough, R. D. Personal letter (11 September 1979).
EPA official, personal interview (3 March 1980).
des Rosiers, P. E. Personal interview (11 May 1980).
Diamond Alkali
Poland, A. M., Smith, D., Mether, G., and Possick, P. A health survey of workers in a 2,4-D and 2,4,5-T plant, Archives of Environmental Health 22, 316–327 (1971).
Bleiberg, J., Wallen, M., Brodkin, R., and Appelbaum, L. Industrially acquired porphyria, Archives of Dermatology 89, 793–797 (1964).
Spolana
Jirasek, L., Kalensky, J., and Kubeck, K. Acne chlorine and porphyria cutanea tarda during manufacture of herbicides, Ceskoslovenska Dermatologie 48, 306–317 (1973).
Jirasek, L., Kalensky, J., Kubeck, K., Pazderova, J., and Lukas, E. Acne chlorine, porphyria cutanea tarda and other manifestations of general intoxication during the manufacture of herbicides, Ceskoslovenska Dermatologie 49, 145–147 (1974).
Jirasek, L. Presentation to Joint National Institute of Environmental Health Sciences/ International Agency for Research on Cancer working group, on Long Term Hazards of Chlorinated Dibenzodioxins/Chlorinated Dibenzofurans, International Agency for Research on Cancer, Lyons (10–11 January 1978).
Pazderova-Vejlupkova, J., Nemcova, M., Pickova, J., Jirasek, L., and Lukas, E. The development and progress of chronic intoxication by tetrachlorodibenzo-p-dioxin in men, Archives of Environmental Health 36, 5–11 (1981).
Spontaneous and induced abortion, Report of a WHO Scientific Group, World Health Organization Technical Report Series, No. 461, Geneva (1970).
Boehringer
Kraus, Von L., and Brassau, H. Katamnestischer Beitrag zu sog Chlorakneer Krankungen aus dem Jahre 1954/55, Arbeitsmedizin Socialmedizin Praventivmedizin 13, 19–21 (1978).
Rhone-Poulenc
Dugois, P., Marechal, J., and Colomb, L. Chloracne caused by 2,4,5-trichlorophenol, Archives des Maladies Professionelles Hygiene et Toxicologie Industrielles 19, 626–627 (1958).
Dugois, P., and Colomb, L. Acne chlorique au 2,4,5-trichlorophenol, Lyon Medical 88, 446–447 (1956).
Dugois, P., and Colomb, L. Remarques sur l’acne chlorique (a propos d’une eclosion de cas provoques par la preparations du 2,4,5-trichlorophenol), Le Journal de Medicine de Lyon 38, 899–903 (1957).
Dow Chemical
Ott, M. G., Holder, B. B., and Olson, R. D. A mortality analysis of employees engaged in the manufacture of 2,4,5-trichlorophenoxyacetic acid, Journal of Occupational Medicine 22, 47–50 (1980).
Cookson, C. Emergency ban on 2,4,5-T herbicide in U.S., Nature (London) 278, 108–109 (1979).
Hay, A. Critics challenge data that led to 2,4,5-T ban, Nature (London) 279, 3 (1979).
Editorial: Dioxin and 2,4,5-T: What are the Risks? Nature (London) 284, 111 (1980).
Patton, D. E., Lee, K. M., Roberts, P. A. Bozof, R. P., Backstram, T. D., and Morrison, S. E. Respondents’ prehearing brief on the risks associated with the registered uses of 2,4,5-T and Silvex, U.S. Environmental Protection Agency before the Administrator FIFRA Docket Nos. 415 et al.
Dioxin traces found in soldiers exposed to defoliant, Nature (London) 282, 772 (1979).
Defoliant companies can be sued, Nature (London) 282, 434 (1979).
Kavanagh, K. Office of Victor Yannacome, personal communication to the author (2 June 1980).
Cook, R. R., Townsend, J. C., Ott, M. G., and Silverstein, L. G. Mortality experience of employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), Journal of Occupational Medicine 22, 530–532 (1980).
Honchar, P. A., and Halperin, W. E. 2,4,5-T, trichlorophenol and soft tissue sarcomas, Lancet I, 268–269 (1981).
Cook, R. R. Dioxin, chloracne and soft tissue sarcoma. Lancet I, 618–619 (1981).
Rowe, V. K. Direct Testimony of Dr. V. K. Rowe (Exhibit 865) before the Environmental Protection Agency of the United States of America. 13 November 1980.
Transcript of U.S. Environmental Protection Agency Hearings in Re: The Dow Chemical Company et al. p. 17087. November 1980.
Monsanto—Newport
Monsanto stops PCP plant at Newport, European Chemical News, 1 September 1978, p. 7.
Notes of an informal meeting to discuss chloracne, Health and Safety Executive, 7 November 1979.
Dr. Alex Munn, personal communication, January 1980.
Workers given EMAS assessment of survey of dioxin exposure at Coalite plant, Health and Safety Executive press release (1 May 1980).
Ministry of Agriculture, U.K.
Oliver, R. M. Toxic effects of 2,3,7,8-tetrachlorodibenzo 1,4-dioxin in laboratory workers, British Journal of Industrial Medicine 32, 49–53 (1975).
Jacobs, P. The Times, 13 October 1976.
Hooker, Thompson Hayward, Bayer, and Chemie-Linz
Hay, A. W. M. Tetrachlorodibenzo-p-dioxin release at Seveso, Disasters 1, 289–308 (1977).
Halperin, W. Personal letter, 23 July 1979.
Halperin, W. Personal letter, 14 September 1979.
Hay, A. Chemical company suppresses dioxin report, Nature (London), 284, 2 (1980).
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Hay, A. (1982). Industrial Accidents in Trichlorophenol Manufacture. In: The Chemical Scythe. Disaster Research in Practice. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0339-6_7
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