Pollution pp 708-729 | Cite as

Teratological Hazards due to Phenoxy Herbicides and Dioxin Contaminants

  • Samuel S. Epstein
Part of the Environmental Science Research book series (ESRH, volume 2)


Potential hazards posed by environmental pollutants and drugs include toxicity per se, carcinogenicity, mutagenicity, and teratogenicity. Although teratogenic effects of various agents have been recognized for several decades, it was only as a reaction to the thalidomide episode that a requirement for teratogenicity data became established in 1962.


Advisory Committee Teratogenic Effect Abnormal Fetus Cystic Kidney Porphyria Cutanea Tarda 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adang, P.J. Personal Communication 11/19/71Google Scholar
  2. Agricultural Economic Report No. 131 Economic Research Service, U.S.D.A., Washington, D.C. 1968 Quantities of Pesticides used by Farmers in 1964Google Scholar
  3. Allen, J.R. Am. J. Vet. Res: 28, 1513, 1967Google Scholar
  4. Bamesberger, W.L., and Adams, D.R. In, Organic Pesticides in the Environment Advan. Chem. Ser: 60, 1966Google Scholar
  5. Bionetics Research Laboratories Unpublished Report, 1969Google Scholar
  6. Bleiberg, J., Wallen, M., Brodkin, R., and Applebaum, I. Arch. Derm. 89, 793, 1964CrossRefGoogle Scholar
  7. Buu-Hoi, N.P., Saint-Ruf, G., Bigot, P., and Mangane, M. C.R. Acad. Sci. Series D: 273, 708, 1971Google Scholar
  8. Buu-Hoi, N.P. Personal Communication, 1972Google Scholar
  9. Constable, J., and Meselson, M. Sierra Club Bulletin: 56, 4, 1971Google Scholar
  10. Courtney, D.K., and Moore, J.A. Toxicol. Appl. Pharmacol: 201, 396, 1971CrossRefGoogle Scholar
  11. Cowan, J.C. U.S.D.A. Memo, Possible sources of polychlorodibenzodioxins in fats. 2/12/70Google Scholar
  12. Darving, L., and Sunner, M. Hereditas: 68, 115, 1971Google Scholar
  13. Dawson, J.E. Diabetes, 13, 527, 1964Google Scholar
  14. Dow Chemical Co Report to PSAC, 1971Google Scholar
  15. Drill, V.A., and Hiratzka, T. Ind. Hygiene and Occupat. Med: 1, 61, 1953Google Scholar
  16. Emerson, J.L., Thompson, D.J., Strebing, R.J., Gerbig, C.G., and Robinson, V.B. Fd. Cosmet. Toxicol. 9, 395, 1971CrossRefGoogle Scholar
  17. Epstein, S.S. Nature: 228, 816, 1970ADSCrossRefGoogle Scholar
  18. Erne, K., and Nordkvist, M.-Nat. Swedish Vet. Inst. Communication 308/70/KA, 5/20/70Google Scholar
  19. FDA Unpublished data, 1970 Federal Register, 5/21/69Google Scholar
  20. Inensee, A.R., and Jones, G.E. J. Agric. Fd. Chem. in Press, 1972Google Scholar
  21. Kalter, H. Teratology of the Central Nervous System University of Chicago Press, 1960Google Scholar
  22. Kearney, P.C., Isensee, A., Helling, C.S., Woolson, E.A., and Plimmer, J.R. Abstr. 161st National Meeting Am. Chem. Soc. March, 1971Google Scholar
  23. Kettering Laboratory Unpublished Reports, Communication to PSAC, 1971Google Scholar
  24. Kimmig, J., and Schulz, K.D. Dermatologica, 115, 540, 1957CrossRefGoogle Scholar
  25. King, C. J. Pharm. Exp. Therap. 147, 391, 1965Google Scholar
  26. Lichtenstein, H., Guest, G.M., and Warkany, J. Proc. Soc. Exp. Biol. and Med: 78, 398, 1951CrossRefGoogle Scholar
  27. Lutz-Ostertag, Y., and Lutz, M.H. C.R. Acad. Sci: 271: Series D, 24, 18, 1970Google Scholar
  28. Meselson, M.S., Westing, A.H., Constable, J.D., and Cook, R.E. Preliminary Report of the Herbicide Assessment Commission of The American Association for the Advancement of Science Hearings by Senator E. Kennedy, Chairman, Sub-Committee to Investigate Problems Connected with Refugees and Escapees, of the U.S. Senate Committee on the Judiciary, 92nd Congress, 4/21/71Google Scholar
  29. Oberle, M.W. Science: 165, 991, 1969ADSCrossRefGoogle Scholar
  30. Poland, A.P., Smith, D., Metter, G., and Possick, P. AMA Archives Environ. Health: 22, 316, 1971Google Scholar
  31. President’s Science Advisory Committee (PSAC) Report of the Panel on Herbicides: Report on 2,4, 5-T Office of Science and Technology, Washington, D.C., 3/71Google Scholar
  32. Report on the Secretary’s Commission on Pesticides and Their Relationship to Environmental Health: Advisory Panel on Teratogenicity of Pesticides, HEW, December, 1969Google Scholar
  33. Silverstein, L.C., Dow Chemical Co. Memo. Safe Handling of Tetrachlorodibenzo-p-dioxin (TCBD) in the Laboratory: 2/7/70Google Scholar
  34. Sparschu, G.L., Dunn, F.L., and Rowe, V.K. Fd. Cosmet. Toxicol: 9, 405, 1971CrossRefGoogle Scholar
  35. Tarrant, R.F., and Norris, L.A. Proc. Symposium on Herbicides in Vegetation Management Oregon State University, 1967Google Scholar
  36. Verrett, J. Testimony Before the Subcommittee of Energy, Natural Resources and the Environment of the U.S. Senate Committee on Commerce, 91st Congress, 4/15/70Google Scholar
  37. Yerushalamy, J., and Milkovich, L. Am. J. Obs. Gynae: 93, 553, 1965Google Scholar
  38. Westing, A.H. Bioscience: 21, 893, 1971CrossRefGoogle Scholar
  39. Wooton, J.C. Chem. and Eng. News: 45, 10, 1967Google Scholar

Copyright information

© Springer Science+Business Media New York 1973

Authors and Affiliations

  • Samuel S. Epstein
    • 1
  1. 1.Case Western Reserve University School of MedicineClevelandUSA

Personalised recommendations