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Immunopathogenesis of Entamoeba histolytica

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Enteric Infections and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

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Abstract

Entamoeba histolytica is an enteric protozoan parasite that infects up to 10% of the world’s population resulting in 100,000 deaths per year from amebic colitis and liver abscess.(1) The parasite’s distribution is worldwide. Humans are infected by two morphologically identical species of amoebae: Entamoeba histolytica Schaudinn, 1903, which is pathogenic and is capable of causing invasive amebiasis (but remains as a harmless commensal in the majority of infections), and Entamoeba dispar Brumpt, 1925, which is not pathogenic. Biochemical, immunological, genetic, and clinical characteristics support the existence of the two different and well-defined species.(2) This important finding has clarified the long-standing issue of interconverting amoebae and has explained the low percentage of individuals with clinical symptoms.

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Authors and Affiliations

  1. Institute of Parasitology, McGill University, Ste-Anne de Bellevue, Quebec, H9X 3V9, Canada

    Sergio Arias-Negrete & Kris Chadee

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  1. Sergio Arias-Negrete
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  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Lois J. Paradise  & Herman Friedman  & 

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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Arias-Negrete, S., Chadee, K. (1996). Immunopathogenesis of Entamoeba histolytica . In: Paradise, L.J., Bendinelli, M., Friedman, H. (eds) Enteric Infections and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0313-6_11

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