Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor

  • N. Jan Chalupny
  • Liqing Zhu
  • Xue-zhong Yu
  • Claudio Anasetti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)


The term apoptosis refers to the morphological process of programmed cell death, a physiological event that occurs at specific stages of normal embryonic development as well as in adult life.1 During programmed cell death, cells undergo profound structural changes. The plasma membrane becomes ruffled or ‘blebbed’. The nucleus shrinks, but the morphology of other cytoplasmic organelles remains relatively unchanged. Within the nucleus, the chromatin condenses, and tends to collapse into patches around the nuclear envelope. Condensation of the chromatin is often accompanied by fragmentation of the DNA, caused by internucleosomal cleavage, resulting in the characteristic ‘ladder’ pattern of bands seen upon electrophoretic separation. The cell may finally break up into apoptotic bodies, which are rapidly phagocytosed.2–4


Programme Cell Death Induce Cell Death Jurkat Cell Thymidine Uptake Mutant Cell Line 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • N. Jan Chalupny
    • 1
  • Liqing Zhu
    • 1
  • Xue-zhong Yu
    • 1
  • Claudio Anasetti
    • 1
  1. 1.Human Immunogenetics Program Division of Clinical ResearchFred Hutchinson Cancer Research CenterSeattleUSA

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