The Thymus and T Cell Death

  • Jonathan Sprent
  • Hidehiro Kishimoto
  • Zeling Cai
  • Charles D. Surh
  • Anders Brunmark
  • Michael R. Jackson
  • Per A. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)


Through the combined effects of positive and negative selection, T cell differentiation in the thymus generates a repertoire of mature T cells that is tailored to tolerate self antigens but mount strong responses to foreign antigens1,2. Thymic selection is associated with extensive cell death, and only a very small proportion of thymocytes are selected for survival and export to the extrathymic environment. This article provides an overview of thymic selection and the fate of thymocytes.


Major Histocompatibility Complex Negative Selection TUNEL Staining Major Histocompatibility Complex Molecule Major Histocompatibility Complex Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Jonathan Sprent
    • 1
  • Hidehiro Kishimoto
    • 1
  • Zeling Cai
    • 1
  • Charles D. Surh
    • 1
  • Anders Brunmark
    • 2
  • Michael R. Jackson
    • 2
  • Per A. Peterson
    • 2
  1. 1.Department of Immunology, IMM4The Scripps Research InstituteLa JollaUSA
  2. 2.R.W. Johnson Pharmaceutical ResearchSan DiegoUSA

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